Tetraazamacrocyclic Complexes of Tin(II): Synthesis Spectroscopy and Biological screening
Sixteen to eighteen membered tetraamide macrocyclic ligands N4L¹ and N4L² have been prepared by the condensation of 1,2-diaminoethane or 1,3-diaminopropane with phthalic acid in the presence of condensing reagents dicyclohexylcarbodiimide and 4- dimethylaminopyridine. On reduction, these macrocyclic...
Saved in:
| Main Authors: | , , |
|---|---|
| Language: | English |
| Published: |
Sociedad Chilena de Química
2002
|
| Subjects: | |
| Online Access: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442002000300002 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Sixteen to eighteen membered tetraamide macrocyclic ligands N4L¹ and N4L² have been prepared by the condensation of 1,2-diaminoethane or 1,3-diaminopropane with phthalic acid in the presence of condensing reagents dicyclohexylcarbodiimide and 4- dimethylaminopyridine. On reduction, these macrocyclic ligands give new tetraazamacrocycles N4L³ and N4L4 which form complexes with tin(II) chloride. The macrocyclic ligands and their complexes have been characterized by elemental analysis, molecular weight determinations, conductance, IR and ¹H NMR spectral studies. The spectral data suggested hexacoordinated state for tin in these complexes. Conductivity data suggested that they behave as non-electrolytes. An octahedral geometry for these complexes has been proposed as the binding sites are the nitrogen atoms of the macrocycles. The formulation of the complexes of the type [Sn(N4Ln)Cl2] has been established on the basis of chemical composition. The ligands and their complexes have been screened in vitro against a number of pathogenic fungi and bacteria to assess their growth inhibiting potential |
|---|