Tetraazamacrocyclic Complexes of Tin(II): Synthesis Spectroscopy and Biological screening
Sixteen to eighteen membered tetraamide macrocyclic ligands N4L¹ and N4L² have been prepared by the condensation of 1,2-diaminoethane or 1,3-diaminopropane with phthalic acid in the presence of condensing reagents dicyclohexylcarbodiimide and 4- dimethylaminopyridine. On reduction, these macrocyclic...
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| Autores principales: | , , |
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| Lenguaje: | English |
| Publicado: |
Sociedad Chilena de Química
2002
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| Materias: | |
| Acceso en línea: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442002000300002 |
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| Sumario: | Sixteen to eighteen membered tetraamide macrocyclic ligands N4L¹ and N4L² have been prepared by the condensation of 1,2-diaminoethane or 1,3-diaminopropane with phthalic acid in the presence of condensing reagents dicyclohexylcarbodiimide and 4- dimethylaminopyridine. On reduction, these macrocyclic ligands give new tetraazamacrocycles N4L³ and N4L4 which form complexes with tin(II) chloride. The macrocyclic ligands and their complexes have been characterized by elemental analysis, molecular weight determinations, conductance, IR and ¹H NMR spectral studies. The spectral data suggested hexacoordinated state for tin in these complexes. Conductivity data suggested that they behave as non-electrolytes. An octahedral geometry for these complexes has been proposed as the binding sites are the nitrogen atoms of the macrocycles. The formulation of the complexes of the type [Sn(N4Ln)Cl2] has been established on the basis of chemical composition. The ligands and their complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential |
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