Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes

Secretion of LH is inhibited by opioid peptides during the prepubertal period in ewe lambs. The chronic blockade of opioid receptors with a long acting opioid receptor antagonist might accelerate the increase of LH secretion observed before the initiation of puberty. The objective of the present stu...

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Autores principales:	RECABARREN,S.E., ALBORNOZ,M.V., ESPINOZA,M., LOBOS,A.
Lenguaje:	nd
Publicado:	Facultad de Ciencias Veterinarias, Universidad Austral de Chile 1997
Materias:	borregas naltrexona hormona luteinizante
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X1997000100006
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spelling	oai:scielo:S0301-732X19970001000061999-05-24Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberesRECABARREN,S.E.ALBORNOZ,M.V.ESPINOZA,M.LOBOS,A. borregas naltrexona hormona luteinizante Secretion of LH is inhibited by opioid peptides during the prepubertal period in ewe lambs. The chronic blockade of opioid receptors with a long acting opioid receptor antagonist might accelerate the increase of LH secretion observed before the initiation of puberty. The objective of the present study was to explore the effect of naltrexone -a long acting opioid receptor antagonist- on the 24 h pattern of LH secretion and on the pulsatile LH secretion after 3 days of treatment. Ewe lambs (4 months old, 21 ± 1 kg, n=5) were given 1.5 mg naltrexone/kg body weight every 12 h for 3 days with a total of 7 doses. Pattern of LH secretion was assessed in plasma samples obtained at hourly intervals for 24 h which were analyzed with the COSINOR program; and with plasma samples obtained at 15 min intervals for six hours, which were analyzed with the PULSAR program before naltrexone treatment and before the treatment ended. Naltrexone did not modify the 24 h rhythm of LH secretion. On the other hand, the LH pulse frequency diminished from 7.8 ± 0.5 to 4.8 ± 0.4 pulses/6 h (p < 0.05). The mean pulse amplitude decreased from 0.83 &plusmn; 0.1 to 0.44 ± 0.07 (p < 0.05). Results suggest that naltrexone may be acting as an opioid agonist instead of antagonist in immature ewesinfo:eu-repo/semantics/openAccessFacultad de Ciencias Veterinarias, Universidad Austral de ChileArchivos de medicina veterinaria v.29 n.1 19971997-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X1997000100006nd10.4067/S0301-732X1997000100006
institution	Scielo Chile
collection	Scielo Chile
language	nd
topic	borregas naltrexona hormona luteinizante
spellingShingle	borregas naltrexona hormona luteinizante RECABARREN,S.E. ALBORNOZ,M.V. ESPINOZA,M. LOBOS,A. Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes
description	Secretion of LH is inhibited by opioid peptides during the prepubertal period in ewe lambs. The chronic blockade of opioid receptors with a long acting opioid receptor antagonist might accelerate the increase of LH secretion observed before the initiation of puberty. The objective of the present study was to explore the effect of naltrexone -a long acting opioid receptor antagonist- on the 24 h pattern of LH secretion and on the pulsatile LH secretion after 3 days of treatment. Ewe lambs (4 months old, 21 ± 1 kg, n=5) were given 1.5 mg naltrexone/kg body weight every 12 h for 3 days with a total of 7 doses. Pattern of LH secretion was assessed in plasma samples obtained at hourly intervals for 24 h which were analyzed with the COSINOR program; and with plasma samples obtained at 15 min intervals for six hours, which were analyzed with the PULSAR program before naltrexone treatment and before the treatment ended. Naltrexone did not modify the 24 h rhythm of LH secretion. On the other hand, the LH pulse frequency diminished from 7.8 ± 0.5 to 4.8 ± 0.4 pulses/6 h (p < 0.05). The mean pulse amplitude decreased from 0.83 &plusmn; 0.1 to 0.44 ± 0.07 (p < 0.05). Results suggest that naltrexone may be acting as an opioid agonist instead of antagonist in immature ewes
author	RECABARREN,S.E. ALBORNOZ,M.V. ESPINOZA,M. LOBOS,A.
author_facet	RECABARREN,S.E. ALBORNOZ,M.V. ESPINOZA,M. LOBOS,A.
author_sort	RECABARREN,S.E.
title	Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes
title_short	Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes
title_full	Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes
title_fullStr	Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes
title_full_unstemmed	Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes
title_sort	efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes
publisher	Facultad de Ciencias Veterinarias, Universidad Austral de Chile
publishDate	1997
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X1997000100006
work_keys_str_mv	AT recabarrense efectodelanaltrexonasobreelperfildesecreciondehormonaluteinizanteenovejasprepuberes AT albornozmv efectodelanaltrexonasobreelperfildesecreciondehormonaluteinizanteenovejasprepuberes AT espinozam efectodelanaltrexonasobreelperfildesecreciondehormonaluteinizanteenovejasprepuberes AT lobosa efectodelanaltrexonasobreelperfildesecreciondehormonaluteinizanteenovejasprepuberes
_version_	1718437762424635392

Efecto de la naltrexona sobre el perfil de secreción de hormona luteinizante en ovejas prepúberes

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