Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario

Background: The discovery of the phospholipase A2 receptor antigen and its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis and follow-up of patients with membranous nephropathy (MN). Thus, some international guidelines recommend not performing renal biopsy in patients with...

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Autores principales:	Frías Oyarzún,Alondra, Segura Hidalgo,Paula, Toro Cabrera,Luis, Elgueta Segura,Leticia, Torres Díaz,Rubén, Alvo Abodovsky,Miriam
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Glomerulonephritis, Membranous Immunohistochemistry Immunoglobulin G Receptors, Phospholipase A2
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100007
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spelling	oai:scielo:S0034-988720210001000072021-05-09Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro UniversitarioFrías Oyarzún,AlondraSegura Hidalgo,PaulaToro Cabrera,LuisElgueta Segura,LeticiaTorres Díaz,RubénAlvo Abodovsky,Miriam Glomerulonephritis, Membranous Immunohistochemistry Immunoglobulin G Receptors, Phospholipase A2 Background: The discovery of the phospholipase A2 receptor antigen and its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis and follow-up of patients with membranous nephropathy (MN). Thus, some international guidelines recommend not performing renal biopsy in patients with positive serum anti-PLA2R Ab. Aim: To evaluate the prevalence of anti-PLA2R Ab in serum and renal tissue samples from Chilean patients with primary MN. Material and Methods: Twenty-eight patients aged 50 ± 14 years (20 males) with biopsy-proven primary MN plus a negative workup for secondary causes were included. Measurements of serum and renal histologic anti-PLA2R Ab were performed. The relationship between the findings of serum and tissue anti-PLA2R Ab was evaluated. Results: Fifteen patients (54 %) had anti-PLA2R Ab presence in serum and 19 patients (68%) had positive anti-PLA2R Ab in the renal biopsy. All patients with positive serum anti-PLA2R Ab had positive antibodies on immunohistochemistry. Conclusions: Serum anti-PLA2R Ab is potentially useful in the diagnosis of patients with suspected primary MN in Chilean population.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.1 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100007es10.4067/S0034-98872021000100007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Glomerulonephritis, Membranous Immunohistochemistry Immunoglobulin G Receptors, Phospholipase A2
spellingShingle	Glomerulonephritis, Membranous Immunohistochemistry Immunoglobulin G Receptors, Phospholipase A2 Frías Oyarzún,Alondra Segura Hidalgo,Paula Toro Cabrera,Luis Elgueta Segura,Leticia Torres Díaz,Rubén Alvo Abodovsky,Miriam Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario
description	Background: The discovery of the phospholipase A2 receptor antigen and its highly specific autoantibody (anti-PLA2R Ab) was useful for the diagnosis and follow-up of patients with membranous nephropathy (MN). Thus, some international guidelines recommend not performing renal biopsy in patients with positive serum anti-PLA2R Ab. Aim: To evaluate the prevalence of anti-PLA2R Ab in serum and renal tissue samples from Chilean patients with primary MN. Material and Methods: Twenty-eight patients aged 50 ± 14 years (20 males) with biopsy-proven primary MN plus a negative workup for secondary causes were included. Measurements of serum and renal histologic anti-PLA2R Ab were performed. The relationship between the findings of serum and tissue anti-PLA2R Ab was evaluated. Results: Fifteen patients (54 %) had anti-PLA2R Ab presence in serum and 19 patients (68%) had positive anti-PLA2R Ab in the renal biopsy. All patients with positive serum anti-PLA2R Ab had positive antibodies on immunohistochemistry. Conclusions: Serum anti-PLA2R Ab is potentially useful in the diagnosis of patients with suspected primary MN in Chilean population.
author	Frías Oyarzún,Alondra Segura Hidalgo,Paula Toro Cabrera,Luis Elgueta Segura,Leticia Torres Díaz,Rubén Alvo Abodovsky,Miriam
author_facet	Frías Oyarzún,Alondra Segura Hidalgo,Paula Toro Cabrera,Luis Elgueta Segura,Leticia Torres Díaz,Rubén Alvo Abodovsky,Miriam
author_sort	Frías Oyarzún,Alondra
title	Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario
title_short	Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario
title_full	Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario
title_fullStr	Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario
title_full_unstemmed	Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario
title_sort	prevalencia del anticuerpo anti receptor de fosfolipasa a2 sérico e histológico en pacientes con nefropatía membranosa en un centro universitario
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100007
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Prevalencia del anticuerpo anti receptor de fosfolipasa A2 sérico e histológico en pacientes con nefropatía membranosa en un Centro Universitario

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