Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal

Background The use of narrow therapeutic index generic immunosuppressant in solid organ transplantation is controversial. Most experiences switching to these drugs have short term follow-up periods, analyze only pharmacokinetic issues and do not systematically include either complications or cost...

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Autores principales:	GONZÁLEZ,FRANCISCA, GONZÁLEZ,FERNANDO
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Costs and Cost Analysis Drugs, Generic Immunosuppressive Agents Transplantation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000400429
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spelling	oai:scielo:S0034-988720200004004292020-07-07Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renalGONZÁLEZ,FRANCISCAGONZÁLEZ,FERNANDO Costs and Cost Analysis Drugs, Generic Immunosuppressive Agents Transplantation Background The use of narrow therapeutic index generic immunosuppressant in solid organ transplantation is controversial. Most experiences switching to these drugs have short term follow-up periods, analyze only pharmacokinetic issues and do not systematically include either complications or cost analyses. Aim To analyze the costs and benefits of switching our kidney transplant recipients from innovative tacrolimus to a generic version of the drug. Material and Methods Fifty-seven stable transplant recipients were switched from innovative tacrolimus to a generic version of the drug, maintaining the same dose. They were followed for eight months recording all events during such period. Results We observed two infectious episodes, five allograft biopsies were performed and two patients had acute rejections. Conclusions From the payer’s perspective, if all the costs associated with the change to generic tacrolimus are considered, savings related to a lower cost of the drug translate in a real financial loss for the public health system. The analysis also showed that frequent switches, even from one generic drug to a cheaper one is an even worse strategy to save money.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.4 20202020-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000400429es10.4067/s0034-98872020000400429
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Costs and Cost Analysis Drugs, Generic Immunosuppressive Agents Transplantation
spellingShingle	Costs and Cost Analysis Drugs, Generic Immunosuppressive Agents Transplantation GONZÁLEZ,FRANCISCA GONZÁLEZ,FERNANDO Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal
description	Background The use of narrow therapeutic index generic immunosuppressant in solid organ transplantation is controversial. Most experiences switching to these drugs have short term follow-up periods, analyze only pharmacokinetic issues and do not systematically include either complications or cost analyses. Aim To analyze the costs and benefits of switching our kidney transplant recipients from innovative tacrolimus to a generic version of the drug. Material and Methods Fifty-seven stable transplant recipients were switched from innovative tacrolimus to a generic version of the drug, maintaining the same dose. They were followed for eight months recording all events during such period. Results We observed two infectious episodes, five allograft biopsies were performed and two patients had acute rejections. Conclusions From the payer’s perspective, if all the costs associated with the change to generic tacrolimus are considered, savings related to a lower cost of the drug translate in a real financial loss for the public health system. The analysis also showed that frequent switches, even from one generic drug to a cheaper one is an even worse strategy to save money.
author	GONZÁLEZ,FRANCISCA GONZÁLEZ,FERNANDO
author_facet	GONZÁLEZ,FRANCISCA GONZÁLEZ,FERNANDO
author_sort	GONZÁLEZ,FRANCISCA
title	Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal
title_short	Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal
title_full	Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal
title_fullStr	Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal
title_full_unstemmed	Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal
title_sort	estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000400429
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Estimación del ahorro hospitalario con el reemplazo de inmunosupresores genéricos en trasplante renal

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