Cardiac biomarkers in dogs with visceral leishmaniasis

Although only a few studies have focused on the cardiac alterations in Leishmania spp. infected dogs, myocardial inflammation ascribed to such parasite has been documented in some animals. In spite of the increasing popularity of cardiac biomarkers in veterinary medicine in recent years, it remains...

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Autores principales:	Silva,VBC, Sousa,MG, Araújo,CRA, Lima,ABG, Carareto,R
Lenguaje:	English
Publicado:	Facultad de Ciencias Veterinarias, Universidad Austral de Chile 2016
Materias:	parasitic disease myocarditis natriuretic peptides troponins
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2016000300004
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spelling	oai:scielo:S0301-732X20160003000042016-12-27Cardiac biomarkers in dogs with visceral leishmaniasisSilva,VBCSousa,MGAraújo,CRALima,ABGCarareto,R parasitic disease myocarditis natriuretic peptides troponins Although only a few studies have focused on the cardiac alterations in Leishmania spp. infected dogs, myocardial inflammation ascribed to such parasite has been documented in some animals. In spite of the increasing popularity of cardiac biomarkers in veterinary medicine in recent years, it remains unknown how most of these substances would perform in dogs with visceral leishmaniasis. In this study, we hypothesised that Leishmania spp. would damage cardiac myofibers resulting in increased circulating levels of cardiac specific markers in dogs. Therefore, biomarkers of myocyte injury and stress were investigated in 18 dogs with naturally-occurring visceral leishmaniasis presenting varying clinical signs, including completely asymptomatic animals. The median (min-max) concentrations of NT-proANP, NT-proBNP, cTnI, and CK-MB were 1138.0 (875-1175) pmol/L, 1160.0 (803-2034) fmol/L, 0.22 (0.15-0.51) ng/mL, and 116.7 (113-222) U/L, respectively. No differences were documented for the concentration of the natriuretic peptides and CK-MB in accordance with the severity of clinical signs, but for cTnI a significant difference was reported when comparing asymptomatic and symptomatic animals. Also, the compromise of renal tubular function seemed to interfere with the concentration of the natriuretic peptides and cTnI. In conclusion, all cardiac-specific biomarkers were elevated when compared to the normal range previously proposed for dogs. Measuring specific cardiac biomarkers has the potential to non-invasively document myocardial injuries attributable to visceral leishmaniasis.info:eu-repo/semantics/openAccessFacultad de Ciencias Veterinarias, Universidad Austral de ChileArchivos de medicina veterinaria v.48 n.3 20162016-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2016000300004en10.4067/S0301-732X2016000300004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	parasitic disease myocarditis natriuretic peptides troponins
spellingShingle	parasitic disease myocarditis natriuretic peptides troponins Silva,VBC Sousa,MG Araújo,CRA Lima,ABG Carareto,R Cardiac biomarkers in dogs with visceral leishmaniasis
description	Although only a few studies have focused on the cardiac alterations in Leishmania spp. infected dogs, myocardial inflammation ascribed to such parasite has been documented in some animals. In spite of the increasing popularity of cardiac biomarkers in veterinary medicine in recent years, it remains unknown how most of these substances would perform in dogs with visceral leishmaniasis. In this study, we hypothesised that Leishmania spp. would damage cardiac myofibers resulting in increased circulating levels of cardiac specific markers in dogs. Therefore, biomarkers of myocyte injury and stress were investigated in 18 dogs with naturally-occurring visceral leishmaniasis presenting varying clinical signs, including completely asymptomatic animals. The median (min-max) concentrations of NT-proANP, NT-proBNP, cTnI, and CK-MB were 1138.0 (875-1175) pmol/L, 1160.0 (803-2034) fmol/L, 0.22 (0.15-0.51) ng/mL, and 116.7 (113-222) U/L, respectively. No differences were documented for the concentration of the natriuretic peptides and CK-MB in accordance with the severity of clinical signs, but for cTnI a significant difference was reported when comparing asymptomatic and symptomatic animals. Also, the compromise of renal tubular function seemed to interfere with the concentration of the natriuretic peptides and cTnI. In conclusion, all cardiac-specific biomarkers were elevated when compared to the normal range previously proposed for dogs. Measuring specific cardiac biomarkers has the potential to non-invasively document myocardial injuries attributable to visceral leishmaniasis.
author	Silva,VBC Sousa,MG Araújo,CRA Lima,ABG Carareto,R
author_facet	Silva,VBC Sousa,MG Araújo,CRA Lima,ABG Carareto,R
author_sort	Silva,VBC
title	Cardiac biomarkers in dogs with visceral leishmaniasis
title_short	Cardiac biomarkers in dogs with visceral leishmaniasis
title_full	Cardiac biomarkers in dogs with visceral leishmaniasis
title_fullStr	Cardiac biomarkers in dogs with visceral leishmaniasis
title_full_unstemmed	Cardiac biomarkers in dogs with visceral leishmaniasis
title_sort	cardiac biomarkers in dogs with visceral leishmaniasis
publisher	Facultad de Ciencias Veterinarias, Universidad Austral de Chile
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0301-732X2016000300004
work_keys_str_mv	AT silvavbc cardiacbiomarkersindogswithvisceralleishmaniasis AT sousamg cardiacbiomarkersindogswithvisceralleishmaniasis AT araujocra cardiacbiomarkersindogswithvisceralleishmaniasis AT limaabg cardiacbiomarkersindogswithvisceralleishmaniasis AT cararetor cardiacbiomarkersindogswithvisceralleishmaniasis
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Cardiac biomarkers in dogs with visceral leishmaniasis

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