Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular

Glomerular filtration rate (GFR) is routinely estimated using endogenous biomarkers due to the complexity of direct measurement methods. Cystatin C is a protease inhibitor produced in all nucleated cells. It is freely filtered and then catabolized by renal tubular cells. Therefore, plasma concentrat...

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Autores principales:	Huidobro E.,Juan Pablo, Guzmán,Ana María, Tagle,Rodrigo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Cystatin C Glomerular Filtration Rate Kidney Function Tests
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100098
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spelling	oai:scielo:S0034-988720210001000982021-05-09Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerularHuidobro E.,Juan PabloGuzmán,Ana MaríaTagle,Rodrigo Cystatin C Glomerular Filtration Rate Kidney Function Tests Glomerular filtration rate (GFR) is routinely estimated using endogenous biomarkers due to the complexity of direct measurement methods. Cystatin C is a protease inhibitor produced in all nucleated cells. It is freely filtered and then catabolized by renal tubular cells. Therefore, plasma concentration of cystatin C depends primarily on GFR. Serum cystatin C is less affected by muscle mass, diet, race, gender and age than creatinine. In the general population, equations to estimate GFR based on cystatin C do not have a better performance than those based on creatinine. However, formulas that combine creatinine and cystatin C are more accurate and precise. Estimation of GFR based on cystatin C could be useful in populations in which creatinine value may be biased, such as people with extremely low or high muscle mass, cirrhosis and chronic cardiorenal syndrome. Due to its higher cost in comparison to creatinine, we recommend measuring cystatin C on these clinical situations and when a more accurate estimation of GFR is required.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.1 20212021-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100098es10.4067/S0034-98872021000100098
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Cystatin C Glomerular Filtration Rate Kidney Function Tests
spellingShingle	Cystatin C Glomerular Filtration Rate Kidney Function Tests Huidobro E.,Juan Pablo Guzmán,Ana María Tagle,Rodrigo Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular
description	Glomerular filtration rate (GFR) is routinely estimated using endogenous biomarkers due to the complexity of direct measurement methods. Cystatin C is a protease inhibitor produced in all nucleated cells. It is freely filtered and then catabolized by renal tubular cells. Therefore, plasma concentration of cystatin C depends primarily on GFR. Serum cystatin C is less affected by muscle mass, diet, race, gender and age than creatinine. In the general population, equations to estimate GFR based on cystatin C do not have a better performance than those based on creatinine. However, formulas that combine creatinine and cystatin C are more accurate and precise. Estimation of GFR based on cystatin C could be useful in populations in which creatinine value may be biased, such as people with extremely low or high muscle mass, cirrhosis and chronic cardiorenal syndrome. Due to its higher cost in comparison to creatinine, we recommend measuring cystatin C on these clinical situations and when a more accurate estimation of GFR is required.
author	Huidobro E.,Juan Pablo Guzmán,Ana María Tagle,Rodrigo
author_facet	Huidobro E.,Juan Pablo Guzmán,Ana María Tagle,Rodrigo
author_sort	Huidobro E.,Juan Pablo
title	Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular
title_short	Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular
title_full	Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular
title_fullStr	Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular
title_full_unstemmed	Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular
title_sort	uso de la cistatina c como biomarcador para estimar la tasa de filtración glomerular
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000100098
work_keys_str_mv	AT huidobroejuanpablo usodelacistatinaccomobiomarcadorparaestimarlatasadefiltracionglomerular AT guzmananamaria usodelacistatinaccomobiomarcadorparaestimarlatasadefiltracionglomerular AT taglerodrigo usodelacistatinaccomobiomarcadorparaestimarlatasadefiltracionglomerular
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Uso de la cistatina C como biomarcador para estimar la tasa de filtración glomerular

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