Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistencia

The aminoglycoside-aminocyclitol antibiotics constitute one of the antibacterial agent families with greater activity upon aerobic Gram-negative bacilli. These compounds are formed by the combination of one amino-cyclic alcohol (aminocyclitol) and aminosaccharides (aminoglycosides) linked by glycosi...

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Autores principales:	Mella M.,Sergio, Sepúlveda A.,Marcela, González R.,Gerardo, BelloT.,Helia, Domínguez Y.,Mariana, Zemelman Z.,Raúl, Ramírez G.,César
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Chilena de Infectología 2004
Materias:	Aminoglucósidos Resistencia Integrón
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182004000400007
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id	oai:scielo:S0716-10182004000400007
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spelling	oai:scielo:S0716-101820040004000072005-04-14Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistenciaMella M.,SergioSepúlveda A.,MarcelaGonzález R.,GerardoBelloT.,HeliaDomínguez Y.,MarianaZemelman Z.,RaúlRamírez G.,César Aminoglucósidos Resistencia Integrón The aminoglycoside-aminocyclitol antibiotics constitute one of the antibacterial agent families with greater activity upon aerobic Gram-negative bacilli. These compounds are formed by the combination of one amino-cyclic alcohol (aminocyclitol) and aminosaccharides (aminoglycosides) linked by glycosidic bonds. The strong bactericidal activity exhibited for these compounds is not only explained by their ability to inhibit the protein synthesis, but also by pleiotropic effect altering the permeability of cytoplasmatic membrane. The penetration of these antibiotics to the bacterial cells is mediated by three well defined phases, being the two latest dependant of the proton-motive force. This fact explains that this kind of compounds have no antibacterial activity upon anaerobic bacteria. Bacterial resistance to aminoglycosides is mainly due to aminoglycoside-modifying enzymes (AME), which are commonly encoded by extrachromosomal genetic elements as are plasmids and transposons. Nevertheless, new mechanisms of resistance and genetic elements participating in the resistance to these compounds have been identified. Thus, recently the methylation of the 16S rRNA binding the aminoglycosides has been described. On the other hand, the gene cassettes acquire an increasing importance, because they can host a varied of families of antibiotic resistance genes, including the aminoglycoside-aminocyclitols. These gene cassettes are associated to integrons, which are able to integrate and express these antibiotic resistance determinants.info:eu-repo/semantics/openAccessSociedad Chilena de InfectologíaRevista chilena de infectología v.21 n.4 20042004-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182004000400007es10.4067/S0716-10182004000400007
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aminoglucósidos Resistencia Integrón
spellingShingle	Aminoglucósidos Resistencia Integrón Mella M.,Sergio Sepúlveda A.,Marcela González R.,Gerardo BelloT.,Helia Domínguez Y.,Mariana Zemelman Z.,Raúl Ramírez G.,César Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistencia
description	The aminoglycoside-aminocyclitol antibiotics constitute one of the antibacterial agent families with greater activity upon aerobic Gram-negative bacilli. These compounds are formed by the combination of one amino-cyclic alcohol (aminocyclitol) and aminosaccharides (aminoglycosides) linked by glycosidic bonds. The strong bactericidal activity exhibited for these compounds is not only explained by their ability to inhibit the protein synthesis, but also by pleiotropic effect altering the permeability of cytoplasmatic membrane. The penetration of these antibiotics to the bacterial cells is mediated by three well defined phases, being the two latest dependant of the proton-motive force. This fact explains that this kind of compounds have no antibacterial activity upon anaerobic bacteria. Bacterial resistance to aminoglycosides is mainly due to aminoglycoside-modifying enzymes (AME), which are commonly encoded by extrachromosomal genetic elements as are plasmids and transposons. Nevertheless, new mechanisms of resistance and genetic elements participating in the resistance to these compounds have been identified. Thus, recently the methylation of the 16S rRNA binding the aminoglycosides has been described. On the other hand, the gene cassettes acquire an increasing importance, because they can host a varied of families of antibiotic resistance genes, including the aminoglycoside-aminocyclitols. These gene cassettes are associated to integrons, which are able to integrate and express these antibiotic resistance determinants.
author	Mella M.,Sergio Sepúlveda A.,Marcela González R.,Gerardo BelloT.,Helia Domínguez Y.,Mariana Zemelman Z.,Raúl Ramírez G.,César
author_facet	Mella M.,Sergio Sepúlveda A.,Marcela González R.,Gerardo BelloT.,Helia Domínguez Y.,Mariana Zemelman Z.,Raúl Ramírez G.,César
author_sort	Mella M.,Sergio
title	Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistencia
title_short	Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistencia
title_full	Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistencia
title_fullStr	Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistencia
title_full_unstemmed	Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistencia
title_sort	aminoglucósidos-aminociclitoles: características estructurales y nuevos aspectos sobre su resistencia
publisher	Sociedad Chilena de Infectología
publishDate	2004
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-10182004000400007
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Aminoglucósidos-aminociclitoles: Características estructurales y nuevos aspectos sobre su resistencia

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