Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center
ABSTRACT Background: During the first pandemic wave, Covid-19 reached Latin America cities. Aim: To report clinical features and outcomes of a group of patients with Covid-19 admitted to a Chilean regional reference Center. Material and Methods: Cases were identified by a compatible clinical pict...
Guardado en:
| Autores principales: | , , , , , , , , , |
|---|---|
| Lenguaje: | English |
| Publicado: |
Sociedad Médica de Santiago
2020
|
| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101577 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:scielo:S0034-98872020001101577 |
|---|---|
| record_format |
dspace |
| spelling |
oai:scielo:S0034-988720200011015772021-04-04Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference CenterOlivares,FelipeMuñoz,DanielFica,AlbertoDelama,IgnacioAlvarez,IgnaciaNavarrete,MaritzaBlackburn,EileenGarrido,PamelaWenger,RicardoGrandjean,Juan COVID-19 Critical Care Pneumonia Real-Time Polymerase Chain Reaction Serologic Tests ABSTRACT Background: During the first pandemic wave, Covid-19 reached Latin America cities. Aim: To report clinical features and outcomes of a group of patients with Covid-19 admitted to a Chilean regional reference Center. Material and Methods: Cases were identified by a compatible clinical picture and a positive PCR or serological test. Clinical features of patients were retrieved from medical records. Results: Forty-seven adult patients (45 diagnosed by PCR, 2 by serology) were admitted between epidemiological weeks 13 to 33, corresponding to 4.4% of total regional cases. Hospitalization occurred at a median of 10 days after onset of symptoms. Fifty one percent of patients had 60 years or more. Hypertension, obesity and diabetes mellitus were present in 57, 45 and 32 % of cases, respectively. Nineteen percent of patients had no comorbid condition nor were elderly. Two cases were women in their second trimester of pregnancy. Positive IgM or IgM/IgG results obtained by rapid serological testing, had limited sensitivity during the first week (67%). Seventeen patients (36.2%) were transferred to an intensive care unit (ICU) due to respiratory failure. Chest imaging demonstrated a classical COVID-19 pattern in 87%. By univariate analysis, admission to ICU was significantly associated with tachypnea and higher CALL (comorbidity, age, lymphocyte count and lactate dehydrogenase) score. Four patients died (rendering a hospital mortality of 8.5%) and length of stay was ≥ 14 days in 46.8% of patients. By univariate analysis, mortality was associated with immunosuppression and ICU admission. Conclusions: In our regional Center, patients admitted with COVID-19 had usual risk factors and had a prolonged stay. Hospital mortality was associated with immunosuppression and ICU admission.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.11 20202020-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101577en10.4067/S0034-98872020001101577 |
| institution |
Scielo Chile |
| collection |
Scielo Chile |
| language |
English |
| topic |
COVID-19 Critical Care Pneumonia Real-Time Polymerase Chain Reaction Serologic Tests |
| spellingShingle |
COVID-19 Critical Care Pneumonia Real-Time Polymerase Chain Reaction Serologic Tests Olivares,Felipe Muñoz,Daniel Fica,Alberto Delama,Ignacio Alvarez,Ignacia Navarrete,Maritza Blackburn,Eileen Garrido,Pamela Wenger,Ricardo Grandjean,Juan Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center |
| description |
ABSTRACT Background: During the first pandemic wave, Covid-19 reached Latin America cities. Aim: To report clinical features and outcomes of a group of patients with Covid-19 admitted to a Chilean regional reference Center. Material and Methods: Cases were identified by a compatible clinical picture and a positive PCR or serological test. Clinical features of patients were retrieved from medical records. Results: Forty-seven adult patients (45 diagnosed by PCR, 2 by serology) were admitted between epidemiological weeks 13 to 33, corresponding to 4.4% of total regional cases. Hospitalization occurred at a median of 10 days after onset of symptoms. Fifty one percent of patients had 60 years or more. Hypertension, obesity and diabetes mellitus were present in 57, 45 and 32 % of cases, respectively. Nineteen percent of patients had no comorbid condition nor were elderly. Two cases were women in their second trimester of pregnancy. Positive IgM or IgM/IgG results obtained by rapid serological testing, had limited sensitivity during the first week (67%). Seventeen patients (36.2%) were transferred to an intensive care unit (ICU) due to respiratory failure. Chest imaging demonstrated a classical COVID-19 pattern in 87%. By univariate analysis, admission to ICU was significantly associated with tachypnea and higher CALL (comorbidity, age, lymphocyte count and lactate dehydrogenase) score. Four patients died (rendering a hospital mortality of 8.5%) and length of stay was ≥ 14 days in 46.8% of patients. By univariate analysis, mortality was associated with immunosuppression and ICU admission. Conclusions: In our regional Center, patients admitted with COVID-19 had usual risk factors and had a prolonged stay. Hospital mortality was associated with immunosuppression and ICU admission. |
| author |
Olivares,Felipe Muñoz,Daniel Fica,Alberto Delama,Ignacio Alvarez,Ignacia Navarrete,Maritza Blackburn,Eileen Garrido,Pamela Wenger,Ricardo Grandjean,Juan |
| author_facet |
Olivares,Felipe Muñoz,Daniel Fica,Alberto Delama,Ignacio Alvarez,Ignacia Navarrete,Maritza Blackburn,Eileen Garrido,Pamela Wenger,Ricardo Grandjean,Juan |
| author_sort |
Olivares,Felipe |
| title |
Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center |
| title_short |
Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center |
| title_full |
Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center |
| title_fullStr |
Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center |
| title_full_unstemmed |
Clinical features of 47 patients infected with COVID-19 admitted to a Regional Reference Center |
| title_sort |
clinical features of 47 patients infected with covid-19 admitted to a regional reference center |
| publisher |
Sociedad Médica de Santiago |
| publishDate |
2020 |
| url |
http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101577 |
| work_keys_str_mv |
AT olivaresfelipe clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT munozdaniel clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT ficaalberto clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT delamaignacio clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT alvarezignacia clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT navarretemaritza clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT blackburneileen clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT garridopamela clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT wengerricardo clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter AT grandjeanjuan clinicalfeaturesof47patientsinfectedwithcovid19admittedtoaregionalreferencecenter |
| _version_ |
1718437163316543488 |