Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayores

Background: Supplementation of vitamin B12 in older adults is a common practice to avoid vitamin B12 insufficiency. However, there is a paucity of information about the effects of cobalamin excess. Aim: To asses any potential effects of high levels vitamin B12 on mortality on adults aged &#880...

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Autores principales:	Valdivia,Gabriel, Navarrete,Camila, Oñate,Aileen, Schmidt,Bettina, Fuentes,Ricardo, Espejo,Eric, Enos,Daniel, Fernandez-Bussy,Isabel, Labarca,Gonzalo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Frail Elderly Inpatients Hospital Medicine Mortality Vitamin B 12
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000100046
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spelling	oai:scielo:S0034-988720200001000462020-04-02Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayoresValdivia,GabrielNavarrete,CamilaOñate,AileenSchmidt,BettinaFuentes,RicardoEspejo,EricEnos,DanielFernandez-Bussy,IsabelLabarca,Gonzalo Frail Elderly Inpatients Hospital Medicine Mortality Vitamin B 12 Background: Supplementation of vitamin B12 in older adults is a common practice to avoid vitamin B12 insufficiency. However, there is a paucity of information about the effects of cobalamin excess. Aim: To asses any potential effects of high levels vitamin B12 on mortality on adults aged ≥ 65 years admitted to an internal medicine service. Material and Methods: We Prospectively studied patients admitted to an internal medicine service of an academic hospital from September 2017 to September 2018, who were able to give their consent and answer questionnaires. We tabulated age, gender, medical history, comorbidity index (Charlson), frailty score (Fried scale), admission diagnosis and blood tests performed within 48 hours of admission. The primary outcome was death by any cause in less of 30 days or after one of year follow up, determined according to death certificates. Results: We included 93 patients aged 65 to 94 years (53% males). Fifteen patients died during the year of follow up (five within 30 days of admission). Those who died had higher cobalamin levels than survivors (1080.07 ± 788.09 and 656.68 ± 497.33 pg/mL respectively, p = 0.02). Patients who died had also a significantly lower corrected serum calcium, sodium (p = 0.04) and a medical history of chronic liver disease (p = 0.03). In the multivariable analysis, only vitamin B12 preserved the association with mortality (p = 0.009). Conclusions: There was a significant association between high levels of cobalamin and all-cause mortality in this group of patients aged ≥ 65 years-old.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.1 20202020-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000100046es10.4067/S0034-98872020000100046
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Frail Elderly Inpatients Hospital Medicine Mortality Vitamin B 12
spellingShingle	Frail Elderly Inpatients Hospital Medicine Mortality Vitamin B 12 Valdivia,Gabriel Navarrete,Camila Oñate,Aileen Schmidt,Bettina Fuentes,Ricardo Espejo,Eric Enos,Daniel Fernandez-Bussy,Isabel Labarca,Gonzalo Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayores
description	Background: Supplementation of vitamin B12 in older adults is a common practice to avoid vitamin B12 insufficiency. However, there is a paucity of information about the effects of cobalamin excess. Aim: To asses any potential effects of high levels vitamin B12 on mortality on adults aged ≥ 65 years admitted to an internal medicine service. Material and Methods: We Prospectively studied patients admitted to an internal medicine service of an academic hospital from September 2017 to September 2018, who were able to give their consent and answer questionnaires. We tabulated age, gender, medical history, comorbidity index (Charlson), frailty score (Fried scale), admission diagnosis and blood tests performed within 48 hours of admission. The primary outcome was death by any cause in less of 30 days or after one of year follow up, determined according to death certificates. Results: We included 93 patients aged 65 to 94 years (53% males). Fifteen patients died during the year of follow up (five within 30 days of admission). Those who died had higher cobalamin levels than survivors (1080.07 ± 788.09 and 656.68 ± 497.33 pg/mL respectively, p = 0.02). Patients who died had also a significantly lower corrected serum calcium, sodium (p = 0.04) and a medical history of chronic liver disease (p = 0.03). In the multivariable analysis, only vitamin B12 preserved the association with mortality (p = 0.009). Conclusions: There was a significant association between high levels of cobalamin and all-cause mortality in this group of patients aged ≥ 65 years-old.
author	Valdivia,Gabriel Navarrete,Camila Oñate,Aileen Schmidt,Bettina Fuentes,Ricardo Espejo,Eric Enos,Daniel Fernandez-Bussy,Isabel Labarca,Gonzalo
author_facet	Valdivia,Gabriel Navarrete,Camila Oñate,Aileen Schmidt,Bettina Fuentes,Ricardo Espejo,Eric Enos,Daniel Fernandez-Bussy,Isabel Labarca,Gonzalo
author_sort	Valdivia,Gabriel
title	Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayores
title_short	Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayores
title_full	Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayores
title_fullStr	Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayores
title_full_unstemmed	Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayores
title_sort	asociación entre niveles de vitamina b-12 y mortalidad en pacientes hospitalizados adultos mayores
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000100046
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Asociación entre niveles de vitamina B-12 y mortalidad en pacientes hospitalizados adultos mayores

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