Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico

Toxic alcohols can produce severe poisoning with multiple organic involvement and even death. The most common form is ethylene glycol. The diagnosis can be extremely difficult if there is no history of its consumption. Its clinical presentation can simulate other conditions. Ethylene glycol poisonin...

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Autores principales:	A. SEPÚLVEDA,RODRIGO, SELAMÉ,ESPERANZA, ROESSLER,ERIC, TAGLE,RODRIGO, VALDIVIESO,ANDRÉS
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2019
Materias:	Alcohols Ethylene Glycol Poisoning Therapeutics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001201572
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spelling	oai:scielo:S0034-988720190012015722020-07-22Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínicoA. SEPÚLVEDA,RODRIGOSELAMÉ,ESPERANZAROESSLER,ERICTAGLE,RODRIGOVALDIVIESO,ANDRÉS Alcohols Ethylene Glycol Poisoning Therapeutics Toxic alcohols can produce severe poisoning with multiple organic involvement and even death. The most common form is ethylene glycol. The diagnosis can be extremely difficult if there is no history of its consumption. Its clinical presentation can simulate other conditions. Ethylene glycol poisoning is characterized by an initial rise in plasma osmolal gap that decreases during the evolution, while alcohol is metabolized to acids. This last condition causes a metabolic acidosis with elevated anion gap. The clinical manifestations are diffuse neurological involvement initially, followed by hemodynamic alterations due to myocardial damage associated with hypocalcemia and acidemia. Subsequently, severe tubular renal damage appears, which may require renal replacement therapy, and finally, focal neurological alterations. To treat this poisoning, it is necessary to inhibit the transformation of alcohol into acids, increase the metabolism of the latter or withdraw them directly with hemodialysis.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.147 n.12 20192019-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001201572en10.4067/S0034-98872019001201572
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Alcohols Ethylene Glycol Poisoning Therapeutics
spellingShingle	Alcohols Ethylene Glycol Poisoning Therapeutics A. SEPÚLVEDA,RODRIGO SELAMÉ,ESPERANZA ROESSLER,ERIC TAGLE,RODRIGO VALDIVIESO,ANDRÉS Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico
description	Toxic alcohols can produce severe poisoning with multiple organic involvement and even death. The most common form is ethylene glycol. The diagnosis can be extremely difficult if there is no history of its consumption. Its clinical presentation can simulate other conditions. Ethylene glycol poisoning is characterized by an initial rise in plasma osmolal gap that decreases during the evolution, while alcohol is metabolized to acids. This last condition causes a metabolic acidosis with elevated anion gap. The clinical manifestations are diffuse neurological involvement initially, followed by hemodynamic alterations due to myocardial damage associated with hypocalcemia and acidemia. Subsequently, severe tubular renal damage appears, which may require renal replacement therapy, and finally, focal neurological alterations. To treat this poisoning, it is necessary to inhibit the transformation of alcohol into acids, increase the metabolism of the latter or withdraw them directly with hemodialysis.
author	A. SEPÚLVEDA,RODRIGO SELAMÉ,ESPERANZA ROESSLER,ERIC TAGLE,RODRIGO VALDIVIESO,ANDRÉS
author_facet	A. SEPÚLVEDA,RODRIGO SELAMÉ,ESPERANZA ROESSLER,ERIC TAGLE,RODRIGO VALDIVIESO,ANDRÉS
author_sort	A. SEPÚLVEDA,RODRIGO
title	Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico
title_short	Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico
title_full	Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico
title_fullStr	Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico
title_full_unstemmed	Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico
title_sort	intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico
publisher	Sociedad Médica de Santiago
publishDate	2019
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872019001201572
work_keys_str_mv	AT asepulvedarodrigo intoxicacionporetilenglicolfisiopatologiayenfrentamientoclinico AT selameesperanza intoxicacionporetilenglicolfisiopatologiayenfrentamientoclinico AT roesslereric intoxicacionporetilenglicolfisiopatologiayenfrentamientoclinico AT taglerodrigo intoxicacionporetilenglicolfisiopatologiayenfrentamientoclinico AT valdiviesoandres intoxicacionporetilenglicolfisiopatologiayenfrentamientoclinico
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Intoxicación por etilenglicol, fisiopatología y enfrentamiento clínico

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