Uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-control

Background: Cannabis use among young people in Chile has increased significantly in the last years. There is a consistent link between cannabis and psychosis. Aim: To compare cannabis use in patients with a first episode of psychosis and healthy controls. Material and Methods: We included 74 pati...

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Autores principales: Castañeda,Carmen Paz, Alliende,Luz María, Iruretagoyena,Bárbara, Nachar,Rubén, Mancilla,Felipe, Díaz,Camila, Gallardo,Carlos, Mena,Cristián, Ramírez-Mahaluf,Juan Pablo, Undurraga,Juan, González-Valderrama,Alfonso, Crossley,Nicolás A.
Lenguaje:Spanish / Castilian
Publicado: Sociedad Médica de Santiago 2020
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101606
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spelling oai:scielo:S0034-988720200011016062021-04-04Uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-controlCastañeda,Carmen PazAlliende,Luz MaríaIruretagoyena,BárbaraNachar,RubénMancilla,FelipeDíaz,CamilaGallardo,CarlosMena,CristiánRamírez-Mahaluf,Juan PabloUndurraga,JuanGonzález-Valderrama,AlfonsoCrossley,Nicolás A. Cannabis Case-Control Studies Psychotic Disorders Background: Cannabis use among young people in Chile has increased significantly in the last years. There is a consistent link between cannabis and psychosis. Aim: To compare cannabis use in patients with a first episode of psychosis and healthy controls. Material and Methods: We included 74 patients aged 20 ± 3 years (78% males) admitted to hospital with a first episode of psychosis and a group of 60 healthy controls aged 23 ± 4 years (63% males). Cannabis consumption was assessed, including age of first time use and length of regular use. Results: Patients with psychosis reported a non-significantly higher frequency of life-time cannabis use. Patients had longer periods of regular cannabis use compared with healthy subjects (Odds ratio [OR] 2.4; 95% confi-dence intervals [CI] 1.14-5.05). Patients also used cannabis for the first time at an earlier age (16 compared with 17 years, p < 0.0). The population attributable fraction for regular cannabis use associated with hospital admissions due to psychosis was 17.7% (95% CI 1.2-45.5%). Conclusions: Cannabis use is related to psychosis in this Chilean group of patients. This relationship is stronger in patients with early exposure to the drug and longer the regular use. One of every five admissions due to psychosis is associated with cannabis consumption. These data should influence cannabis legisla-tion and the public policies currently being discussed in Chile.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.148 n.11 20202020-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101606es10.4067/S0034-98872020001101606
institution Scielo Chile
collection Scielo Chile
language Spanish / Castilian
topic Cannabis
Case-Control Studies
Psychotic Disorders
spellingShingle Cannabis
Case-Control Studies
Psychotic Disorders
Castañeda,Carmen Paz
Alliende,Luz María
Iruretagoyena,Bárbara
Nachar,Rubén
Mancilla,Felipe
Díaz,Camila
Gallardo,Carlos
Mena,Cristián
Ramírez-Mahaluf,Juan Pablo
Undurraga,Juan
González-Valderrama,Alfonso
Crossley,Nicolás A.
Uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-control
description Background: Cannabis use among young people in Chile has increased significantly in the last years. There is a consistent link between cannabis and psychosis. Aim: To compare cannabis use in patients with a first episode of psychosis and healthy controls. Material and Methods: We included 74 patients aged 20 ± 3 years (78% males) admitted to hospital with a first episode of psychosis and a group of 60 healthy controls aged 23 ± 4 years (63% males). Cannabis consumption was assessed, including age of first time use and length of regular use. Results: Patients with psychosis reported a non-significantly higher frequency of life-time cannabis use. Patients had longer periods of regular cannabis use compared with healthy subjects (Odds ratio [OR] 2.4; 95% confi-dence intervals [CI] 1.14-5.05). Patients also used cannabis for the first time at an earlier age (16 compared with 17 years, p < 0.0). The population attributable fraction for regular cannabis use associated with hospital admissions due to psychosis was 17.7% (95% CI 1.2-45.5%). Conclusions: Cannabis use is related to psychosis in this Chilean group of patients. This relationship is stronger in patients with early exposure to the drug and longer the regular use. One of every five admissions due to psychosis is associated with cannabis consumption. These data should influence cannabis legisla-tion and the public policies currently being discussed in Chile.
author Castañeda,Carmen Paz
Alliende,Luz María
Iruretagoyena,Bárbara
Nachar,Rubén
Mancilla,Felipe
Díaz,Camila
Gallardo,Carlos
Mena,Cristián
Ramírez-Mahaluf,Juan Pablo
Undurraga,Juan
González-Valderrama,Alfonso
Crossley,Nicolás A.
author_facet Castañeda,Carmen Paz
Alliende,Luz María
Iruretagoyena,Bárbara
Nachar,Rubén
Mancilla,Felipe
Díaz,Camila
Gallardo,Carlos
Mena,Cristián
Ramírez-Mahaluf,Juan Pablo
Undurraga,Juan
González-Valderrama,Alfonso
Crossley,Nicolás A.
author_sort Castañeda,Carmen Paz
title Uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-control
title_short Uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-control
title_full Uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-control
title_fullStr Uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-control
title_full_unstemmed Uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-control
title_sort uso de cannabis en jóvenes hospitalizados por un primer episodio de psicosis: un estudio caso-control
publisher Sociedad Médica de Santiago
publishDate 2020
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872020001101606
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