Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives

Red blood cell carbonic anhydrase (CA) activity has not been studied in high altitude natives. Because CA is an intraerythocytic enzyme and high altitude natives are polycythemic, it is important to know if the activity of CA per red cell volume is different from that of their sea level counterparts...

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Autores principales:	GAMBOA,JORGE, CACEDA,RICARDO, GAMBOA,ALFREDO, MONGE-C,CARLOS
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2000
Materias:	Carbonic anhydrase hypoxia polycythemia
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000300006
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spelling	oai:scielo:S0716-976020000003000062014-05-06Carbonic anhydrase activity in the red blood cells of sea level and high altitude nativesGAMBOA,JORGECACEDA,RICARDOGAMBOA,ALFREDOMONGE-C,CARLOS Carbonic anhydrase hypoxia polycythemia Red blood cell carbonic anhydrase (CA) activity has not been studied in high altitude natives. Because CA is an intraerythocytic enzyme and high altitude natives are polycythemic, it is important to know if the activity of CA per red cell volume is different from that of their sea level counterparts. Blood was collected from healthy subjects living in Lima (150m) and from twelve subjects from Cerro de Pasco (4330m), and hematocrit and carbonic anhydrase activity were measured. As expected, the high altitude natives had significantly higher hematocrits than the sea level controls (p=0.0002). No difference in the CA activity per milliliter of red cells was found between the two populations. There was no correlation between the hematocrit and CA activity.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.33 n.3-4 20002000-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000300006en10.4067/S0716-97602000000300006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Carbonic anhydrase hypoxia polycythemia
spellingShingle	Carbonic anhydrase hypoxia polycythemia GAMBOA,JORGE CACEDA,RICARDO GAMBOA,ALFREDO MONGE-C,CARLOS Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives
description	Red blood cell carbonic anhydrase (CA) activity has not been studied in high altitude natives. Because CA is an intraerythocytic enzyme and high altitude natives are polycythemic, it is important to know if the activity of CA per red cell volume is different from that of their sea level counterparts. Blood was collected from healthy subjects living in Lima (150m) and from twelve subjects from Cerro de Pasco (4330m), and hematocrit and carbonic anhydrase activity were measured. As expected, the high altitude natives had significantly higher hematocrits than the sea level controls (p=0.0002). No difference in the CA activity per milliliter of red cells was found between the two populations. There was no correlation between the hematocrit and CA activity.
author	GAMBOA,JORGE CACEDA,RICARDO GAMBOA,ALFREDO MONGE-C,CARLOS
author_facet	GAMBOA,JORGE CACEDA,RICARDO GAMBOA,ALFREDO MONGE-C,CARLOS
author_sort	GAMBOA,JORGE
title	Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives
title_short	Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives
title_full	Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives
title_fullStr	Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives
title_full_unstemmed	Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives
title_sort	carbonic anhydrase activity in the red blood cells of sea level and high altitude natives
publisher	Sociedad de Biología de Chile
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000300006
work_keys_str_mv	AT gamboajorge carbonicanhydraseactivityintheredbloodcellsofsealevelandhighaltitudenatives AT cacedaricardo carbonicanhydraseactivityintheredbloodcellsofsealevelandhighaltitudenatives AT gamboaalfredo carbonicanhydraseactivityintheredbloodcellsofsealevelandhighaltitudenatives AT mongeccarlos carbonicanhydraseactivityintheredbloodcellsofsealevelandhighaltitudenatives
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Carbonic anhydrase activity in the red blood cells of sea level and high altitude natives

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