Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecular

Pancreatic metastases of papillary thyroid carcinoma (PTC) are exceptional. We report a 80-year-old man consulting for obstructive jaundice and dysphonia. Abdominal ultrasonography showed biliary dilation and abdominal magnetic resonance imaging (MRI) showed a pancreatic head mass of 36 mm. A left v...

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Autores principales:	Uslar,Thomas, Chahuán,Javier, Olmos,Roberto, Rodríguez,Carolina, Astudillo,Rocio, Zoroquiain,Pablo, Solar,Antonieta, Espino,Alberto, León,Augusto, Fardella,Carlos, Domínguez,José Miguel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Endoscopic Ultrasound-Guided Fine Needle Aspiration Proto-Oncogene Proteins B-raf Thyroid Cancer, Papillary
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000701025
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spelling	oai:scielo:S0034-988720200007010252020-10-09Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecularUslar,ThomasChahuán,JavierOlmos,RobertoRodríguez,CarolinaAstudillo,RocioZoroquiain,PabloSolar,AntonietaEspino,AlbertoLeón,AugustoFardella,CarlosDomínguez,José Miguel Endoscopic Ultrasound-Guided Fine Needle Aspiration Proto-Oncogene Proteins B-raf Thyroid Cancer, Papillary Pancreatic metastases of papillary thyroid carcinoma (PTC) are exceptional. We report a 80-year-old man consulting for obstructive jaundice and dysphonia. Abdominal ultrasonography showed biliary dilation and abdominal magnetic resonance imaging (MRI) showed a pancreatic head mass of 36 mm. A left vocal cord paralysis was confirmed and cervical computed tomography (CT) showed multiple thyroid nodules of up to 35 mm associated with bilateral cervical lymph nodes (LN). Positron emission tomography ( 18 F-FDG PET/CT) evidenced hyper-metabolic activity in bilateral cervical LN, lungs, pancreas and left intercostal soft tissue, as well as left gluteus. Thyroid biopsy reported a tall-cell variant of PTC, and endoscopic ultrasound guided fine needle aspiration (EUS-FNA) of pancreatic mass confirmed PTC metastasis. The molecular study was positive for BRAFV600E. Pancreatic metastasis from PTC can be accurately diagnosed with 18 F-FDG PET/CT and EUS-FNA, which is consistent with a predominant expression of BRAFV600E mutation and, thus, an aggressive presentation with poor short-term survival.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.7 20202020-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000701025es10.4067/S0034-98872020000701025
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Endoscopic Ultrasound-Guided Fine Needle Aspiration Proto-Oncogene Proteins B-raf Thyroid Cancer, Papillary
spellingShingle	Endoscopic Ultrasound-Guided Fine Needle Aspiration Proto-Oncogene Proteins B-raf Thyroid Cancer, Papillary Uslar,Thomas Chahuán,Javier Olmos,Roberto Rodríguez,Carolina Astudillo,Rocio Zoroquiain,Pablo Solar,Antonieta Espino,Alberto León,Augusto Fardella,Carlos Domínguez,José Miguel Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecular
description	Pancreatic metastases of papillary thyroid carcinoma (PTC) are exceptional. We report a 80-year-old man consulting for obstructive jaundice and dysphonia. Abdominal ultrasonography showed biliary dilation and abdominal magnetic resonance imaging (MRI) showed a pancreatic head mass of 36 mm. A left vocal cord paralysis was confirmed and cervical computed tomography (CT) showed multiple thyroid nodules of up to 35 mm associated with bilateral cervical lymph nodes (LN). Positron emission tomography ( 18 F-FDG PET/CT) evidenced hyper-metabolic activity in bilateral cervical LN, lungs, pancreas and left intercostal soft tissue, as well as left gluteus. Thyroid biopsy reported a tall-cell variant of PTC, and endoscopic ultrasound guided fine needle aspiration (EUS-FNA) of pancreatic mass confirmed PTC metastasis. The molecular study was positive for BRAFV600E. Pancreatic metastasis from PTC can be accurately diagnosed with 18 F-FDG PET/CT and EUS-FNA, which is consistent with a predominant expression of BRAFV600E mutation and, thus, an aggressive presentation with poor short-term survival.
author	Uslar,Thomas Chahuán,Javier Olmos,Roberto Rodríguez,Carolina Astudillo,Rocio Zoroquiain,Pablo Solar,Antonieta Espino,Alberto León,Augusto Fardella,Carlos Domínguez,José Miguel
author_facet	Uslar,Thomas Chahuán,Javier Olmos,Roberto Rodríguez,Carolina Astudillo,Rocio Zoroquiain,Pablo Solar,Antonieta Espino,Alberto León,Augusto Fardella,Carlos Domínguez,José Miguel
author_sort	Uslar,Thomas
title	Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecular
title_short	Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecular
title_full	Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecular
title_fullStr	Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecular
title_full_unstemmed	Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecular
title_sort	metástasis pancreática como debut de carcinoma papilar de tiroides. caso clínico y revisión del perfil clínico patológico y molecular
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000701025
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Metástasis pancreática como debut de carcinoma papilar de tiroides. Caso clínico y revisión del perfil clínico patológico y molecular

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