La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer

The clinical features of Alzheimer's disease (AD), for example the progressive memory loss, are produced by neuronal loss and synaptic dysfunction. These events have been associated with histopathological alterations in AD brain, including the presence of amyloid plaques and neurofibrillary tan...

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Autores principales:	Rivera-Krstulović,Catalina, Duran-Aniotz,Claudia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Alzheimer Disease Endoplasmic Reticulum Stress Unfolded Protein Response
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000200216
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spelling	oai:scielo:S0034-988720200002002162020-06-11La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de AlzheimerRivera-Krstulović,CatalinaDuran-Aniotz,Claudia Alzheimer Disease Endoplasmic Reticulum Stress Unfolded Protein Response The clinical features of Alzheimer's disease (AD), for example the progressive memory loss, are produced by neuronal loss and synaptic dysfunction. These events have been associated with histopathological alterations in AD brain, including the presence of amyloid plaques and neurofibrillary tangles. Recent studies suggest that cellular stress produced by the aggregation of misfolded proteins leads to alterations in protein homeostasis, that is regulated for the most part by endoplasmic reticulum (ER). The ER is the main compartment involved in the folding and secretion of proteins and is drastically affected in AD neurons. Recent evidence implicates the participation of adaptive responses to stress within the ER in the disease process through a signaling pathway known as the Unfolded Protein Response (UPR) which alleviates the protein aggregation and ER stress. Based on the involvement of ER stress in several diseases, efforts are being done to identify small molecules that can inhibit or activate selective UPR components. Here, we review the findings suggesting a functional role of ER stress in the etiology of AD. Possible therapeutic strategies to mitigate ER stress in the context of AD are discussed.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.2 20202020-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000200216es10.4067/s0034-98872020000200216
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Alzheimer Disease Endoplasmic Reticulum Stress Unfolded Protein Response
spellingShingle	Alzheimer Disease Endoplasmic Reticulum Stress Unfolded Protein Response Rivera-Krstulović,Catalina Duran-Aniotz,Claudia La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer
description	The clinical features of Alzheimer's disease (AD), for example the progressive memory loss, are produced by neuronal loss and synaptic dysfunction. These events have been associated with histopathological alterations in AD brain, including the presence of amyloid plaques and neurofibrillary tangles. Recent studies suggest that cellular stress produced by the aggregation of misfolded proteins leads to alterations in protein homeostasis, that is regulated for the most part by endoplasmic reticulum (ER). The ER is the main compartment involved in the folding and secretion of proteins and is drastically affected in AD neurons. Recent evidence implicates the participation of adaptive responses to stress within the ER in the disease process through a signaling pathway known as the Unfolded Protein Response (UPR) which alleviates the protein aggregation and ER stress. Based on the involvement of ER stress in several diseases, efforts are being done to identify small molecules that can inhibit or activate selective UPR components. Here, we review the findings suggesting a functional role of ER stress in the etiology of AD. Possible therapeutic strategies to mitigate ER stress in the context of AD are discussed.
author	Rivera-Krstulović,Catalina Duran-Aniotz,Claudia
author_facet	Rivera-Krstulović,Catalina Duran-Aniotz,Claudia
author_sort	Rivera-Krstulović,Catalina
title	La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer
title_short	La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer
title_full	La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer
title_fullStr	La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer
title_full_unstemmed	La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer
title_sort	la respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de alzheimer
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000200216
work_keys_str_mv	AT riverakrstulovi263catalina larespuestaaproteinasmalplegadascomoblancoterapeuticoenlaenfermedaddealzheimer AT durananiotzclaudia larespuestaaproteinasmalplegadascomoblancoterapeuticoenlaenfermedaddealzheimer
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La respuesta a proteínas mal plegadas como blanco terapéutico en la enfermedad de Alzheimer

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