Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma

ABSTRACT Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International Prognostic Index or the Revised Internatio...

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Autores principales:	IRIGOÍN,VICTORIA, OLIVER,CAROLINA, LÓPEZ,STEFANÍA, LANDONI,ANA INÉS, GABÚS,RAÚL, DÍAZ,LILIÁN
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Lymphoma, Large B-Cell, Diffuse Monocytes Prognosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001201553
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spelling	oai:scielo:S0034-988720190012015532020-07-22Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphomaIRIGOÍN,VICTORIAOLIVER,CAROLINALÓPEZ,STEFANÍALANDONI,ANA INÉSGABÚS,RAÚLDÍAZ,LILIÁN Lymphoma, Large B-Cell, Diffuse Monocytes Prognosis ABSTRACT Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International Prognostic Index or the Revised International Prognostic Index (R_IPI) incorporate patient and tumor characteristics but do not consider variables related to host adaptive immunity which have been shown to be of significant prognostic value in non-Hodgkin lymphomas. Aim To analyze the prognostic significance of the absolute monocyte count at diagnosis in diffuse large-B-cell lymphoma in a retrospective setting. Material and Methods We reviewed data of 171 patients with DLBCL treated with Rituximab-based immunochemotherapy at two reference public Hospitals in Montevideo-Uruguay. The outcome measures were overall and relapse free survival. Results The absolute monocyte count, analyzed as a dichotomized variable predicted progression-free and overall survival in low risk patients according to the R-IPI score. Worse outcomes were observed in those with high monocyte count al diagnosis. Conclusions Absolute monocyte count could help in the identification of high-risk patients otherwise expected to have a good prognosis according to traditional scores.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.12 20192019-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001201553en10.4067/S0034-98872019001201553
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Lymphoma, Large B-Cell, Diffuse Monocytes Prognosis
spellingShingle	Lymphoma, Large B-Cell, Diffuse Monocytes Prognosis IRIGOÍN,VICTORIA OLIVER,CAROLINA LÓPEZ,STEFANÍA LANDONI,ANA INÉS GABÚS,RAÚL DÍAZ,LILIÁN Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma
description	ABSTRACT Background Prognosis of patients with Diffuse Large B Cell Lymphoma (DLBCL) is highly variable, and despite the use of modern immunochemotherapy regimens, almost 50% of patients will eventually relapse. Standard risk models, like the International Prognostic Index or the Revised International Prognostic Index (R_IPI) incorporate patient and tumor characteristics but do not consider variables related to host adaptive immunity which have been shown to be of significant prognostic value in non-Hodgkin lymphomas. Aim To analyze the prognostic significance of the absolute monocyte count at diagnosis in diffuse large-B-cell lymphoma in a retrospective setting. Material and Methods We reviewed data of 171 patients with DLBCL treated with Rituximab-based immunochemotherapy at two reference public Hospitals in Montevideo-Uruguay. The outcome measures were overall and relapse free survival. Results The absolute monocyte count, analyzed as a dichotomized variable predicted progression-free and overall survival in low risk patients according to the R-IPI score. Worse outcomes were observed in those with high monocyte count al diagnosis. Conclusions Absolute monocyte count could help in the identification of high-risk patients otherwise expected to have a good prognosis according to traditional scores.
author	IRIGOÍN,VICTORIA OLIVER,CAROLINA LÓPEZ,STEFANÍA LANDONI,ANA INÉS GABÚS,RAÚL DÍAZ,LILIÁN
author_facet	IRIGOÍN,VICTORIA OLIVER,CAROLINA LÓPEZ,STEFANÍA LANDONI,ANA INÉS GABÚS,RAÚL DÍAZ,LILIÁN
author_sort	IRIGOÍN,VICTORIA
title	Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma
title_short	Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma
title_full	Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma
title_fullStr	Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma
title_full_unstemmed	Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma
title_sort	absolute monocyte count as a prognostic parameter in diffuse large b cell lymphoma
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001201553
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Absolute monocyte count as a prognostic parameter in diffuse large B cell lymphoma

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