Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?

Von Willebrand factor (vWf) is a fundamental multimeric plasma glycoprotein in the coagulation process. Its function is to mediate platelet adhesion and to stabilize circulating factor VIII. A functional or quantitative alteration of vWf gives rise to von Willebrand disease (vWD). The association be...

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Autores principales:	Salinas Laval,José, Triantafilo,Nicolás, Zúñiga,Pamela
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Angiodysplasia Gastrointestinal Hemorrhage von Willebrand Diseases
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001475
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spelling	oai:scielo:S0034-988720200010014752021-02-02Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?Salinas Laval,JoséTriantafilo,NicolásZúñiga,Pamela Angiodysplasia Gastrointestinal Hemorrhage von Willebrand Diseases Von Willebrand factor (vWf) is a fundamental multimeric plasma glycoprotein in the coagulation process. Its function is to mediate platelet adhesion and to stabilize circulating factor VIII. A functional or quantitative alteration of vWf gives rise to von Willebrand disease (vWD). The association between vWD and angiodysplasia was described in 1967, but it was only until 2011 that Starke et al demonstrated the in vitro and in vivo role of vWf in angiogenesis. Congenital or acquired vWf deficiency, especially of high molecular weight multimeters, not only favors bleeding, but also contributes to increased angiogenesis in these patients. The treatment should be focused both on the control of the acute episode of gastrointestinal bleeding, with vWf replacement therapy and local endoscopic treatment, as well as on the prevention of the progression of angiodysplasia and future bleeding. There are different published therapeutic approaches using vWf replacement that are not effective in all patients. Recently, angiogenesis inhibitor medications have been used.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.10 20202020-10-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001475es10.4067/S0034-98872020001001475
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Angiodysplasia Gastrointestinal Hemorrhage von Willebrand Diseases
spellingShingle	Angiodysplasia Gastrointestinal Hemorrhage von Willebrand Diseases Salinas Laval,José Triantafilo,Nicolás Zúñiga,Pamela Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?
description	Von Willebrand factor (vWf) is a fundamental multimeric plasma glycoprotein in the coagulation process. Its function is to mediate platelet adhesion and to stabilize circulating factor VIII. A functional or quantitative alteration of vWf gives rise to von Willebrand disease (vWD). The association between vWD and angiodysplasia was described in 1967, but it was only until 2011 that Starke et al demonstrated the in vitro and in vivo role of vWf in angiogenesis. Congenital or acquired vWf deficiency, especially of high molecular weight multimeters, not only favors bleeding, but also contributes to increased angiogenesis in these patients. The treatment should be focused both on the control of the acute episode of gastrointestinal bleeding, with vWf replacement therapy and local endoscopic treatment, as well as on the prevention of the progression of angiodysplasia and future bleeding. There are different published therapeutic approaches using vWf replacement that are not effective in all patients. Recently, angiogenesis inhibitor medications have been used.
author	Salinas Laval,José Triantafilo,Nicolás Zúñiga,Pamela
author_facet	Salinas Laval,José Triantafilo,Nicolás Zúñiga,Pamela
author_sort	Salinas Laval,José
title	Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?
title_short	Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?
title_full	Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?
title_fullStr	Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?
title_full_unstemmed	Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?
title_sort	asociación entre enfermedad de von willebrand y angiodisplasia: ¿casualidad o causalidad?
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001001475
work_keys_str_mv	AT salinaslavaljose asociacionentreenfermedaddevonwillebrandyangiodisplasiacasualidadocausalidad AT triantafilonicolas asociacionentreenfermedaddevonwillebrandyangiodisplasiacasualidadocausalidad AT zunigapamela asociacionentreenfermedaddevonwillebrandyangiodisplasiacasualidadocausalidad
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Asociación entre enfermedad de von Willebrand y angiodisplasia: ¿casualidad o causalidad?

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