Misconceptions and false expectations in neutral evolution

Neutral evolution results from random recurrent mutation and genetic drift. A small part of random evolution, that which is related to protein or DNA polymorphisms, is the subject of the Neutral Theory of Evolution. One of the foundations of this theory is the demonstration that the mutation rate (m...

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Autor principal:	VALENZUELA,CARLOS Y.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2000
Materias:	neutral evolution neutral theory misconceptions bases fixation elimination
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000300004
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spelling	oai:scielo:S0716-976020000003000042014-05-06Misconceptions and false expectations in neutral evolutionVALENZUELA,CARLOS Y. neutral evolution neutral theory misconceptions bases fixation elimination Neutral evolution results from random recurrent mutation and genetic drift. A small part of random evolution, that which is related to protein or DNA polymorphisms, is the subject of the Neutral Theory of Evolution. One of the foundations of this theory is the demonstration that the mutation rate (m) is equal to the substitution rate. Since both rates are independent of population size, they are independent of drift, which is dependent upon population size. Neutralists have erroneously equated the substitution rate with the fixation rate, despite the fact that they are antithetical conceptions. The neutralists then applied the random walk stochastic model to justify alleles or bases that were fixated or eliminated. In this model, once the allele or base frequencies reach the monomorphic states (values of 1.0 or 0.0), the absorbing barriers, they can no longer return to the polymorphic state. This operates in a pure mathematical model. If recurrent mutation occurs (as in biotic real systems) fixation and elimination are impossible. A population of bacteria in which m=10-8 base mutation (or substitution)/site/generation and the reproduction rate is 1000 cell cycle/year should replace all its genome bases in approximately 100,000 years. The expected situation for all sites is polymorphism for the four bases rather than monomorphism at 1.0 or 0.0 frequencies. If fixation and elimination of a base for more than 500,000 years are impossible, then most of the neutral theory is untenable. A new complete neutral model, which allows for recurrent substitutions, is proposed here based on recurrent mutation or substitution and drift alone. The model fits a binomial or Poisson distribution and not a geometric one, as does neutral theory.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.33 n.3-4 20002000-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000300004en10.4067/S0716-97602000000300004
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	neutral evolution neutral theory misconceptions bases fixation elimination
spellingShingle	neutral evolution neutral theory misconceptions bases fixation elimination VALENZUELA,CARLOS Y. Misconceptions and false expectations in neutral evolution
description	Neutral evolution results from random recurrent mutation and genetic drift. A small part of random evolution, that which is related to protein or DNA polymorphisms, is the subject of the Neutral Theory of Evolution. One of the foundations of this theory is the demonstration that the mutation rate (m) is equal to the substitution rate. Since both rates are independent of population size, they are independent of drift, which is dependent upon population size. Neutralists have erroneously equated the substitution rate with the fixation rate, despite the fact that they are antithetical conceptions. The neutralists then applied the random walk stochastic model to justify alleles or bases that were fixated or eliminated. In this model, once the allele or base frequencies reach the monomorphic states (values of 1.0 or 0.0), the absorbing barriers, they can no longer return to the polymorphic state. This operates in a pure mathematical model. If recurrent mutation occurs (as in biotic real systems) fixation and elimination are impossible. A population of bacteria in which m=10-8 base mutation (or substitution)/site/generation and the reproduction rate is 1000 cell cycle/year should replace all its genome bases in approximately 100,000 years. The expected situation for all sites is polymorphism for the four bases rather than monomorphism at 1.0 or 0.0 frequencies. If fixation and elimination of a base for more than 500,000 years are impossible, then most of the neutral theory is untenable. A new complete neutral model, which allows for recurrent substitutions, is proposed here based on recurrent mutation or substitution and drift alone. The model fits a binomial or Poisson distribution and not a geometric one, as does neutral theory.
author	VALENZUELA,CARLOS Y.
author_facet	VALENZUELA,CARLOS Y.
author_sort	VALENZUELA,CARLOS Y.
title	Misconceptions and false expectations in neutral evolution
title_short	Misconceptions and false expectations in neutral evolution
title_full	Misconceptions and false expectations in neutral evolution
title_fullStr	Misconceptions and false expectations in neutral evolution
title_full_unstemmed	Misconceptions and false expectations in neutral evolution
title_sort	misconceptions and false expectations in neutral evolution
publisher	Sociedad de Biología de Chile
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000300004
work_keys_str_mv	AT valenzuelacarlosy misconceptionsandfalseexpectationsinneutralevolution
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Misconceptions and false expectations in neutral evolution

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