Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico

^aThe 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The...

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Autores principales:	ARANEDA,PATRICIA, SUJIMA,EMI, PAREDES-MANZO,PATRICIO, VALLEJO,RODRIGO, VALDIVIA,FELIPE, SINNING,MARIANA, GALLEGOS,MARCELA, FULLER,GREGORY
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Astrocytoma Glioma Histones
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101487
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spelling	oai:scielo:S0034-988720190011014872020-02-25Glioma difuso de línea media H3K27M positivo en adulto. Caso clínicoARANEDA,PATRICIASUJIMA,EMIPAREDES-MANZO,PATRICIOVALLEJO,RODRIGOVALDIVIA,FELIPESINNING,MARIANAGALLEGOS,MARCELAFULLER,GREGORY Astrocytoma Glioma Histones ^aThe 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The imaging study showed a mesencephalic tumor; the stereotacic biopsy disclosed an Anaplastic Astrocytoma Isocitrate dehydrogenase (IDH) wild type. The molecular study concludes H3K27 mutation. The patient was treated with radiotherapy with concurrent and adjuvant chemotherapy (temozolomide) with partial recovery of the diplopia.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.11 20192019-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101487es10.4067/S0034-98872019001101487
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Astrocytoma Glioma Histones
spellingShingle	Astrocytoma Glioma Histones ARANEDA,PATRICIA SUJIMA,EMI PAREDES-MANZO,PATRICIO VALLEJO,RODRIGO VALDIVIA,FELIPE SINNING,MARIANA GALLEGOS,MARCELA FULLER,GREGORY Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico
description	^aThe 2016 WHO Classification of Tumours of the Central Nervous System incorporates a new diagnostic entity: the mutant diffuse midline glioma H3K27, a tumor with a characteristic location and special molecular biology. We report the case of a 51-year-old male patient with progressive diplopia. The imaging study showed a mesencephalic tumor; the stereotacic biopsy disclosed an Anaplastic Astrocytoma Isocitrate dehydrogenase (IDH) wild type. The molecular study concludes H3K27 mutation. The patient was treated with radiotherapy with concurrent and adjuvant chemotherapy (temozolomide) with partial recovery of the diplopia.
author	ARANEDA,PATRICIA SUJIMA,EMI PAREDES-MANZO,PATRICIO VALLEJO,RODRIGO VALDIVIA,FELIPE SINNING,MARIANA GALLEGOS,MARCELA FULLER,GREGORY
author_facet	ARANEDA,PATRICIA SUJIMA,EMI PAREDES-MANZO,PATRICIO VALLEJO,RODRIGO VALDIVIA,FELIPE SINNING,MARIANA GALLEGOS,MARCELA FULLER,GREGORY
author_sort	ARANEDA,PATRICIA
title	Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico
title_short	Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico
title_full	Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico
title_fullStr	Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico
title_full_unstemmed	Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico
title_sort	glioma difuso de línea media h3k27m positivo en adulto. caso clínico
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001101487
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Glioma difuso de línea media H3K27M positivo en adulto. Caso clínico

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