Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets

The biological characterization of bloodstream forms of eleven Trypanosoma cruzi cloned stocks, corresponding to two genetically similar clonets (<A HREF="#19">19</A> and <A HREF="#20">20</A>) and one distant clonet (39), according to multilocus enzyme ele...

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Autores principales:	WALLACE,ANNE, ORTÍZ,SILVIA, SÁNCHEZ,GITTITH, VILLAGRA,REBECA, MUGA,MABEL, SOLARI,ALDO
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2001
Materias:	Trypanosoma cruzi clonets parasitemia mortality bloodstream forms multilocus enzyme electrophoresis
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200011
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spelling	oai:scielo:S0716-976020010002000112002-01-02Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonetsWALLACE,ANNEORTÍZ,SILVIASÁNCHEZ,GITTITHVILLAGRA,REBECAMUGA,MABELSOLARI,ALDO Trypanosoma cruzi clonets parasitemia mortality bloodstream forms multilocus enzyme electrophoresis The biological characterization of bloodstream forms of eleven Trypanosoma cruzi cloned stocks, corresponding to two genetically similar clonets (<A HREF="#19">19</A> and <A HREF="#20">20</A>) and one distant clonet (39), according to multilocus enzyme electrophoresis analysis, showed dissimilar parasitemia in an experimental isogenic mouse model. While clonet 39 stocks gave low parasitemias, clonets 19 or 20 stocks gave high parasitemias, independently of the inocula (10² and 10(4) bloodstream forms) used. High parasitemia did not always associate with greater mortality. Statistical studies on mortality using a low inocula showed significantly higher mortality with clonet 39 stocks when compared to clonets 19 or 20 stocks. Finally, in order to confirm the identity of each stock studied, typing by molecular karyotype was performed before inoculating mice.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.34 n.2 20012001-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200011en10.4067/S0716-97602001000200011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Trypanosoma cruzi clonets parasitemia mortality bloodstream forms multilocus enzyme electrophoresis
spellingShingle	Trypanosoma cruzi clonets parasitemia mortality bloodstream forms multilocus enzyme electrophoresis WALLACE,ANNE ORTÍZ,SILVIA SÁNCHEZ,GITTITH VILLAGRA,REBECA MUGA,MABEL SOLARI,ALDO Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets
description	The biological characterization of bloodstream forms of eleven Trypanosoma cruzi cloned stocks, corresponding to two genetically similar clonets (<A HREF="#19">19</A> and <A HREF="#20">20</A>) and one distant clonet (39), according to multilocus enzyme electrophoresis analysis, showed dissimilar parasitemia in an experimental isogenic mouse model. While clonet 39 stocks gave low parasitemias, clonets 19 or 20 stocks gave high parasitemias, independently of the inocula (10² and 10(4) bloodstream forms) used. High parasitemia did not always associate with greater mortality. Statistical studies on mortality using a low inocula showed significantly higher mortality with clonet 39 stocks when compared to clonets 19 or 20 stocks. Finally, in order to confirm the identity of each stock studied, typing by molecular karyotype was performed before inoculating mice.
author	WALLACE,ANNE ORTÍZ,SILVIA SÁNCHEZ,GITTITH VILLAGRA,REBECA MUGA,MABEL SOLARI,ALDO
author_facet	WALLACE,ANNE ORTÍZ,SILVIA SÁNCHEZ,GITTITH VILLAGRA,REBECA MUGA,MABEL SOLARI,ALDO
author_sort	WALLACE,ANNE
title	Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets
title_short	Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets
title_full	Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets
title_fullStr	Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets
title_full_unstemmed	Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets
title_sort	studies on parasitemia courses and mortality in mice infected with genetically distant trypanosoma cruzi clonets
publisher	Sociedad de Biología de Chile
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200011
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Studies on parasitemia courses and mortality in mice infected with genetically distant Trypanosoma cruzi clonets

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