Concordance between estimated glomerular filtration rate using equations and that measured using an imaging method

ABSTRACT Background: Guidelines recommend estimating glomerular filtration rate (GFR) using creatinine-based equations (CBE). Aim: To evaluate the agreement between GFR measured using radionuclide imaging and estimated using creatinine-based equations. Material and Methods: In 421 patients aged 5...

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Autores principales:	González G.,Camilo A., Durán Camero,Alejandro, Vargas,María Teresa, García,Paola K., Contreras,Kateir, Rodríguez,Patricia
Lenguaje:	English
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Glomerular Filtration Rate Kidney Function Tests Radionuclide Imaging Renal Insufficiency, Chronic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100013
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spelling	oai:scielo:S0034-988720210001000132021-05-09Concordance between estimated glomerular filtration rate using equations and that measured using an imaging methodGonzález G.,Camilo A.Durán Camero,AlejandroVargas,María TeresaGarcía,Paola K.Contreras,KateirRodríguez,Patricia Glomerular Filtration Rate Kidney Function Tests Radionuclide Imaging Renal Insufficiency, Chronic ABSTRACT Background: Guidelines recommend estimating glomerular filtration rate (GFR) using creatinine-based equations (CBE). Aim: To evaluate the agreement between GFR measured using radionuclide imaging and estimated using creatinine-based equations. Material and Methods: In 421 patients aged 54 ± 17 years (47% women) GFR was estimated using the MDRD-4, CKD-EPI and the body surface adjusted Cockroft Gault equation. GFR was also measured using a radionuclide imaging method with 99mTc-DTPA. The concordance between estimated and measured GFR was calculated using Lin's concordance coefficient and Bland and Altman plots. Results: Average GFR values obtained with CKD-EPI, MDRD-4, body surface adjusted Cockroft Gault equation and 99mTc-DTPA imaging were 75.9 ± 26.6, 76.3 ± 28.8, 77.1 ± 31.6 and 77.9 ± 28.4 ml/min/1.73 m2, respectively. There was no significant difference in means and 29% of participants had a GFR < 60 ml/min/1.73 m2 by CKD-EPI. The correlation was good between equations, but acceptable when compared with the 99mTc-DTPA imaging. The weighted kappa between CBEs was good, but low when comparing CBEs with measured GFR. The Lin's concordance coefficient between estimated and measured GFR was low. Conclusions: GFR measured by 99mTc-DTPA radionuclide imaging has a low correlation and poor concordance with estimations using CBE.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.1 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100013en10.4067/S0034-98872021000100013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Glomerular Filtration Rate Kidney Function Tests Radionuclide Imaging Renal Insufficiency, Chronic
spellingShingle	Glomerular Filtration Rate Kidney Function Tests Radionuclide Imaging Renal Insufficiency, Chronic González G.,Camilo A. Durán Camero,Alejandro Vargas,María Teresa García,Paola K. Contreras,Kateir Rodríguez,Patricia Concordance between estimated glomerular filtration rate using equations and that measured using an imaging method
description	ABSTRACT Background: Guidelines recommend estimating glomerular filtration rate (GFR) using creatinine-based equations (CBE). Aim: To evaluate the agreement between GFR measured using radionuclide imaging and estimated using creatinine-based equations. Material and Methods: In 421 patients aged 54 ± 17 years (47% women) GFR was estimated using the MDRD-4, CKD-EPI and the body surface adjusted Cockroft Gault equation. GFR was also measured using a radionuclide imaging method with 99mTc-DTPA. The concordance between estimated and measured GFR was calculated using Lin's concordance coefficient and Bland and Altman plots. Results: Average GFR values obtained with CKD-EPI, MDRD-4, body surface adjusted Cockroft Gault equation and 99mTc-DTPA imaging were 75.9 ± 26.6, 76.3 ± 28.8, 77.1 ± 31.6 and 77.9 ± 28.4 ml/min/1.73 m2, respectively. There was no significant difference in means and 29% of participants had a GFR < 60 ml/min/1.73 m2 by CKD-EPI. The correlation was good between equations, but acceptable when compared with the 99mTc-DTPA imaging. The weighted kappa between CBEs was good, but low when comparing CBEs with measured GFR. The Lin's concordance coefficient between estimated and measured GFR was low. Conclusions: GFR measured by 99mTc-DTPA radionuclide imaging has a low correlation and poor concordance with estimations using CBE.
author	González G.,Camilo A. Durán Camero,Alejandro Vargas,María Teresa García,Paola K. Contreras,Kateir Rodríguez,Patricia
author_facet	González G.,Camilo A. Durán Camero,Alejandro Vargas,María Teresa García,Paola K. Contreras,Kateir Rodríguez,Patricia
author_sort	González G.,Camilo A.
title	Concordance between estimated glomerular filtration rate using equations and that measured using an imaging method
title_short	Concordance between estimated glomerular filtration rate using equations and that measured using an imaging method
title_full	Concordance between estimated glomerular filtration rate using equations and that measured using an imaging method
title_fullStr	Concordance between estimated glomerular filtration rate using equations and that measured using an imaging method
title_full_unstemmed	Concordance between estimated glomerular filtration rate using equations and that measured using an imaging method
title_sort	concordance between estimated glomerular filtration rate using equations and that measured using an imaging method
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100013
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Concordance between estimated glomerular filtration rate using equations and that measured using an imaging method

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