Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2

Background: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China and the world. Aim: To describe the clinical features, risk factors, and predictors of hospitalization in adult patients treated for acute respiratory infections associated w...

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Autores principales:	Saldías Peñafiel,Fernando, Peñaloza Tapia,Alejandro, Farías Nesvadba,Daniela, Farcas Oksenberg,Katia, Reyes Sánchez,Antonia, Cortés Meza,Josefina, Lara Hernández,Bárbara, Aguilera Fuenzalida,Pablo, Leiva Rodríguez,Isabel
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Coronavirus SARS-CoV-2 Diagnosis Prognosis Predictive Value of Tests
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001387
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spelling	oai:scielo:S0034-988720200010013872021-02-02Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2Saldías Peñafiel,FernandoPeñaloza Tapia,AlejandroFarías Nesvadba,DanielaFarcas Oksenberg,KatiaReyes Sánchez,AntoniaCortés Meza,JosefinaLara Hernández,BárbaraAguilera Fuenzalida,PabloLeiva Rodríguez,Isabel Coronavirus SARS-CoV-2 Diagnosis Prognosis Predictive Value of Tests Background: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China and the world. Aim: To describe the clinical features, risk factors, and predictors of hospitalization in adult patients treated for acute respiratory infections associated with coronavirus SARS-CoV-2. Material and Methods: Descriptive prospective study of ambulatory and hospitalized adult patients with confirmed COVID-19 attended between April 1 and May 31, 2020. Clinical features, chronic comorbidities and demographic data were recorded, and patients were followed for two months as outpatients. Results: We assessed 1,022 adults aged 41 ± 14 years (50% men) with laboratory-confirmed COVID-19. One-third had comorbidities, specially hypertension (12.5%), hypothyroidism (6.6%), asthma (5.4%) and diabetes (4.5%). Hospital admission was required in 11%, 5.2% were admitted to critical care unit and 0.9% were connected to mechanical ventilation. Common symptoms included fatigue (55.4%), fever (52.5%), headache (68.6%), anosmia/dysgeusia (53.2%), dry cough (53.4%), dyspnea (27.4%) and diarrhea (35.5%). One third of patients reported persistence of symptoms at one-month follow-up, specially fatigue, cough and dyspnea. In the multivariate analysis, age, fever, cough, dyspnea and immunosuppression were associated with hospitalization and ICU admission. Age, male sex and moderate-severe dyspnea were associated with requirement of mechanical ventilation. The main predictors of prolonged clinical course were female sex, presence of comorbidities, history of dyspnea, cough, myalgia and abdominal pain. Conclusions: Clinical features of COVID-19 were highly unspecific. Prediction models for severity, will help medical decision making at the primary care setting.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.10 20202020-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001387es10.4067/S0034-98872020001001387
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Coronavirus SARS-CoV-2 Diagnosis Prognosis Predictive Value of Tests
spellingShingle	Coronavirus SARS-CoV-2 Diagnosis Prognosis Predictive Value of Tests Saldías Peñafiel,Fernando Peñaloza Tapia,Alejandro Farías Nesvadba,Daniela Farcas Oksenberg,Katia Reyes Sánchez,Antonia Cortés Meza,Josefina Lara Hernández,Bárbara Aguilera Fuenzalida,Pablo Leiva Rodríguez,Isabel Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2
description	Background: In December 2019, coronavirus disease 2019 (COVID-19) emerged in Wuhan city and spread rapidly throughout China and the world. Aim: To describe the clinical features, risk factors, and predictors of hospitalization in adult patients treated for acute respiratory infections associated with coronavirus SARS-CoV-2. Material and Methods: Descriptive prospective study of ambulatory and hospitalized adult patients with confirmed COVID-19 attended between April 1 and May 31, 2020. Clinical features, chronic comorbidities and demographic data were recorded, and patients were followed for two months as outpatients. Results: We assessed 1,022 adults aged 41 ± 14 years (50% men) with laboratory-confirmed COVID-19. One-third had comorbidities, specially hypertension (12.5%), hypothyroidism (6.6%), asthma (5.4%) and diabetes (4.5%). Hospital admission was required in 11%, 5.2% were admitted to critical care unit and 0.9% were connected to mechanical ventilation. Common symptoms included fatigue (55.4%), fever (52.5%), headache (68.6%), anosmia/dysgeusia (53.2%), dry cough (53.4%), dyspnea (27.4%) and diarrhea (35.5%). One third of patients reported persistence of symptoms at one-month follow-up, specially fatigue, cough and dyspnea. In the multivariate analysis, age, fever, cough, dyspnea and immunosuppression were associated with hospitalization and ICU admission. Age, male sex and moderate-severe dyspnea were associated with requirement of mechanical ventilation. The main predictors of prolonged clinical course were female sex, presence of comorbidities, history of dyspnea, cough, myalgia and abdominal pain. Conclusions: Clinical features of COVID-19 were highly unspecific. Prediction models for severity, will help medical decision making at the primary care setting.
author	Saldías Peñafiel,Fernando Peñaloza Tapia,Alejandro Farías Nesvadba,Daniela Farcas Oksenberg,Katia Reyes Sánchez,Antonia Cortés Meza,Josefina Lara Hernández,Bárbara Aguilera Fuenzalida,Pablo Leiva Rodríguez,Isabel
author_facet	Saldías Peñafiel,Fernando Peñaloza Tapia,Alejandro Farías Nesvadba,Daniela Farcas Oksenberg,Katia Reyes Sánchez,Antonia Cortés Meza,Josefina Lara Hernández,Bárbara Aguilera Fuenzalida,Pablo Leiva Rodríguez,Isabel
author_sort	Saldías Peñafiel,Fernando
title	Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2
title_short	Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2
title_full	Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2
title_fullStr	Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2
title_full_unstemmed	Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2
title_sort	manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus sars-cov-2
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001387
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Manifestaciones clínicas y predictores de gravedad en pacientes adultos con infección respiratoria aguda por coronavirus SARS-CoV-2

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