Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy

The development of a dose-dependent cardiomyopathy is the main limitation for the use of doxorubicin in chemotherapy protocols in both humans and animals. In this setting, the global myocardial function may be compromised resulting in signs of congestive heart failure. In this study, we investigated...

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Autores principales:	Sousa,MG, Paulino-Junior,D, Pascon,JPE, Pereira-Neto,GB, Carareto,R, Camacho,AA
Lenguaje:	English
Publicado:	Facultad de Ciencias Veterinarias, Universidad Austral de Chile 2014
Materias:	cardiotoxicity anthracycline cardiac dysfunction chemotherapy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2014000100009
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spelling	oai:scielo:S0301-732X20140001000092015-10-30Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathySousa,MGPaulino-Junior,DPascon,JPEPereira-Neto,GBCarareto,RCamacho,AA cardiotoxicity anthracycline cardiac dysfunction chemotherapy The development of a dose-dependent cardiomyopathy is the main limitation for the use of doxorubicin in chemotherapy protocols in both humans and animals. In this setting, the global myocardial function may be compromised resulting in signs of congestive heart failure. In this study, we investigated the ability of the Tei index of myocardial performance to identify myocardial dysfunction in healthy dogs receiving doxorubicin to a cumulative dose of 210 mg/m² over 147 days, comparing it with other standard echocardiographic indicators of systolic and diastolic function. Our results indicated that the Tei index, the isovolumic relaxation time, pre-ejection period and the pre-ejection period-to-left ventricular ejection time ratio were able to identify the cardiotoxic effects of doxorubicin on cardiac function when only 60 mg/m² had been administered, while the standard systolic and diastolic parameters, including left ventricular diameter at systole, ejection fraction, and fractional shortening needed at least 120 mg/mg² to deteriorate. We concluded that prolonged anthracycline therapy compromises both systolic and diastolic functions, which may be documented earlier by including the Tei index evaluation to the standard echocardiographic assessment of animals receiving doxorubicin.info:eu-repo/semantics/openAccessFacultad de Ciencias Veterinarias, Universidad Austral de ChileArchivos de medicina veterinaria v.46 n.1 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2014000100009en10.4067/S0301-732X2014000100009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	cardiotoxicity anthracycline cardiac dysfunction chemotherapy
spellingShingle	cardiotoxicity anthracycline cardiac dysfunction chemotherapy Sousa,MG Paulino-Junior,D Pascon,JPE Pereira-Neto,GB Carareto,R Camacho,AA Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy
description	The development of a dose-dependent cardiomyopathy is the main limitation for the use of doxorubicin in chemotherapy protocols in both humans and animals. In this setting, the global myocardial function may be compromised resulting in signs of congestive heart failure. In this study, we investigated the ability of the Tei index of myocardial performance to identify myocardial dysfunction in healthy dogs receiving doxorubicin to a cumulative dose of 210 mg/m² over 147 days, comparing it with other standard echocardiographic indicators of systolic and diastolic function. Our results indicated that the Tei index, the isovolumic relaxation time, pre-ejection period and the pre-ejection period-to-left ventricular ejection time ratio were able to identify the cardiotoxic effects of doxorubicin on cardiac function when only 60 mg/m² had been administered, while the standard systolic and diastolic parameters, including left ventricular diameter at systole, ejection fraction, and fractional shortening needed at least 120 mg/mg² to deteriorate. We concluded that prolonged anthracycline therapy compromises both systolic and diastolic functions, which may be documented earlier by including the Tei index evaluation to the standard echocardiographic assessment of animals receiving doxorubicin.
author	Sousa,MG Paulino-Junior,D Pascon,JPE Pereira-Neto,GB Carareto,R Camacho,AA
author_facet	Sousa,MG Paulino-Junior,D Pascon,JPE Pereira-Neto,GB Carareto,R Camacho,AA
author_sort	Sousa,MG
title	Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy
title_short	Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy
title_full	Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy
title_fullStr	Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy
title_full_unstemmed	Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy
title_sort	assesment of the tei index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy
publisher	Facultad de Ciencias Veterinarias, Universidad Austral de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2014000100009
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Assesment of the TEI index of myocardial performance in dogs with doxorubicin-induced cardiomiopathy

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