Lipodistrofias primarias: presentación clínica y diagnóstico

Lipodystrophies are a heterogeneous group of syndromes defined by a severe reduction of the adipose tissue. These can be congenital or acquired. Anatomically, they can be partial or generalized. The etiology of several lipodystrophies is well known. However, the cause of many others remains unknown....

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	CORTÉS,VÍCTOR, SANTOS,JOSÉ LUIS
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Adipose Tissue Diabetes Melllitus Insulin Resistance Leptin Lipodystrophy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101449
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872019001101449
record_format	dspace
spelling	oai:scielo:S0034-988720190011014492020-02-25Lipodistrofias primarias: presentación clínica y diagnósticoCORTÉS,VÍCTORSANTOS,JOSÉ LUIS Adipose Tissue Diabetes Melllitus Insulin Resistance Leptin Lipodystrophy Lipodystrophies are a heterogeneous group of syndromes defined by a severe reduction of the adipose tissue. These can be congenital or acquired. Anatomically, they can be partial or generalized. The etiology of several lipodystrophies is well known. However, the cause of many others remains unknown. The commonest lipodystrophy worldwide is secondary to highly active anti-retroviral therapy in HIV-infected patients. By contrast, primary lipodystrophies (those not associated to any known disease or condition) are much less common and represent a diagnostic challenge. The major complications of lipodystrophies are metabolic, often resulting in severe insulin resistance, diabetes and dyslipidemia. No cure is available for lipodystrophies but the supplementation with recombinant leptin potently controls the metabolic abnormalities when there is a leptin deficiency. Herein, we review the clinical presentation, diagnostic process and therapeutic principles of the main primary lipodystrophy syndromes.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.11 20192019-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101449es10.4067/S0034-98872019001101449
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Adipose Tissue Diabetes Melllitus Insulin Resistance Leptin Lipodystrophy
spellingShingle	Adipose Tissue Diabetes Melllitus Insulin Resistance Leptin Lipodystrophy CORTÉS,VÍCTOR SANTOS,JOSÉ LUIS Lipodistrofias primarias: presentación clínica y diagnóstico
description	Lipodystrophies are a heterogeneous group of syndromes defined by a severe reduction of the adipose tissue. These can be congenital or acquired. Anatomically, they can be partial or generalized. The etiology of several lipodystrophies is well known. However, the cause of many others remains unknown. The commonest lipodystrophy worldwide is secondary to highly active anti-retroviral therapy in HIV-infected patients. By contrast, primary lipodystrophies (those not associated to any known disease or condition) are much less common and represent a diagnostic challenge. The major complications of lipodystrophies are metabolic, often resulting in severe insulin resistance, diabetes and dyslipidemia. No cure is available for lipodystrophies but the supplementation with recombinant leptin potently controls the metabolic abnormalities when there is a leptin deficiency. Herein, we review the clinical presentation, diagnostic process and therapeutic principles of the main primary lipodystrophy syndromes.
author	CORTÉS,VÍCTOR SANTOS,JOSÉ LUIS
author_facet	CORTÉS,VÍCTOR SANTOS,JOSÉ LUIS
author_sort	CORTÉS,VÍCTOR
title	Lipodistrofias primarias: presentación clínica y diagnóstico
title_short	Lipodistrofias primarias: presentación clínica y diagnóstico
title_full	Lipodistrofias primarias: presentación clínica y diagnóstico
title_fullStr	Lipodistrofias primarias: presentación clínica y diagnóstico
title_full_unstemmed	Lipodistrofias primarias: presentación clínica y diagnóstico
title_sort	lipodistrofias primarias: presentación clínica y diagnóstico
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101449
work_keys_str_mv	AT cortesvictor lipodistrofiasprimariaspresentacionclinicaydiagnostico AT santosjoseluis lipodistrofiasprimariaspresentacionclinicaydiagnostico
_version_	1718437092871110656

Lipodistrofias primarias: presentación clínica y diagnóstico

Ejemplares similares