Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales

Background: The crossed cerebro-cerebellar (CCC) activation facilitates the diagnosis of cortical language lateralization, but needs to be explored with language tasks suitable for patients with different age ranges, educational attainment and eventual presence of language deficits. Aim: To determ...

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Autores principales:	Méndez-Orellana,Carolina, Arraño-Carrasco,Leonardo, Cortés-Rivera,Bárbara, Sandoval-León,Karina, Lorenzoni-Santos,José, Villanueva-Garín,Pablo, Rojas-Valdivia,Ricardo, Méndez-Ortega,Teobaldo, Monsalve-Rosales,Jaime, Flores-Kruuse,Paulo, Carmona-Rammsy,Pablo, Rojas-Pinto,David, Reyes-Ponce,Álvaro, Mery-Muñoz,Francisco
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Brain Neoplasms Cerebellum Functional Laterality Language Magnetic Resonance Imaging
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000500689
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spelling	oai:scielo:S0034-988720210005006892021-11-03Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebralesMéndez-Orellana,CarolinaArraño-Carrasco,LeonardoCortés-Rivera,BárbaraSandoval-León,KarinaLorenzoni-Santos,JoséVillanueva-Garín,PabloRojas-Valdivia,RicardoMéndez-Ortega,TeobaldoMonsalve-Rosales,JaimeFlores-Kruuse,PauloCarmona-Rammsy,PabloRojas-Pinto,DavidReyes-Ponce,ÁlvaroMery-Muñoz,Francisco Brain Neoplasms Cerebellum Functional Laterality Language Magnetic Resonance Imaging Background: The crossed cerebro-cerebellar (CCC) activation facilitates the diagnosis of cortical language lateralization, but needs to be explored with language tasks suitable for patients with different age ranges, educational attainment and eventual presence of language deficits. Aim: To determine the effect of demographic variables in the performance of three language tasks in healthy volunteers and to determine the CCC activation of these tasks as a functional magnetic resonance imaging (fMRI) paradigm in brain tumor patients. Material and Methods: The behavioral performance (correct responses and reaction time) of three language tasks (verbal fluency, semantic and phonological decision tasks) was first examined in 76 healthy volunteers balanced by age and educational level. Later, these tasks were implemented as fMRI paradigms to explore CCC language activation of 20 patients with potential diagnosis of brain tumors. Results: The performance of the verbal fluency task was affected by age. The CCC language activation was reproducible with the semantic and phonological tasks. The combination of the tasks determined typical and atypical language lateralization in 60% and 40% of our patients, respectively. Conclusions: The verbal fluency task must be implemented with care as a clinical fMRI paradigm. Our results suggest that semantic and phonological tasks can be a good alternative for brain tumor patients with language deficits.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.5 20212021-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000500689es10.4067/s0034-98872021000500689
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Brain Neoplasms Cerebellum Functional Laterality Language Magnetic Resonance Imaging
spellingShingle	Brain Neoplasms Cerebellum Functional Laterality Language Magnetic Resonance Imaging Méndez-Orellana,Carolina Arraño-Carrasco,Leonardo Cortés-Rivera,Bárbara Sandoval-León,Karina Lorenzoni-Santos,José Villanueva-Garín,Pablo Rojas-Valdivia,Ricardo Méndez-Ortega,Teobaldo Monsalve-Rosales,Jaime Flores-Kruuse,Paulo Carmona-Rammsy,Pablo Rojas-Pinto,David Reyes-Ponce,Álvaro Mery-Muñoz,Francisco Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales
description	Background: The crossed cerebro-cerebellar (CCC) activation facilitates the diagnosis of cortical language lateralization, but needs to be explored with language tasks suitable for patients with different age ranges, educational attainment and eventual presence of language deficits. Aim: To determine the effect of demographic variables in the performance of three language tasks in healthy volunteers and to determine the CCC activation of these tasks as a functional magnetic resonance imaging (fMRI) paradigm in brain tumor patients. Material and Methods: The behavioral performance (correct responses and reaction time) of three language tasks (verbal fluency, semantic and phonological decision tasks) was first examined in 76 healthy volunteers balanced by age and educational level. Later, these tasks were implemented as fMRI paradigms to explore CCC language activation of 20 patients with potential diagnosis of brain tumors. Results: The performance of the verbal fluency task was affected by age. The CCC language activation was reproducible with the semantic and phonological tasks. The combination of the tasks determined typical and atypical language lateralization in 60% and 40% of our patients, respectively. Conclusions: The verbal fluency task must be implemented with care as a clinical fMRI paradigm. Our results suggest that semantic and phonological tasks can be a good alternative for brain tumor patients with language deficits.
author	Méndez-Orellana,Carolina Arraño-Carrasco,Leonardo Cortés-Rivera,Bárbara Sandoval-León,Karina Lorenzoni-Santos,José Villanueva-Garín,Pablo Rojas-Valdivia,Ricardo Méndez-Ortega,Teobaldo Monsalve-Rosales,Jaime Flores-Kruuse,Paulo Carmona-Rammsy,Pablo Rojas-Pinto,David Reyes-Ponce,Álvaro Mery-Muñoz,Francisco
author_facet	Méndez-Orellana,Carolina Arraño-Carrasco,Leonardo Cortés-Rivera,Bárbara Sandoval-León,Karina Lorenzoni-Santos,José Villanueva-Garín,Pablo Rojas-Valdivia,Ricardo Méndez-Ortega,Teobaldo Monsalve-Rosales,Jaime Flores-Kruuse,Paulo Carmona-Rammsy,Pablo Rojas-Pinto,David Reyes-Ponce,Álvaro Mery-Muñoz,Francisco
author_sort	Méndez-Orellana,Carolina
title	Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales
title_short	Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales
title_full	Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales
title_fullStr	Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales
title_full_unstemmed	Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales
title_sort	evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000500689
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Evaluación de la actividad cerebro-cerebelar cruzada para determinar la lateralidad del lenguaje en pacientes con tumores cerebrales

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