Adherence to levothyroxine prescription in patients with hypothyroidism

ABSTRACT Background: Hypothyroidism occurs in 1-2% of the general population, is associated with significant morbidity and requires continuous treatment with levothyroxine. Aim: To determine the effectiveness, adherence and safety of levothyroxine therapy in patients with hypothyroidism. Material...

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Autores principales:	Machado-Alba,Jorge E., Machado-Duque,Manuel E.
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Hypothyroidism Pharmacoepidemiology Thyroxine Treatment Adherence and Compliance
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000600740
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spelling	oai:scielo:S0034-988720200006007402020-09-29Adherence to levothyroxine prescription in patients with hypothyroidismMachado-Alba,Jorge E.Machado-Duque,Manuel E. Hypothyroidism Pharmacoepidemiology Thyroxine Treatment Adherence and Compliance ABSTRACT Background: Hypothyroidism occurs in 1-2% of the general population, is associated with significant morbidity and requires continuous treatment with levothyroxine. Aim: To determine the effectiveness, adherence and safety of levothyroxine therapy in patients with hypothyroidism. Material and Methods: The Morisky-Green adherence test was applied, and effectiveness was determined by measuring thyroid-stimulating hormone (TSH) in 330 patients with with hypothyroidism; the mean age was 64+-15 years and 76% was women. Results: Median TSH was 2.09 mIU/L (interquartile range: 1.16-3.61 mIU/L). Two hundred thirty-five (71%) patients had TSH levels in the euthyroid range, 64 (19%) in the hypothyroid range and 31 (9%) in the hyperthyroid range. Complete, moderate and lack of adherence with levothyroxine was reported in 283 (86%), 29 (9%) and 18 (5%) of patients, respectively. The presence of anemia (odds ratio (OR): 0.37, 95% confidence intervals (CI): 0.15-0.98) or the need of doses over 100 µg/day (OR: 0.47, 95%CI: 0.28-0.80) increased the probability of having an abnormal TSH level. Conclusions: In a large proportion of these patients, TSH levels were controlled, and most patients were adherent to levothyroxine therapy.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.6 20202020-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000600740en10.4067/S0034-98872020000600740
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hypothyroidism Pharmacoepidemiology Thyroxine Treatment Adherence and Compliance
spellingShingle	Hypothyroidism Pharmacoepidemiology Thyroxine Treatment Adherence and Compliance Machado-Alba,Jorge E. Machado-Duque,Manuel E. Adherence to levothyroxine prescription in patients with hypothyroidism
description	ABSTRACT Background: Hypothyroidism occurs in 1-2% of the general population, is associated with significant morbidity and requires continuous treatment with levothyroxine. Aim: To determine the effectiveness, adherence and safety of levothyroxine therapy in patients with hypothyroidism. Material and Methods: The Morisky-Green adherence test was applied, and effectiveness was determined by measuring thyroid-stimulating hormone (TSH) in 330 patients with with hypothyroidism; the mean age was 64+-15 years and 76% was women. Results: Median TSH was 2.09 mIU/L (interquartile range: 1.16-3.61 mIU/L). Two hundred thirty-five (71%) patients had TSH levels in the euthyroid range, 64 (19%) in the hypothyroid range and 31 (9%) in the hyperthyroid range. Complete, moderate and lack of adherence with levothyroxine was reported in 283 (86%), 29 (9%) and 18 (5%) of patients, respectively. The presence of anemia (odds ratio (OR): 0.37, 95% confidence intervals (CI): 0.15-0.98) or the need of doses over 100 µg/day (OR: 0.47, 95%CI: 0.28-0.80) increased the probability of having an abnormal TSH level. Conclusions: In a large proportion of these patients, TSH levels were controlled, and most patients were adherent to levothyroxine therapy.
author	Machado-Alba,Jorge E. Machado-Duque,Manuel E.
author_facet	Machado-Alba,Jorge E. Machado-Duque,Manuel E.
author_sort	Machado-Alba,Jorge E.
title	Adherence to levothyroxine prescription in patients with hypothyroidism
title_short	Adherence to levothyroxine prescription in patients with hypothyroidism
title_full	Adherence to levothyroxine prescription in patients with hypothyroidism
title_fullStr	Adherence to levothyroxine prescription in patients with hypothyroidism
title_full_unstemmed	Adherence to levothyroxine prescription in patients with hypothyroidism
title_sort	adherence to levothyroxine prescription in patients with hypothyroidism
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000600740
work_keys_str_mv	AT machadoalbajorgee adherencetolevothyroxineprescriptioninpatientswithhypothyroidism AT machadoduquemanuele adherencetolevothyroxineprescriptioninpatientswithhypothyroidism
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Adherence to levothyroxine prescription in patients with hypothyroidism

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