Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)

Background: The prognosis of Non-Hodgkin Lymphoma (NHL) depends on the type of lymphoma, the extension of the disease and the response to therapy. Aim: To evaluate the prognostic value of pretreatment and interim PET/CT compared to classic prognosis factors and body composition measurement (sarcop...

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Autores principales:	Guevara,David Ladrón de, Bernard,Sebastián, Manhood,Susana, Melani,Sophia, Yerovi,Fernando, Rodríguez,María de los Ángeles
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2020
Materias:	Lymphoma, Non-Hodgkin Multidetector Computed Tomography Prognosis Positron-Emission Tomography Survival
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101558
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spelling	oai:scielo:S0034-988720200011015582021-04-04Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)Guevara,David Ladrón deBernard,SebastiánManhood,SusanaMelani,SophiaYerovi,FernandoRodríguez,María de los Ángeles Lymphoma, Non-Hodgkin Multidetector Computed Tomography Prognosis Positron-Emission Tomography Survival Background: The prognosis of Non-Hodgkin Lymphoma (NHL) depends on the type of lymphoma, the extension of the disease and the response to therapy. Aim: To evaluate the prognostic value of pretreatment and interim PET/CT compared to classic prognosis factors and body composition measurement (sarcopenia, adipopenia) in patients with recently diagnosed NHL. Material and Methods: Patients with recently diagnosed NHL who had staging 18F-FDG PET/CT performed between December 2008 and August 2018 were selected. Age, gender, weight, height, B symptoms, laboratory tests, pathology, staging PET/CT findings (Ann Arbor, number of nodal groups and extranodal sites involved, Bulky, maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis), Computed Tomography findings (psoas muscle mass index, psoas area, psoas density, subcutaneous fat index (all of them at L3 level), and Deauville score (Lugano Criteria) were recorded. The prognostic value of each of these factors was assessed using Cox multivariable regressions. Results: Of 138 NHL studied patients (median 61 y, 15-87 y, 60.4% men), 31 of them died due to the disease. The median follow-up was 39 months (1-115 months). The strongest prognostic factors were: B symptoms (p < 0.01), anemia (p < 0.01), hypoalbuminemia (p: 0.01), sarcopenia (p < 0.01), adipopenia (p < 0.01), number of node groups involved (p < 0.01), MTV (p < 0.01), and a bad response in interim PET/CT (p < 0.01). In a comparative Cox multivariable analysis, interim PET/CT was the independent variable with the highest significance (p < 0.01). Conclusions: Early treatment response assessed by interim PET/CT is the strongest prognostic factor in NHL patients.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.11 20202020-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101558es10.4067/S0034-98872020001101558
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Lymphoma, Non-Hodgkin Multidetector Computed Tomography Prognosis Positron-Emission Tomography Survival
spellingShingle	Lymphoma, Non-Hodgkin Multidetector Computed Tomography Prognosis Positron-Emission Tomography Survival Guevara,David Ladrón de Bernard,Sebastián Manhood,Susana Melani,Sophia Yerovi,Fernando Rodríguez,María de los Ángeles Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)
description	Background: The prognosis of Non-Hodgkin Lymphoma (NHL) depends on the type of lymphoma, the extension of the disease and the response to therapy. Aim: To evaluate the prognostic value of pretreatment and interim PET/CT compared to classic prognosis factors and body composition measurement (sarcopenia, adipopenia) in patients with recently diagnosed NHL. Material and Methods: Patients with recently diagnosed NHL who had staging 18F-FDG PET/CT performed between December 2008 and August 2018 were selected. Age, gender, weight, height, B symptoms, laboratory tests, pathology, staging PET/CT findings (Ann Arbor, number of nodal groups and extranodal sites involved, Bulky, maximum standardized uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis), Computed Tomography findings (psoas muscle mass index, psoas area, psoas density, subcutaneous fat index (all of them at L3 level), and Deauville score (Lugano Criteria) were recorded. The prognostic value of each of these factors was assessed using Cox multivariable regressions. Results: Of 138 NHL studied patients (median 61 y, 15-87 y, 60.4% men), 31 of them died due to the disease. The median follow-up was 39 months (1-115 months). The strongest prognostic factors were: B symptoms (p < 0.01), anemia (p < 0.01), hypoalbuminemia (p: 0.01), sarcopenia (p < 0.01), adipopenia (p < 0.01), number of node groups involved (p < 0.01), MTV (p < 0.01), and a bad response in interim PET/CT (p < 0.01). In a comparative Cox multivariable analysis, interim PET/CT was the independent variable with the highest significance (p < 0.01). Conclusions: Early treatment response assessed by interim PET/CT is the strongest prognostic factor in NHL patients.
author	Guevara,David Ladrón de Bernard,Sebastián Manhood,Susana Melani,Sophia Yerovi,Fernando Rodríguez,María de los Ángeles
author_facet	Guevara,David Ladrón de Bernard,Sebastián Manhood,Susana Melani,Sophia Yerovi,Fernando Rodríguez,María de los Ángeles
author_sort	Guevara,David Ladrón de
title	Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)
title_short	Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)
title_full	Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)
title_fullStr	Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)
title_full_unstemmed	Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)
title_sort	valor pronóstico del pet/ct interino en linfoma no hodgkin en comparación con factores pronósticos clásicos (ipi) y de composición corporal (sarcopenia/lipopenia)
publisher	Sociedad Médica de Santiago
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101558
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Valor pronóstico del PET/CT interino en Linfoma no Hodgkin en comparación con factores pronósticos clásicos (IPI) y de composición corporal (sarcopenia/lipopenia)

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