AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY

In addition to azorellanol a new diterpenoid 7-deacetylazorellanol, has been isolated from the aerial parts of Laretia acaulis (Cav.) Gill et Hook (Umbelliferae). Its structure was based on spectroscopic comparison with azorellanol and chemical grounds. Azorellanol and 7-deacetylazorellanol showed m...

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Autores principales:	LOYOLA,LUIS A., BORQUEZ,JORGE, MORALES,GLAUCO, ARAYA,JORGE, GONZALEZ,JORGE, NEIRA,IVAN, SAGUA,HERNAN, SAN-MARTÍN,AURELIO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2001
Materias:	Laretia acaulis diterpenoids azorellanol 7-deacetylazorellanol Toxoplasma gondii
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442001000100003
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spelling	oai:scielo:S0366-164420010001000032001-05-30AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITYLOYOLA,LUIS A.BORQUEZ,JORGEMORALES,GLAUCOARAYA,JORGEGONZALEZ,JORGENEIRA,IVANSAGUA,HERNANSAN-MARTÍN,AURELIO Laretia acaulis diterpenoids azorellanol 7-deacetylazorellanol Toxoplasma gondii In addition to azorellanol a new diterpenoid 7-deacetylazorellanol, has been isolated from the aerial parts of Laretia acaulis (Cav.) Gill et Hook (Umbelliferae). Its structure was based on spectroscopic comparison with azorellanol and chemical grounds. Azorellanol and 7-deacetylazorellanol showed marked inhibitor activity against trophozoites of protozoan parasite Toxoplasma gondii. The 50 % inhibitory dose for azorellanol was calculated in 54 muM and for 7-deacetylazorellanol was 42 mM.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaBoletín de la Sociedad Chilena de Química v.46 n.1 20012001-03-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442001000100003en10.4067/S0366-16442001000100003
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Laretia acaulis diterpenoids azorellanol 7-deacetylazorellanol Toxoplasma gondii
spellingShingle	Laretia acaulis diterpenoids azorellanol 7-deacetylazorellanol Toxoplasma gondii LOYOLA,LUIS A. BORQUEZ,JORGE MORALES,GLAUCO ARAYA,JORGE GONZALEZ,JORGE NEIRA,IVAN SAGUA,HERNAN SAN-MARTÍN,AURELIO AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY
description	In addition to azorellanol a new diterpenoid 7-deacetylazorellanol, has been isolated from the aerial parts of Laretia acaulis (Cav.) Gill et Hook (Umbelliferae). Its structure was based on spectroscopic comparison with azorellanol and chemical grounds. Azorellanol and 7-deacetylazorellanol showed marked inhibitor activity against trophozoites of protozoan parasite Toxoplasma gondii. The 50 % inhibitory dose for azorellanol was calculated in 54 muM and for 7-deacetylazorellanol was 42 mM.
author	LOYOLA,LUIS A. BORQUEZ,JORGE MORALES,GLAUCO ARAYA,JORGE GONZALEZ,JORGE NEIRA,IVAN SAGUA,HERNAN SAN-MARTÍN,AURELIO
author_facet	LOYOLA,LUIS A. BORQUEZ,JORGE MORALES,GLAUCO ARAYA,JORGE GONZALEZ,JORGE NEIRA,IVAN SAGUA,HERNAN SAN-MARTÍN,AURELIO
author_sort	LOYOLA,LUIS A.
title	AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY
title_short	AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY
title_full	AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY
title_fullStr	AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY
title_full_unstemmed	AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY
title_sort	azorellane diterpenoids from laretia acaulis, and its toxoplasmacidal activity
publisher	Sociedad Chilena de Química
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442001000100003
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AZORELLANE DITERPENOIDS FROM LARETIA ACAULIS, AND ITS TOXOPLASMACIDAL ACTIVITY

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