Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model

Background: Preload dynamic tests, pulse pressure variation (PPV) and stroke volume variation (SVV) have emerged as powerful tools to predict response to fluid administration. The influence of factors other than preload in dynamic preload test is currently poorly understood in pediatrics. The aim of...

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Autores principales:	Erranz,Benjamín, Díaz,Franco, Donoso,Alejandro, Salomón,Tatiana, Carvajal,Cristóbal, Torres,María Fernanda, Cruces,Pablo
Lenguaje:	English
Publicado:	Sociedad Chilena de Pediatría 2015
Materias:	Hemodynamics Preload Acute lung injury Mechanical ventilation Pediatric
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062015000600005
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spelling	oai:scielo:S0370-410620150006000052015-12-29Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury modelErranz,BenjamínDíaz,FrancoDonoso,AlejandroSalomón,TatianaCarvajal,CristóbalTorres,María FernandaCruces,Pablo Hemodynamics Preload Acute lung injury Mechanical ventilation Pediatric Background: Preload dynamic tests, pulse pressure variation (PPV) and stroke volume variation (SVV) have emerged as powerful tools to predict response to fluid administration. The influence of factors other than preload in dynamic preload test is currently poorly understood in pediatrics. The aim of our study was to assess the effect of tidal volume (V T) on PPV and SVV in the context of normal and reduced lung compliance in a piglet model. Material and method: Twenty large-white piglets (5.2 ± 0.4 kg) were anesthetized, paralyzed and monitored with pulse contour analysis. PPV and SVV were recorded during mechanical ventilation with a V T of 6 and 12 mL/kg (low and high V T, respectively), both before and after tracheal instillation of polysorbate 20. Results: Before acute lung injury (ALI) induction, modifications of V T did not significantly change PPV and SVV readings. After ALI, PPV and SVV were significantly greater during ventilation with a high V T compared to a low V T (PPV increased from 8.9 ± 1.2 to 12.4 ± 1.1%, and SVV from 8.5 ± 1.0 to 12.7 ± 1.2%, both P < 0.01). Conclusions: This study found that a high V T and reduced lung compliance due to ALI increase preload dynamic tests, with a greater influence of the latter. In subjects with ALI, lung compliance should be considered when interpreting the preload dynamic tests.info:eu-repo/semantics/openAccessSociedad Chilena de PediatríaRevista chilena de pediatría v.86 n.6 20152015-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062015000600005en10.1016/j.rchipe.2015.06.023
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Hemodynamics Preload Acute lung injury Mechanical ventilation Pediatric
spellingShingle	Hemodynamics Preload Acute lung injury Mechanical ventilation Pediatric Erranz,Benjamín Díaz,Franco Donoso,Alejandro Salomón,Tatiana Carvajal,Cristóbal Torres,María Fernanda Cruces,Pablo Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model
description	Background: Preload dynamic tests, pulse pressure variation (PPV) and stroke volume variation (SVV) have emerged as powerful tools to predict response to fluid administration. The influence of factors other than preload in dynamic preload test is currently poorly understood in pediatrics. The aim of our study was to assess the effect of tidal volume (V T) on PPV and SVV in the context of normal and reduced lung compliance in a piglet model. Material and method: Twenty large-white piglets (5.2 ± 0.4 kg) were anesthetized, paralyzed and monitored with pulse contour analysis. PPV and SVV were recorded during mechanical ventilation with a V T of 6 and 12 mL/kg (low and high V T, respectively), both before and after tracheal instillation of polysorbate 20. Results: Before acute lung injury (ALI) induction, modifications of V T did not significantly change PPV and SVV readings. After ALI, PPV and SVV were significantly greater during ventilation with a high V T compared to a low V T (PPV increased from 8.9 ± 1.2 to 12.4 ± 1.1%, and SVV from 8.5 ± 1.0 to 12.7 ± 1.2%, both P < 0.01). Conclusions: This study found that a high V T and reduced lung compliance due to ALI increase preload dynamic tests, with a greater influence of the latter. In subjects with ALI, lung compliance should be considered when interpreting the preload dynamic tests.
author	Erranz,Benjamín Díaz,Franco Donoso,Alejandro Salomón,Tatiana Carvajal,Cristóbal Torres,María Fernanda Cruces,Pablo
author_facet	Erranz,Benjamín Díaz,Franco Donoso,Alejandro Salomón,Tatiana Carvajal,Cristóbal Torres,María Fernanda Cruces,Pablo
author_sort	Erranz,Benjamín
title	Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model
title_short	Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model
title_full	Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model
title_fullStr	Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model
title_full_unstemmed	Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model
title_sort	decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model
publisher	Sociedad Chilena de Pediatría
publishDate	2015
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0370-41062015000600005
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Decreased lung compliance increases preload dynamic tests in a pediatric acute lung injury model

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