Lipid peroxidation and antioxidants in hyperlipidemia and hypertension

Lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. To clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of LDL, the antioxidant status and the lipi...

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Autores principales:	MORIEL,PATRICIA, PLAVNIK,FRIDA L, ZANELLA,MARIA T, BERTOLAMI,MARCELO C, ABDALLA,DULCINEIA SP
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2000
Materias:	Lipoprotein oxidation lipid peroxides isoprostanes antioxidants atherosclerosis oxidative stress
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200010
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spelling	oai:scielo:S0716-976020000002000102010-02-11Lipid peroxidation and antioxidants in hyperlipidemia and hypertensionMORIEL,PATRICIAPLAVNIK,FRIDA LZANELLA,MARIA TBERTOLAMI,MARCELO CABDALLA,DULCINEIA SP Lipoprotein oxidation lipid peroxides isoprostanes antioxidants atherosclerosis oxidative stress Lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. To clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of LDL, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (HC), hypertensive (H), hypercholesterolemic/hypertensive (HH) and normolipidemic/normotensive subjects (N). Plasma ascorbate and lipid-soluble antioxidants were lower, while LDL oxidizability, CE-OOH and TL-OOH were higher in H, HC, and HH groups than in the N group. No difference was observed among groups for PL-OOH and isoprostanes. In summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the LDL susceptibility to oxidation were higher; 2) total cholesterol, LDL-cholesterol, apoB and CE-OOH were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of LDL to oxidation; and 4) CE-OOH and TL-OOH were positively correlated with total cholesterol and LDL-cholesterol.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.33 n.2 20002000-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200010en10.4067/S0716-97602000000200010
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Lipoprotein oxidation lipid peroxides isoprostanes antioxidants atherosclerosis oxidative stress
spellingShingle	Lipoprotein oxidation lipid peroxides isoprostanes antioxidants atherosclerosis oxidative stress MORIEL,PATRICIA PLAVNIK,FRIDA L ZANELLA,MARIA T BERTOLAMI,MARCELO C ABDALLA,DULCINEIA SP Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
description	Lipid peroxidation and lipid-derived oxidized products have been implicated in the pathogenesis of a variety of human diseases. To clarify the role of oxidative stress in essential hypertension and hypercholesterolemia the in vitro oxidative susceptibility of LDL, the antioxidant status and the lipid peroxide content of blood plasma were examined in hypercholesterolemic (HC), hypertensive (H), hypercholesterolemic/hypertensive (HH) and normolipidemic/normotensive subjects (N). Plasma ascorbate and lipid-soluble antioxidants were lower, while LDL oxidizability, CE-OOH and TL-OOH were higher in H, HC, and HH groups than in the N group. No difference was observed among groups for PL-OOH and isoprostanes. In summary, the results show that: 1) lipid- and water-soluble antioxidants are lower in hypercholesterolemic and hypertensive patients as compared to normal subjects, whereas the lipid peroxide content and the LDL susceptibility to oxidation were higher; 2) total cholesterol, LDL-cholesterol, apoB and CE-OOH were negatively correlated with the content of a-tocopherol; 3) there was a positive correlation between the content of lipid-soluble antioxidants and the resistance of LDL to oxidation; and 4) CE-OOH and TL-OOH were positively correlated with total cholesterol and LDL-cholesterol.
author	MORIEL,PATRICIA PLAVNIK,FRIDA L ZANELLA,MARIA T BERTOLAMI,MARCELO C ABDALLA,DULCINEIA SP
author_facet	MORIEL,PATRICIA PLAVNIK,FRIDA L ZANELLA,MARIA T BERTOLAMI,MARCELO C ABDALLA,DULCINEIA SP
author_sort	MORIEL,PATRICIA
title	Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
title_short	Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
title_full	Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
title_fullStr	Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
title_full_unstemmed	Lipid peroxidation and antioxidants in hyperlipidemia and hypertension
title_sort	lipid peroxidation and antioxidants in hyperlipidemia and hypertension
publisher	Sociedad de Biología de Chile
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200010
work_keys_str_mv	AT morielpatricia lipidperoxidationandantioxidantsinhyperlipidemiaandhypertension AT plavnikfridal lipidperoxidationandantioxidantsinhyperlipidemiaandhypertension AT zanellamariat lipidperoxidationandantioxidantsinhyperlipidemiaandhypertension AT bertolamimarceloc lipidperoxidationandantioxidantsinhyperlipidemiaandhypertension AT abdalladulcineiasp lipidperoxidationandantioxidantsinhyperlipidemiaandhypertension
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Lipid peroxidation and antioxidants in hyperlipidemia and hypertension

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