Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case

Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case

ABSTRACT Hyperthyroidism can induce elevation in several liver function tests including aminotransferases, alkaline phosphatases and, less frequently, serum bilirubin. These alterations are usually mild and asymptomatic. We report a 26 year-old male presenting with palpitations, progressive jaundice...

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Autores principales: Barra,María I., Olmos,Roberto, Barrera,Francisco, Mosso,Lorena, Domínguez,José M.
Lenguaje:English
Publicado: Sociedad Médica de Santiago 2020
Materias:
Graves Disease
Hyperbilirubinemia
Hyperthyroidism
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000500697
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spelling oai:scielo:S0034-988720200005006972020-09-29Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one caseBarra,María I.Olmos,RobertoBarrera,FranciscoMosso,LorenaDomínguez,José M. Graves Disease Hyperbilirubinemia Hyperthyroidism ABSTRACT Hyperthyroidism can induce elevation in several liver function tests including aminotransferases, alkaline phosphatases and, less frequently, serum bilirubin. These alterations are usually mild and asymptomatic. We report a 26 year-old male presenting with palpitations, progressive jaundice, choluria and generalized itching. Laboratory tests were compatible with hyperthyroidism and a mild elevation of bilirubin, alkaline phosphatases and gamma glutamyl transpeptidase. A liver biopsy showed portal hepatitis with canalicular cholestasis. The patient was treated temporarily with glucocorticoids, cholestyramine and betablockade. Thereafter, he was treated with radioactive iodine, after which serum bilirubin decreased steadily until normalization in ten weeks.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.5 20202020-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000500697en10.4067/S0034-98872020000500697
institution Scielo Chile
collection Scielo Chile
language English
topic Graves Disease
Hyperbilirubinemia
Hyperthyroidism
spellingShingle Graves Disease
Hyperbilirubinemia
Hyperthyroidism
Barra,María I.
Olmos,Roberto
Barrera,Francisco
Mosso,Lorena
Domínguez,José M.
Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case
description ABSTRACT Hyperthyroidism can induce elevation in several liver function tests including aminotransferases, alkaline phosphatases and, less frequently, serum bilirubin. These alterations are usually mild and asymptomatic. We report a 26 year-old male presenting with palpitations, progressive jaundice, choluria and generalized itching. Laboratory tests were compatible with hyperthyroidism and a mild elevation of bilirubin, alkaline phosphatases and gamma glutamyl transpeptidase. A liver biopsy showed portal hepatitis with canalicular cholestasis. The patient was treated temporarily with glucocorticoids, cholestyramine and betablockade. Thereafter, he was treated with radioactive iodine, after which serum bilirubin decreased steadily until normalization in ten weeks.
author Barra,María I.
Olmos,Roberto
Barrera,Francisco
Mosso,Lorena
Domínguez,José M.
author_facet Barra,María I.
Olmos,Roberto
Barrera,Francisco
Mosso,Lorena
Domínguez,José M.
author_sort Barra,María I.
title Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case
title_short Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case
title_full Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case
title_fullStr Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case
title_full_unstemmed Cholestasis secondary to hyperthyroidism in Graves’ disease. Report of one case
title_sort cholestasis secondary to hyperthyroidism in graves’ disease. report of one case
publisher Sociedad Médica de Santiago
publishDate 2020
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000500697
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AT barrerafrancisco cholestasissecondarytohyperthyroidismingraves8217diseasereportofonecase
AT mossolorena cholestasissecondarytohyperthyroidismingraves8217diseasereportofonecase
AT dominguezjosem cholestasissecondarytohyperthyroidismingraves8217diseasereportofonecase
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