¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?

Background: Glomerular filtration rate (GFR) estimation in older adults using a creatinine clearance/24-hour (CrCl) or an equation based on serum creatinine, are often considered equivalent by clinicians. Aim: To compare GFR estimated (eGFR) with the available equations and measured CrCl in patien...

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Autores principales:	Vega,Jorge, Huidobro E.,Juan Pablo, Sepúlveda,Rodrigo Andrés
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Creatinine Glomerular Filtration Rate Kidney Function Tests Renal Insufficiency, Chronic
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200187
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spelling	oai:scielo:S0034-988720210002001872021-06-25¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?Vega,JorgeHuidobro E.,Juan PabloSepúlveda,Rodrigo Andrés Creatinine Glomerular Filtration Rate Kidney Function Tests Renal Insufficiency, Chronic Background: Glomerular filtration rate (GFR) estimation in older adults using a creatinine clearance/24-hour (CrCl) or an equation based on serum creatinine, are often considered equivalent by clinicians. Aim: To compare GFR estimated (eGFR) with the available equations and measured CrCl in patients ≥ 70 years. A secondary aim was to know the differences in chronic kidney disease (CKD) classification, when using the different eGFR formulas. Patients and Methods: In 144 patients aged 77 ± 5 years (58% men), CrCl was measured and GFR was estimated using MDRD, CKD-EPI, BIS-1 and FAS formulas. The eGFR and the stage of CKD were compared according to the different equations used. Results: GFR estimated by MDRD and CKD-EPI equations was 7.8 and 8.4 mL/min/1.73 m2 lower than 24-hour ClCr, respectively. This difference was even greater using the BIS-1 and FAS equations. Twenty-four-hour CrCl classified 47.2% of the patients in a category of renal function > 60 mL/min/1.73 m2, while MDRD and CKD-EPI equations classified just over a third, and BIS-1 and FAS formulas around 20% of the patients. Conclusions: The practice of considering equivalent the GFR estimation using the creatinine-based equations with measured creatinine clearance in older adults should be reconsidered, because their results differ markedly.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.2 20212021-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200187es10.4067/s0034-98872021000200187
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Creatinine Glomerular Filtration Rate Kidney Function Tests Renal Insufficiency, Chronic
spellingShingle	Creatinine Glomerular Filtration Rate Kidney Function Tests Renal Insufficiency, Chronic Vega,Jorge Huidobro E.,Juan Pablo Sepúlveda,Rodrigo Andrés ¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?
description	Background: Glomerular filtration rate (GFR) estimation in older adults using a creatinine clearance/24-hour (CrCl) or an equation based on serum creatinine, are often considered equivalent by clinicians. Aim: To compare GFR estimated (eGFR) with the available equations and measured CrCl in patients ≥ 70 years. A secondary aim was to know the differences in chronic kidney disease (CKD) classification, when using the different eGFR formulas. Patients and Methods: In 144 patients aged 77 ± 5 years (58% men), CrCl was measured and GFR was estimated using MDRD, CKD-EPI, BIS-1 and FAS formulas. The eGFR and the stage of CKD were compared according to the different equations used. Results: GFR estimated by MDRD and CKD-EPI equations was 7.8 and 8.4 mL/min/1.73 m2 lower than 24-hour ClCr, respectively. This difference was even greater using the BIS-1 and FAS equations. Twenty-four-hour CrCl classified 47.2% of the patients in a category of renal function > 60 mL/min/1.73 m2, while MDRD and CKD-EPI equations classified just over a third, and BIS-1 and FAS formulas around 20% of the patients. Conclusions: The practice of considering equivalent the GFR estimation using the creatinine-based equations with measured creatinine clearance in older adults should be reconsidered, because their results differ markedly.
author	Vega,Jorge Huidobro E.,Juan Pablo Sepúlveda,Rodrigo Andrés
author_facet	Vega,Jorge Huidobro E.,Juan Pablo Sepúlveda,Rodrigo Andrés
author_sort	Vega,Jorge
title	¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?
title_short	¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?
title_full	¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?
title_fullStr	¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?
title_full_unstemmed	¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?
title_sort	¿son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200187
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¿Son equivalentes los diferentes métodos para estimar la función renal en los adultos mayores?

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