Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico

Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of hepatic pathologies ranging from simple steatosis (SS) to hepatocellular carcinoma. Intestinal microbiota (IM) is composed of trillions of microorganisms existing in the gut. It has 150 times more genes than the host. Changes i...

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Autores principales:	Tumani,María Fernanda, Tapia,Gladys, Aguirre,Carolina, Obregón,Ana María, Pettinelli,Paulina
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Dysbiosis Gastrointestinal Microbiome Non-alcoholic Fatty Liver Disease
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000400570
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spelling	oai:scielo:S0034-988720210004005702021-08-26Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólicoTumani,María FernandaTapia,GladysAguirre,CarolinaObregón,Ana MaríaPettinelli,Paulina Dysbiosis Gastrointestinal Microbiome Non-alcoholic Fatty Liver Disease Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of hepatic pathologies ranging from simple steatosis (SS) to hepatocellular carcinoma. Intestinal microbiota (IM) is composed of trillions of microorganisms existing in the gut. It has 150 times more genes than the host. Changes in the composition and function of the IM are associated with different diseases, including NAFLD. In this condition, IM could have a pathogenic role through different mechanisms such as energy salvaging from food, an inflammatory stimulus, a modulation of the innate immune system, regulation of bile acid turnover, alteration of choline metabolism and increasing endogenous ethanol levels. This review is an update on the role of the intestinal microbiota in NAFLD and the possible mechanisms involved.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.4 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000400570es10.4067/s0034-98872021000400570
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Dysbiosis Gastrointestinal Microbiome Non-alcoholic Fatty Liver Disease
spellingShingle	Dysbiosis Gastrointestinal Microbiome Non-alcoholic Fatty Liver Disease Tumani,María Fernanda Tapia,Gladys Aguirre,Carolina Obregón,Ana María Pettinelli,Paulina Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
description	Non-alcoholic fatty liver disease (NAFLD) encompasses a wide spectrum of hepatic pathologies ranging from simple steatosis (SS) to hepatocellular carcinoma. Intestinal microbiota (IM) is composed of trillions of microorganisms existing in the gut. It has 150 times more genes than the host. Changes in the composition and function of the IM are associated with different diseases, including NAFLD. In this condition, IM could have a pathogenic role through different mechanisms such as energy salvaging from food, an inflammatory stimulus, a modulation of the innate immune system, regulation of bile acid turnover, alteration of choline metabolism and increasing endogenous ethanol levels. This review is an update on the role of the intestinal microbiota in NAFLD and the possible mechanisms involved.
author	Tumani,María Fernanda Tapia,Gladys Aguirre,Carolina Obregón,Ana María Pettinelli,Paulina
author_facet	Tumani,María Fernanda Tapia,Gladys Aguirre,Carolina Obregón,Ana María Pettinelli,Paulina
author_sort	Tumani,María Fernanda
title	Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
title_short	Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
title_full	Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
title_fullStr	Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
title_full_unstemmed	Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
title_sort	rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000400570
work_keys_str_mv	AT tumanimariafernanda roldelamicrobiotaintestinaleneldesarrollodelhigadograsonoalcoholico AT tapiagladys roldelamicrobiotaintestinaleneldesarrollodelhigadograsonoalcoholico AT aguirrecarolina roldelamicrobiotaintestinaleneldesarrollodelhigadograsonoalcoholico AT obregonanamaria roldelamicrobiotaintestinaleneldesarrollodelhigadograsonoalcoholico AT pettinellipaulina roldelamicrobiotaintestinaleneldesarrollodelhigadograsonoalcoholico
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Rol de la microbiota intestinal en el desarrollo del hígado graso no alcohólico

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