Trasplante pulmonar ex vivo . Primera experiencia en Chile y Latinoamérica

Background: The number of patients waiting for a lung transplant worldwide greatly exceeds the number of available donors. Ex vivo lung perfusion is a useful tool that allows marginal donor lungs to be evaluated and reconditioned for a successful lung transplantation. Aim: To describe the first Ch...

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Autores principales:	Undurraga M.,Felipe, Vega S.,Javier, Fajardo J.,Christian, Díaz G.,Rodrigo, Lazo P.,David, Rodríguez G.,Huascar, Villalabeitia R.,Eli, Sepúlveda V.,Edgardo, Rufs B.,Jorge, Dreyse D.,Jorge, Alarcón O.,Felipe, Valenzuela S.,Josefa, Seguel G.,Natalia, Castillo R.,Roberto, Arrau P.,Lorena, Calabrán R.,Lorena, Rodríguez D.,Patricio, Yeung,Jonathan C.
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Latin America Lung Lung Transplantation Perfusion
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200171
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spelling	oai:scielo:S0034-988720210002001712021-06-25Trasplante pulmonar ex vivo . Primera experiencia en Chile y LatinoaméricaUndurraga M.,FelipeVega S.,JavierFajardo J.,ChristianDíaz G.,RodrigoLazo P.,DavidRodríguez G.,HuascarVillalabeitia R.,EliSepúlveda V.,EdgardoRufs B.,JorgeDreyse D.,JorgeAlarcón O.,FelipeValenzuela S.,JosefaSeguel G.,NataliaCastillo R.,RobertoArrau P.,LorenaCalabrán R.,LorenaRodríguez D.,PatricioYeung,Jonathan C. Latin America Lung Lung Transplantation Perfusion Background: The number of patients waiting for a lung transplant worldwide greatly exceeds the number of available donors. Ex vivo lung perfusion is a useful tool that allows marginal donor lungs to be evaluated and reconditioned for a successful lung transplantation. Aim: To describe the first Chilean and Latin American experience in ex vivo lung perfusion for marginal donor lungs before transplantation. Material and Methods: Descriptive analysis of all ex vivo lung perfusion conducted for marginal donor lungs at a private clinic, from April 2019 to October 2020. High risk donor lungs and rejected lungs from other transplantation centers were included. The “Toronto Protocol” was used for ex vivo lung perfusion. Donor lung characteristics and recipient outcomes were studied. Results: During the study period, five ex vivo lung perfusions were performed. All lungs were reconditioned and transplanted. No complications were associated. There were no primary graft dysfunctions and only one chronic allograft dysfunction. There was no mortality during the first year. The median arterial oxygen partial pressure/fractional inspired oxygen ratio increased from 266 mm Hg in the donor lung to 419 after 3 hours of ex vivo lung perfusion (p = 0.043). Conclusions: ex vivo lung perfusion is a safe and useful tool that allows marginal donor lungs to be reconditioned and successfully transplanted.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.2 20212021-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200171es10.4067/s0034-98872021000200171
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Latin America Lung Lung Transplantation Perfusion
spellingShingle	Latin America Lung Lung Transplantation Perfusion Undurraga M.,Felipe Vega S.,Javier Fajardo J.,Christian Díaz G.,Rodrigo Lazo P.,David Rodríguez G.,Huascar Villalabeitia R.,Eli Sepúlveda V.,Edgardo Rufs B.,Jorge Dreyse D.,Jorge Alarcón O.,Felipe Valenzuela S.,Josefa Seguel G.,Natalia Castillo R.,Roberto Arrau P.,Lorena Calabrán R.,Lorena Rodríguez D.,Patricio Yeung,Jonathan C. Trasplante pulmonar ex vivo . Primera experiencia en Chile y Latinoamérica
description	Background: The number of patients waiting for a lung transplant worldwide greatly exceeds the number of available donors. Ex vivo lung perfusion is a useful tool that allows marginal donor lungs to be evaluated and reconditioned for a successful lung transplantation. Aim: To describe the first Chilean and Latin American experience in ex vivo lung perfusion for marginal donor lungs before transplantation. Material and Methods: Descriptive analysis of all ex vivo lung perfusion conducted for marginal donor lungs at a private clinic, from April 2019 to October 2020. High risk donor lungs and rejected lungs from other transplantation centers were included. The “Toronto Protocol” was used for ex vivo lung perfusion. Donor lung characteristics and recipient outcomes were studied. Results: During the study period, five ex vivo lung perfusions were performed. All lungs were reconditioned and transplanted. No complications were associated. There were no primary graft dysfunctions and only one chronic allograft dysfunction. There was no mortality during the first year. The median arterial oxygen partial pressure/fractional inspired oxygen ratio increased from 266 mm Hg in the donor lung to 419 after 3 hours of ex vivo lung perfusion (p = 0.043). Conclusions: ex vivo lung perfusion is a safe and useful tool that allows marginal donor lungs to be reconditioned and successfully transplanted.
author	Undurraga M.,Felipe Vega S.,Javier Fajardo J.,Christian Díaz G.,Rodrigo Lazo P.,David Rodríguez G.,Huascar Villalabeitia R.,Eli Sepúlveda V.,Edgardo Rufs B.,Jorge Dreyse D.,Jorge Alarcón O.,Felipe Valenzuela S.,Josefa Seguel G.,Natalia Castillo R.,Roberto Arrau P.,Lorena Calabrán R.,Lorena Rodríguez D.,Patricio Yeung,Jonathan C.
author_facet	Undurraga M.,Felipe Vega S.,Javier Fajardo J.,Christian Díaz G.,Rodrigo Lazo P.,David Rodríguez G.,Huascar Villalabeitia R.,Eli Sepúlveda V.,Edgardo Rufs B.,Jorge Dreyse D.,Jorge Alarcón O.,Felipe Valenzuela S.,Josefa Seguel G.,Natalia Castillo R.,Roberto Arrau P.,Lorena Calabrán R.,Lorena Rodríguez D.,Patricio Yeung,Jonathan C.
author_sort	Undurraga M.,Felipe
title	Trasplante pulmonar ex vivo . Primera experiencia en Chile y Latinoamérica
title_short	Trasplante pulmonar ex vivo . Primera experiencia en Chile y Latinoamérica
title_full	Trasplante pulmonar ex vivo . Primera experiencia en Chile y Latinoamérica
title_fullStr	Trasplante pulmonar ex vivo . Primera experiencia en Chile y Latinoamérica
title_full_unstemmed	Trasplante pulmonar ex vivo . Primera experiencia en Chile y Latinoamérica
title_sort	trasplante pulmonar ex vivo . primera experiencia en chile y latinoamérica
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200171
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Trasplante pulmonar ex vivo . Primera experiencia en Chile y Latinoamérica

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