Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam

Background: Benzodiazepines are used for perioperative conscious sedation. However, its use may be associated with paradoxical reactions. The known risk factors for these reactions are age, alcohol and drug abuse and psychiatric disorders. Aim: To assess the incidence and impact of risk factors of...

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Autores principales:	Estefó,Magdalena, Ojeda,Dagoberto, Cisternas,Patricia, Arraño,Nicolás, Zanetta,Hugo
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Benzodiazepines Conscious Sedation Midazolam Risk Factors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200237
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spelling	oai:scielo:S0034-988720210002002372021-06-25Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolamEstefó,MagdalenaOjeda,DagobertoCisternas,PatriciaArraño,NicolásZanetta,Hugo Benzodiazepines Conscious Sedation Midazolam Risk Factors Background: Benzodiazepines are used for perioperative conscious sedation. However, its use may be associated with paradoxical reactions. The known risk factors for these reactions are age, alcohol and drug abuse and psychiatric disorders. Aim: To assess the incidence and impact of risk factors of paradoxical reactions to midazolam. Material and Methods: Cross sectional study of 218 patients aged 50 ± 16 years (51% women) scheduled for elective surgical procedures under regional anesthesia and midazolam sedation. The paradoxical reactions were classified according to their severity in three categories. Results: The incidence of paradoxical reactions to midazolam was 8.3% (95% confidence interval (CI) 5.0-12.7). All were mild and only 28% of the affected patients required pharmacological treatment, none of them flumazenil. A multivariable logistic regression model showed that the variables independently associated with a paradoxical reaction to midazolam were the use of psychoactive medications (Odds Ratio (OR) = 3.4 [1.1-11], p = 0.04, and the dose of midazolam (OR 1.35 [1.03-1.78], p = 0.03. Conclusions: The incidence of paradoxical reactions to midazolam was 8,3% and all were mild. Their risk factors are the use of psychoactive medications and the use of higher doses of midazolam.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.2 20212021-02-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200237es10.4067/s0034-98872021000200237
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Benzodiazepines Conscious Sedation Midazolam Risk Factors
spellingShingle	Benzodiazepines Conscious Sedation Midazolam Risk Factors Estefó,Magdalena Ojeda,Dagoberto Cisternas,Patricia Arraño,Nicolás Zanetta,Hugo Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam
description	Background: Benzodiazepines are used for perioperative conscious sedation. However, its use may be associated with paradoxical reactions. The known risk factors for these reactions are age, alcohol and drug abuse and psychiatric disorders. Aim: To assess the incidence and impact of risk factors of paradoxical reactions to midazolam. Material and Methods: Cross sectional study of 218 patients aged 50 ± 16 years (51% women) scheduled for elective surgical procedures under regional anesthesia and midazolam sedation. The paradoxical reactions were classified according to their severity in three categories. Results: The incidence of paradoxical reactions to midazolam was 8.3% (95% confidence interval (CI) 5.0-12.7). All were mild and only 28% of the affected patients required pharmacological treatment, none of them flumazenil. A multivariable logistic regression model showed that the variables independently associated with a paradoxical reaction to midazolam were the use of psychoactive medications (Odds Ratio (OR) = 3.4 [1.1-11], p = 0.04, and the dose of midazolam (OR 1.35 [1.03-1.78], p = 0.03. Conclusions: The incidence of paradoxical reactions to midazolam was 8,3% and all were mild. Their risk factors are the use of psychoactive medications and the use of higher doses of midazolam.
author	Estefó,Magdalena Ojeda,Dagoberto Cisternas,Patricia Arraño,Nicolás Zanetta,Hugo
author_facet	Estefó,Magdalena Ojeda,Dagoberto Cisternas,Patricia Arraño,Nicolás Zanetta,Hugo
author_sort	Estefó,Magdalena
title	Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam
title_short	Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam
title_full	Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam
title_fullStr	Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam
title_full_unstemmed	Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam
title_sort	factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000200237
work_keys_str_mv	AT estefomagdalena factoresderiesgodereaccionparadojicaasociadosasedacionendovenosaconmidazolam AT ojedadagoberto factoresderiesgodereaccionparadojicaasociadosasedacionendovenosaconmidazolam AT cisternaspatricia factoresderiesgodereaccionparadojicaasociadosasedacionendovenosaconmidazolam AT arranonicolas factoresderiesgodereaccionparadojicaasociadosasedacionendovenosaconmidazolam AT zanettahugo factoresderiesgodereaccionparadojicaasociadosasedacionendovenosaconmidazolam
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Factores de riesgo de reacción paradójica asociados a sedación endovenosa con midazolam

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