Amyloid-ß-peptide reduces copper(II) to copper(I) independent of its aggregation state

Amyloid-ß-peptide reduces copper(II) to copper(I) independent of its aggregation state

Alzheimer’s disease (AD) is characterized by the deposition of amyloid b-peptide (Aß) and neuronal degeneration in brain regions involved in learning and memory. One of the leading etiologic hypotheses regarding AD is the involvement of free radical-mediated oxidative stress in neuronal degeneration...

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Autores principales: OPAZO,CARLOS, RUIZ,FRANCISCA H, INESTROSA,NIBALDO C
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2000
Materias:
Aß peptide
amyloid fibrils
copper reduction
oxidative damage
Alzheimer’s Disease
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200012
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