Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización

Screening programs for colorectal cancer (CRC) are standard in most developed countries because they reduce mortality and are cost-effective. Within them, colonoscopy allows to directly visualize the colon and remove neoplastic lesions. However, it is an expensive exam with low adherence in asymptom...

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Autores principales:	Wielandt,Ana María, Hurtado,Claudia, Moreno,Mauricio, Zárate,Alejandro, López-Köstner,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Colorectal Neoplasms Clinical Laboratory Techniques Early Detection of Cancer Immunological Test Occult Blood
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000400580
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spelling	oai:scielo:S0034-988720210004005802021-08-26Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualizaciónWielandt,Ana MaríaHurtado,ClaudiaMoreno,MauricioZárate,AlejandroLópez-Köstner,Francisco Colorectal Neoplasms Clinical Laboratory Techniques Early Detection of Cancer Immunological Test Occult Blood Screening programs for colorectal cancer (CRC) are standard in most developed countries because they reduce mortality and are cost-effective. Within them, colonoscopy allows to directly visualize the colon and remove neoplastic lesions. However, it is an expensive exam with low adherence in asymptomatic individuals. The fecal occult blood test (FOBT) is a low-cost and risk-free method for the user, which results in a high rate of adherence, explaining its use in most screening programs. This article analyzes the effectiveness of different fecal occult blood tests in screening programs. The main conclusions are that the sensitivity of the guaiac-based chemical test for the detection of colorectal cancer is lower than that observed with qualitative and quantitative immunological tests. Automated quantitative methods allow objective readings independent of the operator and the reaction reading time, necessary for the analysis of large numbers of samples. The participation rate with immunological FOBTs is higher than with chemical ones, which is why they are preferred by the different countries that have screening programs. The use of quantitative tests allows stratification of symptomatic and asymptomatic patients at higher risk, in the screening programs.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.4 20212021-04-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000400580es10.4067/s0034-98872021000400580
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Colorectal Neoplasms Clinical Laboratory Techniques Early Detection of Cancer Immunological Test Occult Blood
spellingShingle	Colorectal Neoplasms Clinical Laboratory Techniques Early Detection of Cancer Immunological Test Occult Blood Wielandt,Ana María Hurtado,Claudia Moreno,Mauricio Zárate,Alejandro López-Köstner,Francisco Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización
description	Screening programs for colorectal cancer (CRC) are standard in most developed countries because they reduce mortality and are cost-effective. Within them, colonoscopy allows to directly visualize the colon and remove neoplastic lesions. However, it is an expensive exam with low adherence in asymptomatic individuals. The fecal occult blood test (FOBT) is a low-cost and risk-free method for the user, which results in a high rate of adherence, explaining its use in most screening programs. This article analyzes the effectiveness of different fecal occult blood tests in screening programs. The main conclusions are that the sensitivity of the guaiac-based chemical test for the detection of colorectal cancer is lower than that observed with qualitative and quantitative immunological tests. Automated quantitative methods allow objective readings independent of the operator and the reaction reading time, necessary for the analysis of large numbers of samples. The participation rate with immunological FOBTs is higher than with chemical ones, which is why they are preferred by the different countries that have screening programs. The use of quantitative tests allows stratification of symptomatic and asymptomatic patients at higher risk, in the screening programs.
author	Wielandt,Ana María Hurtado,Claudia Moreno,Mauricio Zárate,Alejandro López-Köstner,Francisco
author_facet	Wielandt,Ana María Hurtado,Claudia Moreno,Mauricio Zárate,Alejandro López-Köstner,Francisco
author_sort	Wielandt,Ana María
title	Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización
title_short	Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización
title_full	Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización
title_fullStr	Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización
title_full_unstemmed	Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización
title_sort	test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000400580
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Test de sangre oculta en deposiciones para programas de cribado de cáncer colorrectal: actualización

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