A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERS

Biological membranes are the initial targets of pollutants from the surrounding environment. Understanding the mechanisms controlling their interactions at the molecular level is of primary importance to interpret the results of bio-accumulation and toxic effects. Mercury is a major environmental co...

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Autores principales:	SUWALSKY,MARIO, UNGERER,BRIGITTE
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2000
Materias:	Mercuric chloride methylmercury cell membrane phospholipid bilayer
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442000000200019
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spelling	oai:scielo:S0366-164420000002000192000-08-25A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERSSUWALSKY,MARIOUNGERER,BRIGITTE Mercuric chloride methylmercury cell membrane phospholipid bilayer Biological membranes are the initial targets of pollutants from the surrounding environment. Understanding the mechanisms controlling their interactions at the molecular level is of primary importance to interpret the results of bio-accumulation and toxic effects. Mercury is a major environmental contaminant, which has been shown to cause increased morbidity and mortality in humans. In order to understand the molecular mechanism of mercury toxicity with cell membranes HgCl2 and CH3HgCl were made to interact with multilayers built up of dimyristoylphosphatidylcholine (DMPC) and dimyristoylhosphatidylethanolamine (DMPE), which represent classes of phospholipids located in the outer and inner monolayers of the human erythrocyte membrane, respectively. Results presented in this paper indicated that both mercuric compounds interacted with and perturbed the molecular structures of DMPC and DMPE. These studies were performed by X-ray diffraction methodsinfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaBoletín de la Sociedad Chilena de Química v.45 n.2 20002000-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442000000200019en10.4067/S0366-16442000000200019
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Mercuric chloride methylmercury cell membrane phospholipid bilayer
spellingShingle	Mercuric chloride methylmercury cell membrane phospholipid bilayer SUWALSKY,MARIO UNGERER,BRIGITTE A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERS
description	Biological membranes are the initial targets of pollutants from the surrounding environment. Understanding the mechanisms controlling their interactions at the molecular level is of primary importance to interpret the results of bio-accumulation and toxic effects. Mercury is a major environmental contaminant, which has been shown to cause increased morbidity and mortality in humans. In order to understand the molecular mechanism of mercury toxicity with cell membranes HgCl2 and CH3HgCl were made to interact with multilayers built up of dimyristoylphosphatidylcholine (DMPC) and dimyristoylhosphatidylethanolamine (DMPE), which represent classes of phospholipids located in the outer and inner monolayers of the human erythrocyte membrane, respectively. Results presented in this paper indicated that both mercuric compounds interacted with and perturbed the molecular structures of DMPC and DMPE. These studies were performed by X-ray diffraction methods
author	SUWALSKY,MARIO UNGERER,BRIGITTE
author_facet	SUWALSKY,MARIO UNGERER,BRIGITTE
author_sort	SUWALSKY,MARIO
title	A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERS
title_short	A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERS
title_full	A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERS
title_fullStr	A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERS
title_full_unstemmed	A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERS
title_sort	structural study on the interaction of mercuric chloride and methylmercury with phospholipid bilayers
publisher	Sociedad Chilena de Química
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442000000200019
work_keys_str_mv	AT suwalskymario astructuralstudyontheinteractionofmercuricchlorideandmethylmercurywithphospholipidbilayers AT ungererbrigitte astructuralstudyontheinteractionofmercuricchlorideandmethylmercurywithphospholipidbilayers AT suwalskymario structuralstudyontheinteractionofmercuricchlorideandmethylmercurywithphospholipidbilayers AT ungererbrigitte structuralstudyontheinteractionofmercuricchlorideandmethylmercurywithphospholipidbilayers
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A STRUCTURAL STUDY ON THE INTERACTION OF MERCURIC CHLORIDE AND METHYLMERCURY WITH PHOSPHOLIPID BILAYERS

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