Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos

Biological therapy dramatically changed the management of Ulcerative Colitis (UC). However, a significant number of these patients fail to respond or have secondary loss of response to this strategy. In this clinical situation, the options include intensification of anti-TNF therapy, the use of a se...

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Autores principales:	Quera,Rodrigo, Flores,Lilian, Núñez,Paulina, Ibáñez,Patricio
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Ulcerative colitis Inflammatory Bowel Diseases Janus Kinases Therapeutics
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000701039
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spelling	oai:scielo:S0034-988720200007010392020-10-09Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicosQuera,RodrigoFlores,LilianNúñez,PaulinaIbáñez,Patricio Ulcerative colitis Inflammatory Bowel Diseases Janus Kinases Therapeutics Biological therapy dramatically changed the management of Ulcerative Colitis (UC). However, a significant number of these patients fail to respond or have secondary loss of response to this strategy. In this clinical situation, the options include intensification of anti-TNF therapy, the use of a second anti-TNF or being switched to another drug class. Among the later, tofacitinib, an oral small molecule directed against the JAK/STAT pathway, is safe and effective in inducing and maintaining remission in patients with moderate-severe UC. We report two patients with UC refractory to conventional treatment and biological therapy, who responded successfully to the use of tofacitinib.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.7 20202020-07-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000701039es10.4067/S0034-98872020000701039
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Ulcerative colitis Inflammatory Bowel Diseases Janus Kinases Therapeutics
spellingShingle	Ulcerative colitis Inflammatory Bowel Diseases Janus Kinases Therapeutics Quera,Rodrigo Flores,Lilian Núñez,Paulina Ibáñez,Patricio Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos
description	Biological therapy dramatically changed the management of Ulcerative Colitis (UC). However, a significant number of these patients fail to respond or have secondary loss of response to this strategy. In this clinical situation, the options include intensification of anti-TNF therapy, the use of a second anti-TNF or being switched to another drug class. Among the later, tofacitinib, an oral small molecule directed against the JAK/STAT pathway, is safe and effective in inducing and maintaining remission in patients with moderate-severe UC. We report two patients with UC refractory to conventional treatment and biological therapy, who responded successfully to the use of tofacitinib.
author	Quera,Rodrigo Flores,Lilian Núñez,Paulina Ibáñez,Patricio
author_facet	Quera,Rodrigo Flores,Lilian Núñez,Paulina Ibáñez,Patricio
author_sort	Quera,Rodrigo
title	Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos
title_short	Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos
title_full	Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos
title_fullStr	Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos
title_full_unstemmed	Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos
title_sort	tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000701039
work_keys_str_mv	AT querarodrigo tofacitinibeneltratamientodelacolitisulcerosacasosclinicos AT floreslilian tofacitinibeneltratamientodelacolitisulcerosacasosclinicos AT nunezpaulina tofacitinibeneltratamientodelacolitisulcerosacasosclinicos AT ibanezpatricio tofacitinibeneltratamientodelacolitisulcerosacasosclinicos
_version_	1718437142196125696

Tofacitinib en el tratamiento de la colitis ulcerosa: casos clínicos

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