The autonomous axon: a model based on local synthesis of proteins

In the current understanding of axons, axoplasmic synthesis of proteins is negated, and it is asserted that proteins are transported from perikarya to axons. This 'transport model' in which axons are fully dependent of perikarya is seriously flawed. The 'autonomous axon' proposed...

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Autor principal:	ALVAREZ,JAIME
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2001
Materias:	plasticity regeneration Schwann cell slow transport sprouting trophism Wld s
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200014
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spelling	oai:scielo:S0716-976020010002000142002-01-02The autonomous axon: a model based on local synthesis of proteinsALVAREZ,JAIME plasticity regeneration Schwann cell slow transport sprouting trophism Wld s In the current understanding of axons, axoplasmic synthesis of proteins is negated, and it is asserted that proteins are transported from perikarya to axons. This 'transport model' in which axons are fully dependent of perikarya is seriously flawed. The 'autonomous axon' proposed here negates in turn transport of proteins, and asserts (i) local synthesis of axoplasmic proteins, corner stone of this model, (ii) existence of internal programs in axon and terminals, (iii) external control of programs resulting in local regulation of phenotype of axons and terminals, hence they are autonomous from perikarya; (iv) participation of perikarya through the fast transport in setting up the axonal programs but not in their immediate regulation. The word merotrophism (meros meaning part) denotes post-transcriptional regulation of phenotype of restricted regions of a cell. We surmise that merotrophism is at the base of many plastic phenomena.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.34 n.2 20012001-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200014en10.4067/S0716-97602001000200014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	plasticity regeneration Schwann cell slow transport sprouting trophism Wld s
spellingShingle	plasticity regeneration Schwann cell slow transport sprouting trophism Wld s ALVAREZ,JAIME The autonomous axon: a model based on local synthesis of proteins
description	In the current understanding of axons, axoplasmic synthesis of proteins is negated, and it is asserted that proteins are transported from perikarya to axons. This 'transport model' in which axons are fully dependent of perikarya is seriously flawed. The 'autonomous axon' proposed here negates in turn transport of proteins, and asserts (i) local synthesis of axoplasmic proteins, corner stone of this model, (ii) existence of internal programs in axon and terminals, (iii) external control of programs resulting in local regulation of phenotype of axons and terminals, hence they are autonomous from perikarya; (iv) participation of perikarya through the fast transport in setting up the axonal programs but not in their immediate regulation. The word merotrophism (meros meaning part) denotes post-transcriptional regulation of phenotype of restricted regions of a cell. We surmise that merotrophism is at the base of many plastic phenomena.
author	ALVAREZ,JAIME
author_facet	ALVAREZ,JAIME
author_sort	ALVAREZ,JAIME
title	The autonomous axon: a model based on local synthesis of proteins
title_short	The autonomous axon: a model based on local synthesis of proteins
title_full	The autonomous axon: a model based on local synthesis of proteins
title_fullStr	The autonomous axon: a model based on local synthesis of proteins
title_full_unstemmed	The autonomous axon: a model based on local synthesis of proteins
title_sort	autonomous axon: a model based on local synthesis of proteins
publisher	Sociedad de Biología de Chile
publishDate	2001
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602001000200014
work_keys_str_mv	AT alvarezjaime theautonomousaxonamodelbasedonlocalsynthesisofproteins AT alvarezjaime autonomousaxonamodelbasedonlocalsynthesisofproteins
_version_	1718441329537581056

The autonomous axon: a model based on local synthesis of proteins

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