Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoria

Coronavirus disease 19 is characterized by an intense inflammatory response and a high incidence of thrombotic events. Autopsy studies show severe endothelial injury associated with thrombosis of the alveolar capillaries of the lungs and other organs. In the pathophysiology of this disease endotheli...

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Autores principales:	Samaniego,Francisco, Conte,Guillermo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Coronavirus Disseminated Intravascular Coagulation Thrombosis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001467
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spelling	oai:scielo:S0034-988720200010014672021-02-02Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoriaSamaniego,FranciscoConte,Guillermo Coronavirus Disseminated Intravascular Coagulation Thrombosis Coronavirus disease 19 is characterized by an intense inflammatory response and a high incidence of thrombotic events. Autopsy studies show severe endothelial injury associated with thrombosis of the alveolar capillaries of the lungs and other organs. In the pathophysiology of this disease endothelial injury and dysfunction, inflammation and thrombosis are key factors for the development of severe phenotypes. Therefore, we should consider this entity as a systemic endothelial disease in which an obstructive microvascular syndrome secondary to an intense thrombo-inflammatory response leads to acute respiratory insufficiency and multiorgan failure. Heparin is an excellent drug to treat Covid-19 patients due to its anticoagulant, anti-inflammatory, antiviral and endothelial effects. Clinical guidelines agree that the use of heparin thromboprophylaxis is a component of Covid-19 coagulopathy treatment, even though the dose and duration of treatments are not well defined.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.10 20202020-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001467es10.4067/S0034-98872020001001467
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Coronavirus Disseminated Intravascular Coagulation Thrombosis
spellingShingle	Coronavirus Disseminated Intravascular Coagulation Thrombosis Samaniego,Francisco Conte,Guillermo Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoria
description	Coronavirus disease 19 is characterized by an intense inflammatory response and a high incidence of thrombotic events. Autopsy studies show severe endothelial injury associated with thrombosis of the alveolar capillaries of the lungs and other organs. In the pathophysiology of this disease endothelial injury and dysfunction, inflammation and thrombosis are key factors for the development of severe phenotypes. Therefore, we should consider this entity as a systemic endothelial disease in which an obstructive microvascular syndrome secondary to an intense thrombo-inflammatory response leads to acute respiratory insufficiency and multiorgan failure. Heparin is an excellent drug to treat Covid-19 patients due to its anticoagulant, anti-inflammatory, antiviral and endothelial effects. Clinical guidelines agree that the use of heparin thromboprophylaxis is a component of Covid-19 coagulopathy treatment, even though the dose and duration of treatments are not well defined.
author	Samaniego,Francisco Conte,Guillermo
author_facet	Samaniego,Francisco Conte,Guillermo
author_sort	Samaniego,Francisco
title	Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoria
title_short	Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoria
title_full	Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoria
title_fullStr	Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoria
title_full_unstemmed	Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoria
title_sort	infección por sars-cov-2. una nueva enfermedad endotelial trombo-inflamatoria
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001467
work_keys_str_mv	AT samaniegofrancisco infeccionporsarscov2unanuevaenfermedadendotelialtromboinflamatoria AT conteguillermo infeccionporsarscov2unanuevaenfermedadendotelialtromboinflamatoria
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Infección por SARS-CoV-2. Una nueva enfermedad endotelial trombo-inflamatoria

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