CONFORMATIONAL DYNAMICS OF SUBSTITUTED N-ACETYL-N-PHENYLBENZYLAMINES. 1H-DNMR AND AM1-MO STUDY

Activation parameters for the rotation around the methylene-nitrogen single bond found in a series of four 2,2´-disubstituted N-acetyl-N-phenylbenzylamines, dissolved in DMSO-d6, were measured employing the temperature dependence of the ¹H-NMR spectrum lineshape between 340 and 400 K. The results ar...

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Autores principales: WEISS-LOPEZ,BORIS E, JULLIAN,CAROLINA, SAITZ,CLAUDIO, PESSOA-MAHANA,HERNAN, VALDERRAMA,JAIME, ARAYA-MATURANA,RAMIRO
Lenguaje:English
Publicado: Sociedad Chilena de Química 2001
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442001000300005
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Sumario:Activation parameters for the rotation around the methylene-nitrogen single bond found in a series of four 2,2´-disubstituted N-acetyl-N-phenylbenzylamines, dissolved in DMSO-d6, were measured employing the temperature dependence of the ¹H-NMR spectrum lineshape between 340 and 400 K. The results are : (I) 2 ­ [N-acetyl -N- (2-acetamidophenyl) aminomethyl]phenylacetate deltaG<FONT FACE=Symbol>¹</FONT > or = 79.9±2.0 kJ/mol (370K), deltaH<FONT FACE=Symbol>¹</FONT > or = 96.2±6.0 kJ/mol and deltaS<FONT FACE=Symbol>¹</FONT > or = +45±20 J/Kmol; (II) 2 - [N ­ acetyl ­ N - (2-acetyloxybenzyl)amino]benzylacetate deltaG<FONT FACE=Symbol>¹</FONT > or = 82.0±2.0 kJ/mol (370K), deltaH<FONT FACE=Symbol>¹</FONT > or = 79.1±6.0 kcal/mol and deltaS<FONT FACE=Symbol>¹</FONT > or = -8±20 J/Kmol; (III) 2 - [N ­ Acetyl ­ N ­ (2-nitrobenzyl)amino]benzylacetate deltaG<FONT FACE=Symbol>¹</FONT > or = 80.8±2.0 kJ/mol (380K), deltaH<FONT FACE=Symbol>¹</FONT > or = 60.7±6.0 kcal/mol and deltaS<FONT FACE=Symbol>¹</FONT > or = -53±20 J/Kmol; (IV) 2-[N­Acetyl­N-(2-acetyloxybenzyl)amino]phenylacetate deltaG<FONT FACE=Symbol>¹</FONT > or = 77.0±2.0 kJ/mol (370K), deltaH<FONT FACE=Symbol>¹</FONT > or = 65.3±6.0 kJ/mol and deltaS<FONT FACE=Symbol>¹</FONT > or = -32±20 J/Kmol. Substitution at positions 2 and 2´ with bulky groups appears to be essential to freeze the gauche structure at room temperature and consequently, the main contribution to the barrier arises from the steric hindrance between these two groups. Structure I shows an anomalous behavior, possibly due to the formation of a hydrogen bond between the NH at position 2´ and the solvent. This interaction increases deltaHpi and freezes the rotation around the aryl-nitrogen bond, increasing deltaS<FONT FACE=Symbol>¹</FONT>