Genome dynamics, genetic complexity and macroevolution

Genome data analysis indicates that the major evolutionary transitions have been driven by substantial increases in genomic complexity. These increases, accounting for novelty in evolution, have proceeded mainly by gene duplication. This idea, advanced by <A HREF="#OHNO">Ohno (1968)&...

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Autor principal:	GALLARDO,MILTON
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2003
Materias:	gene duplication genome genetics evolution macroevolution evolutionary theory
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2003000400013
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spelling	oai:scielo:S0716-078X20030004000132004-03-24Genome dynamics, genetic complexity and macroevolutionGALLARDO,MILTON gene duplication genome genetics evolution macroevolution evolutionary theory Genome data analysis indicates that the major evolutionary transitions have been driven by substantial increases in genomic complexity. These increases, accounting for novelty in evolution, have proceeded mainly by gene duplication. This idea, advanced by <A HREF="#OHNO">Ohno (1968)</A>, remains current in the study of several organisms whose genomes have been sequenced. Maize, yeast, and humans contain more paralogons than would be expected to occur by chance, and this supports the contention that gene families were not formed de novo, but by large-scale DNA duplications. Lineage hybridization emerges as an efficient and widespread mechanism to create evolutionary novelty by recruiting redundant genes to new roles. Lateral gene transfer indicates a chimeric composition of prokaryote genomes. This peculiar manner of inheritance blurs the edges of phylogenetic lineages and suggests that the anastomosing and dichotomization of branches play key roles in determining the shape of the tree of life. Adaptive mutations have also enlarged the genetic framework of evolutionary thought by incorporating a new mechanism of gene formation. Moreover, developmental biology has provided solid grounds for understanding organisms as consisting of onto- and epigenetically organized modules. Rapid and drastic changes brought about by the study of developmental genes have discredited the notions that adaptation is achieved exclusively by stepwise allele replacement within populations, and that macroevolutionary change is extrapolated microevolution. Apparently, a broadening, if not a remodeling of the genetic framework in which we understand phylogeny and the evolution of morphological complexity, is emerging through the study of comparative genomicsinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileRevista chilena de historia natural v.76 n.4 20032003-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2003000400013en10.4067/S0716-078X2003000400013
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	gene duplication genome genetics evolution macroevolution evolutionary theory
spellingShingle	gene duplication genome genetics evolution macroevolution evolutionary theory GALLARDO,MILTON Genome dynamics, genetic complexity and macroevolution
description	Genome data analysis indicates that the major evolutionary transitions have been driven by substantial increases in genomic complexity. These increases, accounting for novelty in evolution, have proceeded mainly by gene duplication. This idea, advanced by <A HREF="#OHNO">Ohno (1968)</A>, remains current in the study of several organisms whose genomes have been sequenced. Maize, yeast, and humans contain more paralogons than would be expected to occur by chance, and this supports the contention that gene families were not formed de novo, but by large-scale DNA duplications. Lineage hybridization emerges as an efficient and widespread mechanism to create evolutionary novelty by recruiting redundant genes to new roles. Lateral gene transfer indicates a chimeric composition of prokaryote genomes. This peculiar manner of inheritance blurs the edges of phylogenetic lineages and suggests that the anastomosing and dichotomization of branches play key roles in determining the shape of the tree of life. Adaptive mutations have also enlarged the genetic framework of evolutionary thought by incorporating a new mechanism of gene formation. Moreover, developmental biology has provided solid grounds for understanding organisms as consisting of onto- and epigenetically organized modules. Rapid and drastic changes brought about by the study of developmental genes have discredited the notions that adaptation is achieved exclusively by stepwise allele replacement within populations, and that macroevolutionary change is extrapolated microevolution. Apparently, a broadening, if not a remodeling of the genetic framework in which we understand phylogeny and the evolution of morphological complexity, is emerging through the study of comparative genomics
author	GALLARDO,MILTON
author_facet	GALLARDO,MILTON
author_sort	GALLARDO,MILTON
title	Genome dynamics, genetic complexity and macroevolution
title_short	Genome dynamics, genetic complexity and macroevolution
title_full	Genome dynamics, genetic complexity and macroevolution
title_fullStr	Genome dynamics, genetic complexity and macroevolution
title_full_unstemmed	Genome dynamics, genetic complexity and macroevolution
title_sort	genome dynamics, genetic complexity and macroevolution
publisher	Sociedad de Biología de Chile
publishDate	2003
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-078X2003000400013
work_keys_str_mv	AT gallardomilton genomedynamicsgeneticcomplexityandmacroevolution
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Genome dynamics, genetic complexity and macroevolution

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