The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature review

The PI3K/AKT/mTOR pathway is related to proliferation, protein synthesis, survival, angiogenesis, apoptosis, and cell motility. Genetic alterations in either activation of oncogenes or inactivation of tumor suppressor make it the second most altered pathway in neoplastic processes. The PI3K/AKT/mTOR...

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Autores principales:	Ferreira,MGPA, Reis Filho,NP, Pascoli,AL, Arosti,BM, Pazzini,JM, Huppes,RR, De Nardi,AB, Tinucci-Costa,M, Laufer-Amorim,R
Lenguaje:	English
Publicado:	Facultad de Ciencias Veterinarias, Universidad Austral de Chile 2016
Materias:	mast cell tumors osteosarcoma hemangiosarcoma mammary carninoma dog
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2016000200002
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spelling	oai:scielo:S0301-732X20160002000022016-11-03The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature reviewFerreira,MGPAReis Filho,NPPascoli,ALArosti,BMPazzini,JMHuppes,RRDe Nardi,ABTinucci-Costa,MLaufer-Amorim,R mast cell tumors osteosarcoma hemangiosarcoma mammary carninoma dog The PI3K/AKT/mTOR pathway is related to proliferation, protein synthesis, survival, angiogenesis, apoptosis, and cell motility. Genetic alterations in either activation of oncogenes or inactivation of tumor suppressor make it the second most altered pathway in neoplastic processes. The PI3K/AKT/mTOR pathway is currently considered an attractive target for the development of anti-tumor molecules. Specific inhibitors of this pathway are under development, and those already recognized are being tested in clinical trials, representing a promising approach for the treatment of cancer patients. It is believed that, as this pathway is involved in the development of many human cancers, its activation may also be related to the development of various canine neoplasms. Therefore, this review aims to describe the state-of-the-art knowledge about the PI3K/AKT/mTOR pathway and highlight some research performed with either canine tumors or cellular lines.info:eu-repo/semantics/openAccessFacultad de Ciencias Veterinarias, Universidad Austral de ChileArchivos de medicina veterinaria v.48 n.2 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2016000200002en10.4067/S0301-732X2016000200002
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	mast cell tumors osteosarcoma hemangiosarcoma mammary carninoma dog
spellingShingle	mast cell tumors osteosarcoma hemangiosarcoma mammary carninoma dog Ferreira,MGPA Reis Filho,NP Pascoli,AL Arosti,BM Pazzini,JM Huppes,RR De Nardi,AB Tinucci-Costa,M Laufer-Amorim,R The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature review
description	The PI3K/AKT/mTOR pathway is related to proliferation, protein synthesis, survival, angiogenesis, apoptosis, and cell motility. Genetic alterations in either activation of oncogenes or inactivation of tumor suppressor make it the second most altered pathway in neoplastic processes. The PI3K/AKT/mTOR pathway is currently considered an attractive target for the development of anti-tumor molecules. Specific inhibitors of this pathway are under development, and those already recognized are being tested in clinical trials, representing a promising approach for the treatment of cancer patients. It is believed that, as this pathway is involved in the development of many human cancers, its activation may also be related to the development of various canine neoplasms. Therefore, this review aims to describe the state-of-the-art knowledge about the PI3K/AKT/mTOR pathway and highlight some research performed with either canine tumors or cellular lines.
author	Ferreira,MGPA Reis Filho,NP Pascoli,AL Arosti,BM Pazzini,JM Huppes,RR De Nardi,AB Tinucci-Costa,M Laufer-Amorim,R
author_facet	Ferreira,MGPA Reis Filho,NP Pascoli,AL Arosti,BM Pazzini,JM Huppes,RR De Nardi,AB Tinucci-Costa,M Laufer-Amorim,R
author_sort	Ferreira,MGPA
title	The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature review
title_short	The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature review
title_full	The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature review
title_fullStr	The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature review
title_full_unstemmed	The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature review
title_sort	importance of the pi3k/akt/mtor signaling pathway in canine neoplasms: literature review
publisher	Facultad de Ciencias Veterinarias, Universidad Austral de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2016000200002
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The importance of the PI3K/AKT/mTOR signaling pathway in canine neoplasms: Literature review

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