Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?

Monoclonal gammopathies of uncertain significance (MGUS) correspond to pre-malignant hematological disorders characterized by the production of a monoclonal protein and infiltration of less than 10% of the bone marrow by plasma cells. Its importance lies in the risk of progression to malignant disor...

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Autores principales:	Meza-Romero,Rodrigo, Andino,Romina, Rojas,Patricio, Vargas,Sebastián, Jerez,Joaquín
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2021
Materias:	Monoclonal Gammopathy of Undetermined Significance Paraproteinemias Skin Diseases
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000500747
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spelling	oai:scielo:S0034-988720210005007472021-11-03Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?Meza-Romero,RodrigoAndino,RominaRojas,PatricioVargas,SebastiánJerez,Joaquín Monoclonal Gammopathy of Undetermined Significance Paraproteinemias Skin Diseases Monoclonal gammopathies of uncertain significance (MGUS) correspond to pre-malignant hematological disorders characterized by the production of a monoclonal protein and infiltration of less than 10% of the bone marrow by plasma cells. Its importance lies in the risk of progression to malignant disorders and in the association with different renal, neurological and skin manifestations. There are pathophysiological mechanisms that support a causal relationship between monoclonal gammopathies (MGs) and different skin diseases, such as type I cryoglobulinemia (CG), primary systemic amyloidosis (PSA) or necrobiotic xanthogranuloma (NXG). However, there is a group of skin diseases associated with MGs whose pathogenesis has not been elucidated. In this context, the role of the dermatologist is crucial in the suspicion of different haematological disorders based on skin manifestations and in the multidisciplinary treatment of these patients. In this article, we carry out an exhaustive review of the literature published in this area and propose a screening algorithm for MGs in patients with specific skin diseases.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.149 n.5 20212021-05-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000500747es10.4067/s0034-98872021000500747
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Monoclonal Gammopathy of Undetermined Significance Paraproteinemias Skin Diseases
spellingShingle	Monoclonal Gammopathy of Undetermined Significance Paraproteinemias Skin Diseases Meza-Romero,Rodrigo Andino,Romina Rojas,Patricio Vargas,Sebastián Jerez,Joaquín Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?
description	Monoclonal gammopathies of uncertain significance (MGUS) correspond to pre-malignant hematological disorders characterized by the production of a monoclonal protein and infiltration of less than 10% of the bone marrow by plasma cells. Its importance lies in the risk of progression to malignant disorders and in the association with different renal, neurological and skin manifestations. There are pathophysiological mechanisms that support a causal relationship between monoclonal gammopathies (MGs) and different skin diseases, such as type I cryoglobulinemia (CG), primary systemic amyloidosis (PSA) or necrobiotic xanthogranuloma (NXG). However, there is a group of skin diseases associated with MGs whose pathogenesis has not been elucidated. In this context, the role of the dermatologist is crucial in the suspicion of different haematological disorders based on skin manifestations and in the multidisciplinary treatment of these patients. In this article, we carry out an exhaustive review of the literature published in this area and propose a screening algorithm for MGs in patients with specific skin diseases.
author	Meza-Romero,Rodrigo Andino,Romina Rojas,Patricio Vargas,Sebastián Jerez,Joaquín
author_facet	Meza-Romero,Rodrigo Andino,Romina Rojas,Patricio Vargas,Sebastián Jerez,Joaquín
author_sort	Meza-Romero,Rodrigo
title	Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?
title_short	Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?
title_full	Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?
title_fullStr	Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?
title_full_unstemmed	Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?
title_sort	patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?
publisher	Sociedad Médica de Santiago
publishDate	2021
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872021000500747
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Patologías cutáneas asociadas a gammapatías monoclonales: ¿qué sabemos hasta ahora?

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