ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTS

Apomorphine acts as contractile muscular agent through an extra cellular calcium mechanism dependent. This activity is accompanied with autoxidación process producing o-quinone derivates. o-Quinone is also obtained by apomorphine oxidation in acid medium; in basic conditions a hydroxi-p-quinone is f...

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Autores principales:	Olea-Azar,C., Alarcón,J, Opazo,L., Abarca,B., Ballesteros,R., Bielsa,P.
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2002
Materias:	ESR apomorphine quinones Cyclic Voltammetry Spin Trapping
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442002000400009
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spelling	oai:scielo:S0366-164420020004000092009-12-18ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTSOlea-Azar,C.Alarcón,JOpazo,L.Abarca,B.Ballesteros,R.Bielsa,P. ESR apomorphine quinones Cyclic Voltammetry Spin Trapping Apomorphine acts as contractile muscular agent through an extra cellular calcium mechanism dependent. This activity is accompanied with autoxidación process producing o-quinone derivates. o-Quinone is also obtained by apomorphine oxidation in acid medium; in basic conditions a hydroxi-p-quinone is formed. In order to characterize the apomorphine derivates species generated via metabolism or chemical mechanism, specially free radical forms, electrochemical and Electronic Spin Resonance studies were done to o and p-quinones metabolites in presence or absence of Calcium ions. The electrochemical study of these compounds using cyclic voltametric indicated that the reduction mechanism consists of two steps, the formation of semiquinonic radical and finally the production of hydroquinone derivatives. Calcium ions not modified the reduction couples of these compounds. Electronic Spin Resonance spectroscopy was used to characterize the radical species generated. The hyperfine constants obtained by theoretical calculations were in agreement with the experimental values. Beside, the radical species generated through apomorphine oxidation were detected using Spin Trapping technique. Finally, these results would be indicating the possible existence of radicals species in the reduction mechanism of o and p-quinone as well oxidation process of apomorphine which could be involved in the contractile activity mechanism.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaBoletín de la Sociedad Chilena de Química v.47 n.4 20022002-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442002000400009en10.4067/S0366-16442002000400009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	ESR apomorphine quinones Cyclic Voltammetry Spin Trapping
spellingShingle	ESR apomorphine quinones Cyclic Voltammetry Spin Trapping Olea-Azar,C. Alarcón,J Opazo,L. Abarca,B. Ballesteros,R. Bielsa,P. ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTS
description	Apomorphine acts as contractile muscular agent through an extra cellular calcium mechanism dependent. This activity is accompanied with autoxidación process producing o-quinone derivates. o-Quinone is also obtained by apomorphine oxidation in acid medium; in basic conditions a hydroxi-p-quinone is formed. In order to characterize the apomorphine derivates species generated via metabolism or chemical mechanism, specially free radical forms, electrochemical and Electronic Spin Resonance studies were done to o and p-quinones metabolites in presence or absence of Calcium ions. The electrochemical study of these compounds using cyclic voltametric indicated that the reduction mechanism consists of two steps, the formation of semiquinonic radical and finally the production of hydroquinone derivatives. Calcium ions not modified the reduction couples of these compounds. Electronic Spin Resonance spectroscopy was used to characterize the radical species generated. The hyperfine constants obtained by theoretical calculations were in agreement with the experimental values. Beside, the radical species generated through apomorphine oxidation were detected using Spin Trapping technique. Finally, these results would be indicating the possible existence of radicals species in the reduction mechanism of o and p-quinone as well oxidation process of apomorphine which could be involved in the contractile activity mechanism.
author	Olea-Azar,C. Alarcón,J Opazo,L. Abarca,B. Ballesteros,R. Bielsa,P.
author_facet	Olea-Azar,C. Alarcón,J Opazo,L. Abarca,B. Ballesteros,R. Bielsa,P.
author_sort	Olea-Azar,C.
title	ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTS
title_short	ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTS
title_full	ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTS
title_fullStr	ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTS
title_full_unstemmed	ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTS
title_sort	electron spin resonance and electrochemical studies of oxidation products derivates of apomorphine in aprotic solvents
publisher	Sociedad Chilena de Química
publishDate	2002
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0366-16442002000400009
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ELECTRON SPIN RESONANCE AND ELECTROCHEMICAL STUDIES OF OXIDATION PRODUCTS DERIVATES OF APOMORPHINE IN APROTIC SOLVENTS

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