Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en Chile

Background: Vitamin K antagonist medications (VKA) are essential for the prevention of thromboembolic events, but their effectiveness is influenced by multiple factors, such as the type of medication chosen. Aim: To evaluate the efficacy in anticoagulant control of the bioequivalent and non-bioequ...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Rodríguez,David, Nieto,Elena, Quiroga,Teresa, Rojas,Eric, Vera,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Acenocoumarol Anticoagulants Therapeutic Equivalency Warfarin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000901254
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:scielo:S0034-98872020000901254
record_format	dspace
spelling	oai:scielo:S0034-988720200009012542020-12-26Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en ChileRodríguez,DavidNieto,ElenaQuiroga,TeresaRojas,EricVera,Francisco Acenocoumarol Anticoagulants Therapeutic Equivalency Warfarin Background: Vitamin K antagonist medications (VKA) are essential for the prevention of thromboembolic events, but their effectiveness is influenced by multiple factors, such as the type of medication chosen. Aim: To evaluate the efficacy in anticoagulant control of the bioequivalent and non-bioequivalent drugs of acenocoumarol compared to the reference drug. To evaluate the efficacy of warfarin bioequivalents available in Chile. To contrast the overall anticoagulant control efficacy between acenocoumarol and warfarin. Material and Methods: The results of 69333 outpatient oral anticoagulation controls were analyzed. Patient were separated in groups according to the drug that they used. Subsequently, the proportions of controls outside the range for each of acenocoumarol and warfarin bioequivalent drugs were compared. Acenocoumarol non-bioequivalent drugs were also compared with the reference drug. Acenocoumarol was compared with warfarin. Results: Acenocoumarol bioequivalent drugs and the reference drug had a similar proportion of controls outside the range (Odds ratios (OR) 0.812; 0.969; 0.974 and 0.963). Non-bioequivalent drugs had a higher proportion than the reference drug (OR 1.561 and 2.037). Both warfarin brands have a similar proportion of controls outside of the range (OR 1.050). Acenocoumarol compared to warfarin had a significant higher proportion of controls outside the range (OR 1.191). Conclusions: The pharmacological presentation of vitamin K antagonists could influence anticoagulant control. Therefore, it is not prudent to switch these presentations frequently.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.9 20202020-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000901254es10.4067/S0034-98872020000901254
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Acenocoumarol Anticoagulants Therapeutic Equivalency Warfarin
spellingShingle	Acenocoumarol Anticoagulants Therapeutic Equivalency Warfarin Rodríguez,David Nieto,Elena Quiroga,Teresa Rojas,Eric Vera,Francisco Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en Chile
description	Background: Vitamin K antagonist medications (VKA) are essential for the prevention of thromboembolic events, but their effectiveness is influenced by multiple factors, such as the type of medication chosen. Aim: To evaluate the efficacy in anticoagulant control of the bioequivalent and non-bioequivalent drugs of acenocoumarol compared to the reference drug. To evaluate the efficacy of warfarin bioequivalents available in Chile. To contrast the overall anticoagulant control efficacy between acenocoumarol and warfarin. Material and Methods: The results of 69333 outpatient oral anticoagulation controls were analyzed. Patient were separated in groups according to the drug that they used. Subsequently, the proportions of controls outside the range for each of acenocoumarol and warfarin bioequivalent drugs were compared. Acenocoumarol non-bioequivalent drugs were also compared with the reference drug. Acenocoumarol was compared with warfarin. Results: Acenocoumarol bioequivalent drugs and the reference drug had a similar proportion of controls outside the range (Odds ratios (OR) 0.812; 0.969; 0.974 and 0.963). Non-bioequivalent drugs had a higher proportion than the reference drug (OR 1.561 and 2.037). Both warfarin brands have a similar proportion of controls outside of the range (OR 1.050). Acenocoumarol compared to warfarin had a significant higher proportion of controls outside the range (OR 1.191). Conclusions: The pharmacological presentation of vitamin K antagonists could influence anticoagulant control. Therefore, it is not prudent to switch these presentations frequently.
author	Rodríguez,David Nieto,Elena Quiroga,Teresa Rojas,Eric Vera,Francisco
author_facet	Rodríguez,David Nieto,Elena Quiroga,Teresa Rojas,Eric Vera,Francisco
author_sort	Rodríguez,David
title	Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en Chile
title_short	Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en Chile
title_full	Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en Chile
title_fullStr	Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en Chile
title_full_unstemmed	Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en Chile
title_sort	eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina k disponibles en chile
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020000901254
work_keys_str_mv	AT rodriguezdavid eficaciaenelcontroldelaanticoagulaciondelosdiferentesfarmacosantagonistasdelavitaminakdisponiblesenchile AT nietoelena eficaciaenelcontroldelaanticoagulaciondelosdiferentesfarmacosantagonistasdelavitaminakdisponiblesenchile AT quirogateresa eficaciaenelcontroldelaanticoagulaciondelosdiferentesfarmacosantagonistasdelavitaminakdisponiblesenchile AT rojaseric eficaciaenelcontroldelaanticoagulaciondelosdiferentesfarmacosantagonistasdelavitaminakdisponiblesenchile AT verafrancisco eficaciaenelcontroldelaanticoagulaciondelosdiferentesfarmacosantagonistasdelavitaminakdisponiblesenchile
_version_	1718437150462050304

Eficacia en el control de la anticoagulación de los diferentes fármacos antagonistas de la vitamina K disponibles en Chile

Ejemplares similares