Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis

Atherosclerosis is one of the most common diseases and the principal cause of death in western civilization. The pathogenesis of this disease can be explained on the basis of the oxidative-modification hypothesis, which proposes that low-density lipoprotein (LDL) oxidation represents a key early e...

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Autores principales:	RUBBO,HOMERO, BATTHYANY,CARLOS, RADI,RAFAEL
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2000
Materias:	antioxidants free radicals lipid oxidation low density lipoprotein oxidation nitric oxide peroxynitrite
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200017
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spelling	oai:scielo:S0716-976020000002000172010-02-11Nitric Oxide: Oxygen Radical Interactions in AtherosclerosisRUBBO,HOMEROBATTHYANY,CARLOSRADI,RAFAEL antioxidants free radicals lipid oxidation low density lipoprotein oxidation nitric oxide peroxynitrite Atherosclerosis is one of the most common diseases and the principal cause of death in western civilization. The pathogenesis of this disease can be explained on the basis of the oxidative-modification hypothesis, which proposes that low-density lipoprotein (LDL) oxidation represents a key early event. Nitric oxide (.NO) regulates critical lipid membrane and lipoprotein oxidation events by a) contributing to the formation of more potent secondary oxidants from superoxide (i.e.: peroxynitrite), and b) its antioxidant properties through termination reactions with lipid radicals to possibly less reactive secondary nitrogen-containing products (LONO, LOONO). Relative rates of production and steady state concentrations of superoxide and .NO and cellular sites of production will profoundly influence the expression of differential oxidant injury-enhancing and protective effects of .NO. Full understanding of the physiological roles of .NO, coupled with detailed insight into .NO regulation of oxygen radical-dependent reactions, will yield a more rational basis for intervention strategies directed toward oxidant-dependent atherogenic processesinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.33 n.2 20002000-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200017en10.4067/S0716-97602000000200017
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	antioxidants free radicals lipid oxidation low density lipoprotein oxidation nitric oxide peroxynitrite
spellingShingle	antioxidants free radicals lipid oxidation low density lipoprotein oxidation nitric oxide peroxynitrite RUBBO,HOMERO BATTHYANY,CARLOS RADI,RAFAEL Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis
description	Atherosclerosis is one of the most common diseases and the principal cause of death in western civilization. The pathogenesis of this disease can be explained on the basis of the oxidative-modification hypothesis, which proposes that low-density lipoprotein (LDL) oxidation represents a key early event. Nitric oxide (.NO) regulates critical lipid membrane and lipoprotein oxidation events by a) contributing to the formation of more potent secondary oxidants from superoxide (i.e.: peroxynitrite), and b) its antioxidant properties through termination reactions with lipid radicals to possibly less reactive secondary nitrogen-containing products (LONO, LOONO). Relative rates of production and steady state concentrations of superoxide and .NO and cellular sites of production will profoundly influence the expression of differential oxidant injury-enhancing and protective effects of .NO. Full understanding of the physiological roles of .NO, coupled with detailed insight into .NO regulation of oxygen radical-dependent reactions, will yield a more rational basis for intervention strategies directed toward oxidant-dependent atherogenic processes
author	RUBBO,HOMERO BATTHYANY,CARLOS RADI,RAFAEL
author_facet	RUBBO,HOMERO BATTHYANY,CARLOS RADI,RAFAEL
author_sort	RUBBO,HOMERO
title	Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis
title_short	Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis
title_full	Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis
title_fullStr	Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis
title_full_unstemmed	Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis
title_sort	nitric oxide: oxygen radical interactions in atherosclerosis
publisher	Sociedad de Biología de Chile
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200017
work_keys_str_mv	AT rubbohomero nitricoxideoxygenradicalinteractionsinatherosclerosis AT batthyanycarlos nitricoxideoxygenradicalinteractionsinatherosclerosis AT radirafael nitricoxideoxygenradicalinteractionsinatherosclerosis
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Nitric Oxide: Oxygen Radical Interactions in Atherosclerosis

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