Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review

This systematic review aimed to assess the efficacy of sildenafil in the treatment of pulmonary hypertension (PH) in dogs and, when possible, to propose recommendations for or against its use. Electronic searches were carried out using six international databases. The inclusion criterion was in vivo...

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Autores principales:	Silva,AC, Oberlender,G, Mantovani,MM, Muzzi,RAL, Pereira,LJ, Zangeronimo,MG
Lenguaje:	English
Publicado:	Facultad de Ciencias Veterinarias, Universidad Austral de Chile 2014
Materias:	canine pulmonary disease therapy sildenafil
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2014000200014
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spelling	oai:scielo:S0301-732X20140002000142014-09-11Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic reviewSilva,ACOberlender,GMantovani,MMMuzzi,RALPereira,LJZangeronimo,MG canine pulmonary disease therapy sildenafil This systematic review aimed to assess the efficacy of sildenafil in the treatment of pulmonary hypertension (PH) in dogs and, when possible, to propose recommendations for or against its use. Electronic searches were carried out using six international databases. The inclusion criterion was in vivo clinical trials that assessed the efficacy of sildenafil in the treatment of naturally occurring PH. The scoring system was designed to take into account aspects such as the form of distribution and masking of experimental treatments, the number of animals, association with other drugs, diagnostic methods for PH, evaluations of the clinical response to treatment and adverse effects. A total of five papers were found. In general, the clinical condition and quality of life of the animals improved after sildenafil therapy, and the occurrence of adverse effects was uncommon. Echocardiographic findings provided evidence for changes in pulmonary arterial pressure which could be associated with alterations in physical activity and survival time. Still, the methodological quality of the studies was low, only one of them was a randomised, placebo-controlled and double-blind clinical trial. Furthermore, with modest evidence, this study allowed the recommendation that sildenafil is an important therapy which can play a positive therapeutic role in the treatment of canine PH. Additionally, prospective, randomised, blinded and controlled studies with a larger number of animals assessing physical activity and the adverse effects of sildenafil and other drugs in association are recommended to evaluate the efficacy of this drug in dogs.info:eu-repo/semantics/openAccessFacultad de Ciencias Veterinarias, Universidad Austral de ChileArchivos de medicina veterinaria v.46 n.2 20142014-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2014000200014en10.4067/S0301-732X2014000200014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	canine pulmonary disease therapy sildenafil
spellingShingle	canine pulmonary disease therapy sildenafil Silva,AC Oberlender,G Mantovani,MM Muzzi,RAL Pereira,LJ Zangeronimo,MG Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review
description	This systematic review aimed to assess the efficacy of sildenafil in the treatment of pulmonary hypertension (PH) in dogs and, when possible, to propose recommendations for or against its use. Electronic searches were carried out using six international databases. The inclusion criterion was in vivo clinical trials that assessed the efficacy of sildenafil in the treatment of naturally occurring PH. The scoring system was designed to take into account aspects such as the form of distribution and masking of experimental treatments, the number of animals, association with other drugs, diagnostic methods for PH, evaluations of the clinical response to treatment and adverse effects. A total of five papers were found. In general, the clinical condition and quality of life of the animals improved after sildenafil therapy, and the occurrence of adverse effects was uncommon. Echocardiographic findings provided evidence for changes in pulmonary arterial pressure which could be associated with alterations in physical activity and survival time. Still, the methodological quality of the studies was low, only one of them was a randomised, placebo-controlled and double-blind clinical trial. Furthermore, with modest evidence, this study allowed the recommendation that sildenafil is an important therapy which can play a positive therapeutic role in the treatment of canine PH. Additionally, prospective, randomised, blinded and controlled studies with a larger number of animals assessing physical activity and the adverse effects of sildenafil and other drugs in association are recommended to evaluate the efficacy of this drug in dogs.
author	Silva,AC Oberlender,G Mantovani,MM Muzzi,RAL Pereira,LJ Zangeronimo,MG
author_facet	Silva,AC Oberlender,G Mantovani,MM Muzzi,RAL Pereira,LJ Zangeronimo,MG
author_sort	Silva,AC
title	Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review
title_short	Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review
title_full	Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review
title_fullStr	Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review
title_full_unstemmed	Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review
title_sort	efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review
publisher	Facultad de Ciencias Veterinarias, Universidad Austral de Chile
publishDate	2014
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2014000200014
work_keys_str_mv	AT silvaac efficacyofsildenafiltherapyforpulmonaryhypertensionindogsasystematicreview AT oberlenderg efficacyofsildenafiltherapyforpulmonaryhypertensionindogsasystematicreview AT mantovanimm efficacyofsildenafiltherapyforpulmonaryhypertensionindogsasystematicreview AT muzziral efficacyofsildenafiltherapyforpulmonaryhypertensionindogsasystematicreview AT pereiralj efficacyofsildenafiltherapyforpulmonaryhypertensionindogsasystematicreview AT zangeronimomg efficacyofsildenafiltherapyforpulmonaryhypertensionindogsasystematicreview
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Efficacy of sildenafil therapy for pulmonary hypertension in dogs: a systematic review

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