Poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: Análisis de 19 casos

Background: The presence of multiple lymphadenopathies can be a diagnostic challenge. Aim: To describe the clinical, laboratory and imaging characteristics of 19 patients with lymphadenopathies of rheumatologic origin. Material and Methods: Review of medical records of 19 patients aged 16 to 72 y...

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Autores principales: Erlij,Daniel, Cuellar,María Carolina, Badilla,Natalia, Barros,Perla, Méndez,Ignacio, Rivera,Angela, Foster,Carolina, Wolff,Verónica, Michalland,Susana
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2020
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000300320
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spelling oai:scielo:S0034-988720200003003202020-06-11Poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: Análisis de 19 casosErlij,DanielCuellar,María CarolinaBadilla,NataliaBarros,PerlaMéndez,IgnacioRivera,AngelaFoster,CarolinaWolff,VerónicaMichalland,Susana Lupus Erythematosus, Systemic Lymphadenopathy Rheumatic Diseases Sarcoidosis Sjogren's Syndrome Background: The presence of multiple lymphadenopathies can be a diagnostic challenge. Aim: To describe the clinical, laboratory and imaging characteristics of 19 patients with lymphadenopathies of rheumatologic origin. Material and Methods: Review of medical records of 19 patients aged 16 to 72 years (68%) with lymphadenopathies presumably secondary to a rheumatic disease. Results: Six patients had systemic lupus erythematosus, six had Sjogren's disease, three had sarcoidosis, two had rheumatoid arthritis, one had IgG4 related disease and one had mixed connective tissue disease. A lymph node biopsy was performed in 11 patients and in eight a lymphoid follicular hyperplasia was found. Systemic symptoms were reported by 68% of patients. Blood lactate dehydrogenase was elevated only in cases associated with hemolytic anemia. There was no specific or predictable localization of the lymphadenopathies in imaging studies, except in the cases of sarcoidosis. The average size of the lymphadenopathies was 13.5 mm in diameter in short axis and there was no presence of necrosis, calcification, or conglomerate formation. Only one case presented splenomegaly. All patients responded favorably to corticosteroids. Conclusions: Lymphadenopathies associated with rheumatologic diseases can occur in a wide variety of diseases, especially systemic lupus erythematosus and Sjögren's disease. The absence of LDH elevation and splenomegaly and the absence of imaging findings such as conglomerates can orient to a rheumatologic origin.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.3 20202020-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000300320es10.4067/S0034-98872020000300320
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Lupus Erythematosus, Systemic
Lymphadenopathy
Rheumatic Diseases
Sarcoidosis
Sjogren's Syndrome
spellingShingle Lupus Erythematosus, Systemic
Lymphadenopathy
Rheumatic Diseases
Sarcoidosis
Sjogren's Syndrome
Erlij,Daniel
Cuellar,María Carolina
Badilla,Natalia
Barros,Perla
Méndez,Ignacio
Rivera,Angela
Foster,Carolina
Wolff,Verónica
Michalland,Susana
Poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: Análisis de 19 casos
description Background: The presence of multiple lymphadenopathies can be a diagnostic challenge. Aim: To describe the clinical, laboratory and imaging characteristics of 19 patients with lymphadenopathies of rheumatologic origin. Material and Methods: Review of medical records of 19 patients aged 16 to 72 years (68%) with lymphadenopathies presumably secondary to a rheumatic disease. Results: Six patients had systemic lupus erythematosus, six had Sjogren's disease, three had sarcoidosis, two had rheumatoid arthritis, one had IgG4 related disease and one had mixed connective tissue disease. A lymph node biopsy was performed in 11 patients and in eight a lymphoid follicular hyperplasia was found. Systemic symptoms were reported by 68% of patients. Blood lactate dehydrogenase was elevated only in cases associated with hemolytic anemia. There was no specific or predictable localization of the lymphadenopathies in imaging studies, except in the cases of sarcoidosis. The average size of the lymphadenopathies was 13.5 mm in diameter in short axis and there was no presence of necrosis, calcification, or conglomerate formation. Only one case presented splenomegaly. All patients responded favorably to corticosteroids. Conclusions: Lymphadenopathies associated with rheumatologic diseases can occur in a wide variety of diseases, especially systemic lupus erythematosus and Sjögren's disease. The absence of LDH elevation and splenomegaly and the absence of imaging findings such as conglomerates can orient to a rheumatologic origin.
author Erlij,Daniel
Cuellar,María Carolina
Badilla,Natalia
Barros,Perla
Méndez,Ignacio
Rivera,Angela
Foster,Carolina
Wolff,Verónica
Michalland,Susana
author_facet Erlij,Daniel
Cuellar,María Carolina
Badilla,Natalia
Barros,Perla
Méndez,Ignacio
Rivera,Angela
Foster,Carolina
Wolff,Verónica
Michalland,Susana
author_sort Erlij,Daniel
title Poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: Análisis de 19 casos
title_short Poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: Análisis de 19 casos
title_full Poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: Análisis de 19 casos
title_fullStr Poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: Análisis de 19 casos
title_full_unstemmed Poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: Análisis de 19 casos
title_sort poliadenopatías de origen reumatológico y las claves del diagnóstico diferencial: análisis de 19 casos
publisher Sociedad Médica de Santiago
publishDate 2020
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000300320
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