Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases

ABSTRACT Syphilis during pregnancy has a high risk of congenital transmission with disastrous fetal consequences. Penicillin (PNC) is the only effective antimicrobial for the treatment of pregnant women with syphilis. Chilean guidelines do not consider desensitization to PNC in these women. We repor...

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Autores principales:	Fica,Alberto, Muñoz,Daniel, Rojas,Tamara, Sanzana,Catalina, Muñoz,Camila
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Desensitization, Immunologic Hipersensitivity Penicillins Pregnant Women Syphilis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000300344
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spelling	oai:scielo:S0034-988720200003003442020-06-11Penicillin desensitization in allergic pregnant women with syphilis. Report of two casesFica,AlbertoMuñoz,DanielRojas,TamaraSanzana,CatalinaMuñoz,Camila Desensitization, Immunologic Hipersensitivity Penicillins Pregnant Women Syphilis ABSTRACT Syphilis during pregnancy has a high risk of congenital transmission with disastrous fetal consequences. Penicillin (PNC) is the only effective antimicrobial for the treatment of pregnant women with syphilis. Chilean guidelines do not consider desensitization to PNC in these women. We report two cases of pregnant women aged 32 and 23 years, with immediate allergy to PNC and syphilis who were safely and successfully desensitized using a four-hour intravenous protocol in the critical care unit and who subsequently received benzathine G PNC. An electronic survey was conducted among approximately 100 Clinical Pharmacists (CP) in the country. Of these, 16 answered and 13 reported having experience in drug desensitization, in at least five cases with PNC and none reported deaths or cardiorespiratory arrest. Desensitization to PNC can be carried out safely and in Chile, this alternative should be incorporated to the management of pregnant women with syphilis and immediate allergy to PNC, instead of using erythromycin.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.3 20202020-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000300344en10.4067/S0034-98872020000300344
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Desensitization, Immunologic Hipersensitivity Penicillins Pregnant Women Syphilis
spellingShingle	Desensitization, Immunologic Hipersensitivity Penicillins Pregnant Women Syphilis Fica,Alberto Muñoz,Daniel Rojas,Tamara Sanzana,Catalina Muñoz,Camila Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases
description	ABSTRACT Syphilis during pregnancy has a high risk of congenital transmission with disastrous fetal consequences. Penicillin (PNC) is the only effective antimicrobial for the treatment of pregnant women with syphilis. Chilean guidelines do not consider desensitization to PNC in these women. We report two cases of pregnant women aged 32 and 23 years, with immediate allergy to PNC and syphilis who were safely and successfully desensitized using a four-hour intravenous protocol in the critical care unit and who subsequently received benzathine G PNC. An electronic survey was conducted among approximately 100 Clinical Pharmacists (CP) in the country. Of these, 16 answered and 13 reported having experience in drug desensitization, in at least five cases with PNC and none reported deaths or cardiorespiratory arrest. Desensitization to PNC can be carried out safely and in Chile, this alternative should be incorporated to the management of pregnant women with syphilis and immediate allergy to PNC, instead of using erythromycin.
author	Fica,Alberto Muñoz,Daniel Rojas,Tamara Sanzana,Catalina Muñoz,Camila
author_facet	Fica,Alberto Muñoz,Daniel Rojas,Tamara Sanzana,Catalina Muñoz,Camila
author_sort	Fica,Alberto
title	Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases
title_short	Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases
title_full	Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases
title_fullStr	Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases
title_full_unstemmed	Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases
title_sort	penicillin desensitization in allergic pregnant women with syphilis. report of two cases
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000300344
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Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases

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